Klinik für Psychiatrie, Psychosomatik und Psychotherapie

Forschung

Geriatric Psychiatry

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Research Focus

  • Geriatric Depression
  • Mild cognitive impairment (MCI)
  • Clinical studies (MCI and Alzheimer´s Disease)

Methods

  • Diffusion Tensor Imaging (DTI)
  • Fuctional Neuroimaging (fMRI)
  • Neuropsychology
  • Clinical research

Group members

Alumni: Lea Hohl (PhD student), Hamed Gharoony (PhD student)

Collaborations

  • Prof. Dr. Johannes Pantel, Geriatric Medicine, Institute of General Practice, Goethe-University, Frankfurt/Main
  • PD Dr. Dipl.-Psych. Julia Haberstroh, Interdisziplinäre Alternswissenschaft, Goethe-University, Frankfurt/Main
  • Prof. Dr. Isabella Heuser, PD Dr. Oliver Peters, Klinik für Psychiatrie und Psychotherapie, Charitè, Berlin (SIMaMCI)

Selected Publications

  • Matura, S., Prvulovic, D., Hartmann, D., Scheibe, M., Sepanski, B., Butz, M., Oertel-Knochel, V., Knöchel, C., Karakaya, T., Fusser, F., Hattingen, E., & Pantel, J. (2016). Age-Related Effects of the Apolipoprotein E Gene on Brain Function. J Alzheimers Dis, 52(1), 317-331.
  • Matura S, Prvulovic D, Butz M, Hartmann D, Sepanski B, Linnemann K, Oertel-Knöchel V, Karakaya T, Fußer F, Pantel J, van de Ven V. Recognition memory is associated with altered resting-state functional connectivity in people at genetic risk for Alzheimer's disease. Eur J Neurosci. 2014; 40(7):3128-35. Epub 2014 Jul 3.
  • Matura S, Prvulovic D, Jurcoane A, Hartmann D, Miller J, Scheibe M, O'Dwyer L, Oertel-Knöchel V, Knöchel C, Reinke B, Karakaya T, Fußer F, Pantel J. Differential effects of the ApoE4 genotype on brain structure and function. Neuroimage. 2014; 89:81-91. Epub 2013 Dec 1.
  • Tesky V, Hermann N, Kümmel A, Schall A, Karakaya T, Pantel J. Förderung kognitiv-stimulierender Freizeitaktivitäten bei türkischen Migranten. Präv Gesundheitsförd. 2014; 9(1):60-5. Epub 2013 Nov 27..
  • Alves G*, Karakaya T*, Fußer F*, Kordulla M, O´Dwyer L, Christl J, Magerkurth J, Oertel-Knöchel V, Knöchel C, Prvulovic D, Jurcoane A, Laks J, Engelhardt E, Hampel H, Pantel J. Association of microstructural white matter abnormalities with cognitive dysfunction in geriatric patients with major depression. Psychiatry Research: Neuroimaging, 2012, 203(2-3):194-200. (*equal contribution)
  • Alves GS, O'Dwyer L, Jurcoane A, Oertel-Knöchel V, Knöchel C, Prvulovic D, Sudo F, Alves CE, Valente L, Moreira D, Fuβer F, Karakaya T, Pantel J, Engelhardt E, Laks J. Different patterns of white matter degeneration using multiple diffusion indices and volumetric data in mild cognitive impairment and Alzheimer patients. PLoS One. 2012;7(12):e52859. doi: 10.1371/journal.pone.0052859.

Conference abstracts

  • Fußer F, Matura S, Prvulovic P, Pantel J, Karakaya T. Impact of CR1 on white matter microstructure in cognitively healthy elders – a diffusion tensor imaging (DTI) study. WPA XVII World Congress of Psychiatry, Berlin 2017.
  • Karakaya T, Prvulovic D, Mohadjer N, Fußer F, Miller J, Oertel-Knöchel V, Reif A, Pantel J, Matura S. Dietary fat composition correlates with verbal memory and frontal grey and white matter volume in healthy individuals: an MRI study. AAIC (Alzheimer´s Association International Conference), London 2017
  • Fußer F, Prvulovic P, Matura S, Pantel J, Karakaya T. Impact of ApoE4 on white matter microstructure in mild cognitive impairment. A diffusion tensor imaging (DTI) study. DGPPN Congress, Berlin 2016.

 Reviews

  • Fußer F, Karakaya T, Pantel J. Depression im Alter. transferplus, Fokus:Altenpflege, 7; 2013.
  • Karakaya T, Fußer F, Schröder J, Pantel J. Pharmacological treatment of Mild Cognitive Impairment as a prodromal syndrome of Alzheimer´s disease. Current Neuropharmacology, 2013, 11(1), 102-108.
  • Karakaya T, Prvulovic D, Fußer F, Hampel H. Biomarker des Morbus Alzheimer: Schon Praxisrelevant? Neuro aktuell, 6,2012
  • Fußer F, Karakaya T, Prvulovic D, Hampel H. Improving the accuracy of dementia diagnosis with functional imaging. Dementia Europe 2012, 4:4-6.
  • Karakaya T, Fußer F, Prvulovic D, Hampel H. Treatment Options for Tauopathies. Current Treatment Options in Neurology, 2012, Apr;14(2):126-36.

 Book chapters

  • Fußer F, Karakaya K, Pantel J. Late-life depression. In: Carvalho AF, Manning JS, McIntyre RS (Hg.) Mental Disorders in Primary Care - A Guide to their Evaluation and Treatment, Oxford University Press, Oxford 2017.
  • Karakaya T, Fußer F. Kognition, Intellektueller Abbau, Leichte kognitive Beeinträchtigung, Demenzen. In: Pantel J, Schröder J, Sieber C & Kruse A (Hrsg.). Praxishandbuch der Altersmedizin – Geriatrie, Gerontopsychiatrie, Gerontologie. Kohlhammer, Stuttgart 2014
  • Karakaya T, Pantel J. Psychopharmakaintervention bei primär affektiven Störungen. In Wahl H-W, Tesch-Römer C, Ziegelmann J (Hrsg.) Angewandte Gerontologie: Interventionen für ein gutes Altern in 100 Schlüsselbegriffen. Kohlhammer, Stuttgart 2012
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