Publikationen

Selected Publications

April 3, 2025

Strassheimer F, Elleringmann P, Ludmirski G, Roller B, Macas J, Alekseeva T, Cakmak P, Aliraj B, Krenzlin H, Demes MC, Mildenberger IC, Tonn T, Weber KJ, Reiss Y, Plate KH, Weigert A, Wels WS, Steinbach JP, Burger MC. CAR-NK cell therapy combined with checkpoint inhibition induces an NKT cell response in glioblastoma. Br J Cancer. 2025 Mar 18. doi: 10.1038/s41416-025-02977-8.

Roesler J, Spitzer D, Jia X, Aasen SN, Sommer K, Roller B, Olshausen N, Hebach NR, Albinger N, Ullrich E, Zhu L, Wang F, Macas J, Forster MT, Steinbach JP, Sevenich L, Devraj K, Thorsen F, Karreman MA, Plate KH*, Reiss Y*, Harter PN*. Disturbance in cerebral blood microcirculation and hypoxic-ischemic microenvironment are associated with the development of brain metastasis. Neuro Oncol. 2024 Nov 4;26(11):2084-2099. 
doi: 10.1093/neuonc/noae094.

Pinar C, Lun JH, Singh A, Macas J, Schupp J, Köhler M, Starzetz T, Burger MC, Steidl E, Hasse LM, Hattingen E, Plate KH*, Reiss Y*, Imkeller K*. Glioma-associated tertiary Lymphoid structures are sites of lymphocyte clonal expansion and plasma cell formation. bioRxiv 2024.07.04.602038. doi: doi.org/10.1101/2024.07.04.602038.

Mughal S*, Reiss Y*, Felsberg J, Meyer L, Macas J, Schlue S, Starzetz T, Köhrer K, Fehm T, Müller V, Lamszus K, Schadendorf D, Helfrich I, Wikman H, Berghoff A, Brors B, Plate KH, Reifenberger G. Identification and characterization of tertiary lymphoid structures in brain metastases. bioRxiv 2024.09.30.614674. doi: doi.org/10.1101/2024.09.30.614674.

Salamero-Boix A, Schulz M, Anthes J, Mayer J, Möckl A, Tsoukala I, Menger D, Mosa MH, Hetzer J, Macas J, Hehlgans S, Schuck J, Roller B, Reiss Y, Hochart G, Bonnel D, Medyouf H, Barcenas Rodriguez M, Broggini T, Czabanka M, Plate KH, Heikenwälder M, Rödel F, Harter PN, Imkeller K, Sevenich L. Modulation of the ATP-adenosine signaling axis combined with radiotherapy facilitates anti-cancer immunity in brain metastasis. bioRxiv 2024.09.30.615883. doi: doi.org/10.1101/2024.09.30.615883.

Picard D, Felsberg J, Langini M, Stachura P, Qin N, Macas J, Reiss Y, Bartl J, Selt F, Sigaud R, Meyer FD, Stefanski A, Stühler K, Roque L, Roque R, Pandyra AA, Brozou T, Knobbe-Thomsen C, Plate KH, Roesch A, Milde T, Reifenberger G, Leprivier G, Faria CC, Remke M. Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma. Acta Neuropathol. 2023 Oct;146(4):551-564. doi: 10.1007/s00401-023-02626-5.

Burger MC, Forster MT, Romanski A, Straßheimer F, Macas J, Zeiner PS, Steidl E, Herkt S, Weber KJ, Schupp J, Lun JH, Strecker MI, Wlotzka K, Cakmak P, Opitz C, George R, Mildenberger IC, Nowakowska P, Zhang C, Röder J, Müller E, Ihrig K, Langen KJ, Rieger MA, Herrmann E, Bonig H, Harter PN, Reiss Y, Hattingen E, Rödel F, Plate KH, Tonn T, Senft C, Steinbach JP, Wels WS. Intracranial injection of natural killer cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastoma. Neuro Oncol. 2023 Nov 2;25(11):2058-2071. 
doi: 10.1093/neuonc/noad087

Spitzer D, Khel MI, Pütz T, Zinke J, Jia X, Sommer K, Filipski K, Thorsen F, Freiman TM, Günther S, Plate KH, Harter PN, Liebner S, Reiss Y, Di Tacchio M, Guérit S, Devraj K. A flow cytometry-based protocol for syngenic isolation of neurovascular unit cells from mouse and human tissues. Nat Protoc. 2023 May;18(5):1510-1542. 
doi: 10.1038/s41596-023-00805-y.

Reiss Y, Bauer S, David B, Devraj K, Fidan E, Hattingen E, Liebner S, Melzer N, Meuth SG, Rosenow F, Rüber T, Willems LM, Plate KH. The neurovasculature as a target in temporal lobe epilepsy. Brain Pathol. 2023 Mar;33(2):e13147. doi: 10.1111/bpa.13147.

Spitzer D, Puetz T, Armbrust M, Dunst M, Macas J, Croll F, Plate KH, Reiss Y, Liebner S, Harter PN, Guérit S, Devraj K. Anti-osteopontin therapy leads to improved edema and infarct size in a murine model of ischemic stroke. Sci Rep. 2022 Dec 3;12(1):20925. doi: 10.1038/s41598-022-25245-8. PMID: 36463381; PMCID: PMC9719559.

Spitzer D, Guérit S, Puetz T, Khel MI, Armbrust M, Dunst M, Macas J, Zinke J, Devraj G, Jia X, Croll F, Sommer K, Filipski K, Freiman TM, Looso M, Günther S, Di Tacchio M, Plate KH, Reiss Y, Liebner S, Harter PN, Devraj K. Profiling the neurovascular unit unveils detrimental effects of osteopontin on the bloodbrain barrier in acute ischemic stroke. Acta Neuropathol. 2022 Aug;144(2):305-337. doi: 10.1007/s00401-022-02452-1.