Publikationen

Selected Publications

April 10, 2025

2025

Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors.
Patel A, Göbel K, Ille S, Hinz F, Schoebe N, Bogumil H, Meyer J, Brehm M, Kardo H, Schrimpf D, Lomakin A, Ritter M, Göller P, Kerbs P, Pfeifer L, Hamelmann S, Blume C, Ippen FM, Berghaus N, Euskirchen P, Schweizer L, Hultschig C, Van Roy N, Van Dorpe J, Van der Meulen J, Loontiens S, Dedeurwaerdere F, Leske H, Halldórsson S, Fox G, Deacon S, Cahyani I, Holmes N, Wibowo S, Munro R, Martin D, Sharif A, Housley M, Goldspring R, Brandner S, Roy S, Hench J, Frank S, Unterberg A, Goidts V, Jäger N, Paine S, Smith S, Herold-Mende C, Wick W, Pfister SM, Vik-Mo EO, von Deimling A, Krieg S, Jones DT, Loose M, Schlesner M, Sill M, Sahm F.
Nat Med. 2025 Mar 25. doi: 10.1038/s41591-025-03562-5. Online ahead of print.

Updated EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection-Update 1.
van den Bent MJ, Franceschi E, Touat M, French PJ, Idbaih A, Lombardi G, Rudà R, Schweizer L, Capper D, Sanson M, Wesseling P, Weller M, Eoli M, Anghileri E, Bielle F, Euskirchen P, Geurts M, Wen PY, Preusser M.
Neuro Oncol. 2025 Feb 10;27(2):331-337. doi: 10.1093/neuonc/noae213.

 

2024

EANO guideline on molecular testing of meningiomas for targeted therapy selection.
Sahm F, Bertero L, Brandner S, Capper D, Goldbrunner R, Jenkinson MD, Kalamarides M, Lamszus K, Albert NL, Mair MJ, Berghoff AS, Mawrin C, Wirsching HG, Maas SL, Raleigh DR, Reifenberger G, Schweizer L, Suwala AK, Tabatabai G, Tabouret E, Short S, Wen PY, Weller M, Le Rhun E, Wesseling P, van den Bent M, Preusser M.
Neuro Oncol. 2024 Nov 22:noae253. doi: 10.1093/neuonc/noae253. Online ahead of print.

Targeted whole-viral genome sequencing from formalin-fixed paraffin-embedded neuropathology specimens.
Gorißen C, Albers A, Ruf V, Chteinberg E, Siebert R, Schweizer L, Kaufmann L, Kühn JE, Tappe D, Kuhlmann T, Thomas C.
Acta Neuropathol. 2024 Oct 9;148(1):51. doi: 10.1007/s00401-024-02812-z.

Integrated analyses reveal two molecularly and clinically distinct subtypes of H3 K27M-mutant diffuse midline gliomas with prognostic significance.
Stegat L, Eckhardt A, Gocke A, Neyazi S, Pohl L, Schmid S, Dottermusch M, Frank S, Pinnschmidt H, Herms J, Glatzel M, Snuderl M, Schweizer L, Thomas C, Neumann J, Dorostkar MM, Schüller U, Wefers AK.
Acta Neuropathol. 2024 Sep 10;148(1):40. doi: 10.1007/s00401-024-02800-3.

Morphology-based molecular classification of spinal cord ependymomas using deep neural networks.
Schumann Y, Dottermusch M, Schweizer L, Krech M, Lempertz T, Schüller U, Neumann P, Neumann JE.
Brain Pathol. 2024 Sep;34(5):e13239. doi: 10.1111/bpa.13239. Epub 2024 Jan 11.

Identification of a putative molecular subtype of adult-type diffuse astrocytoma with recurrent MAPK pathway alterations.
Sievers P, Bielle F, Göbel K, Schrimpf D, Nichelli L, Mathon B, Appay R, Boldt HB, Dohmen H, Selignow C, Acker T, Vicha A, Martinetto H, Schweizer L, Schüller U, Brandner S, Wesseling P, Schmid S, Capper D, Abdullaev Z, Aldape K, Korshunov A, Krieg SM, Wick W, Pfister SM, von Deimling A, Reuss DE, Jones DTW, Sahm F.
Acta Neuropathol. 2024 Jul 18;148(1):7. doi: 10.1007/s00401-024-02766-2.

