AG Frank
Analysis of gene expression patterns during normal and diabetes-impaired cutaneous wound healing
Stefan Frank (group leader), Itamar Goren, Patrick Schröter
Diabetes mellitus has seen an extensive global increase, which had been predicted more than a decade ago. Diabetic skin ulcerations represent a severe complication of the disease, and more important, a still unmet medical problem associated with significant mortality. Moreover, diabetic ulcers have a poor prognosis and the 3-year survival rate after amputations are only between 50 and 59%. Unfortunately, underlying molecular processes which lead to an impaired regeneration of skin tissue are only poorly understood. We utilize mouse models of excisional wound repair to gain a closer insight in molecular movements of tissue repair. Besides physiologically healthy mice, we also use diabetic and obese mice as animal models to unravel molecular and cellular mechanisms that might form the basis of or at least contribute to diabetes-disturbed wound conditions. Our work is focused on MACE (Massive Analysis of cDNA Ends) analysis, that allows us a comprehensive insight into transcriptional events during wound healing. This method thus provides the basis for a subsequent analysis of differentially regulated genes in normal and diabetes-impaired wound healing.
Meine Vorlesungen „Allgemeine Pharmakologie“ sind verfügbar unter folgendem Link auf Youtube:
https://www.youtube.com/channel/UCFLlboeliKwkpEUJQF45d3A/videos