Sliding Window Optimal Transport for Open World Artifact Detection in Histopathology.
Fuchs M, Konstantin M, Schrade N, Schweizer L, Tolkach Y, Mukhopadhyay A.
IEEE J Biomed Health Inform. 2024 Jul;28(7):4094-4104. doi: 10.1109/JBHI.2024.3383590. Epub 2024 Jul 2.

Correction: Clinical implications of DNA methylation-based integrated classification of histologically defined grade 2 meningiomas.
Ehret F, Perez E, Teichmann D, Meier S, Geiler C, Zeus C, Franke H, Roohani S, Wasilewski D, Onken J, Vajkoczy P, Schweizer L, Kaul D, Capper D.
Acta Neuropathol Commun. 2024 Jun 15;12(1):96. doi: 10.1186/s40478-024-01801-3.

Clinical implications of DNA methylation-based integrated classification of histologically defined grade 2 meningiomas.
Ehret F, Perez E, Teichmann D, Meier S, Geiler C, Zeus C, Franke H, Roohani S, Wasilewski D, Onken J, Vajkoczy P, Schweizer L, Kaul D, Capper D.
Acta Neuropathol Commun. 2024 May 8;12(1):74. doi: 10.1186/s40478-024-01739-6.

Nanopore sequencing from formalin-fixed paraffin-embedded specimens for copy-number profiling and methylation-based CNS tumor classification.
Afflerbach AK, Albers A, Appelt A, Schweizer L, Paulus W, Bockmayr M, Schüller U, Thomas C.
Acta Neuropathol. 2024 Apr 20;147(1):74. doi: 10.1007/s00401-024-02731-z.

Validation of a methylation-based signature for subventricular zone involvement in glioblastoma.
Ehret F, Zühlke O, Schweizer L, Kahn J, Csapo-Schmidt C, Roohani S, Zips D, Capper D, Adeberg S, Abdollahi A, Knoll M, Kaul D.
J Neurooncol. 2024 Mar;167(1):89-97. doi: 10.1007/s11060-024-04570-0. Epub 2024 Feb 20

Prevalence of TERT Promoter Mutations in Orbital Solitary Fibrous Tumors.
Koca DS, Kolpakov V, Ihlow J, von Laffert M, Erb-Eigner K, Herbst H, Kriese K, Schweizer L, Bertelmann E.
Curr Issues Mol Biol. 2024 Feb 10;46(2):1467-1484. doi: 10.3390/cimb46020095.

Molecular characteristics and improved survival prediction in a cohort of 2023 ependymomas.
Pohl LC, Leitheiser M, Obrecht D, Schweizer L, Wefers AK, Eckhardt A, Raffeld M, Sturm D, Pajtler KW, Rutkowski S, Fukuoka K, Ichimura K, Bockmayr M, Schüller U.
Acta Neuropathol. 2024 Jan 24;147(1):24. doi: 10.1007/s00401-023-02674-x.

Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation.
Neyazi S, Yamazawa E, Hack K, Tanaka S, Nagae G, Kresbach C, Umeda T, Eckhardt A, Tatsuno K, Pohl L, Hana T, Bockmayr M, Kim P, Dorostkar MM, Takami T, Obrecht D, Takai K, Suwala AK, Komori T, Godbole S, Wefers AK, Otani R, Neumann JE, Higuchi F, Schweizer L, Nakanishi Y, Monoranu CM, Takami H, Engertsberger L, Yamada K, Ruf V, Nomura M, Mohme T, Mukasa A, Herms J, Takayanagi S, Mynarek M, Matsuura R, Lamszus K, Ishii K, Kluwe L, Imai H, von Deimling A, Koike T, Benesch M, Kushihara Y, Snuderl M, Nambu S, Frank S, Omura T, Hagel C, Kugasawa K, Mautner VF, Ichimura K, Rutkowski S, Aburatani H, Saito N, Schüller U.
Acta Neuropathol. 2024 Jan 24;147(1):22. doi: 10.1007/s00401-023-02668-9.