Institut für Allgemeine Pharmakologie und Toxikologie

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Inhalte auf dieser Seite: Publikationen 2024

Publikationen 2024

Alcober-Boquet L, Kraus N, Huber LS, Vutukuri R, Fuhrmann DC, Stross C, Schaefer L, Scholich K, Zeuzem S, Piiper A, Schulz MH, Trebicka J, Welsch C, and Ortiz C. BI-3231, an enzymatic inhibitor of HSD17B13, reduces lipotoxic effects induced by palmitic acid in murine and human hepatocytes. Am J Physiol Cell Physiol., 326(3): C880-C892, 2024 

Raith J, Bachmann M, Gonther S, Stülb H, Aghdassi AA, Pham CTN, and Mühl H. Targeting cathepsin C ameliorates murine acetaminophen-induced liver injury. Theranostics, 14(8): 3029-3042, 2024

Shah HS, Zaib S, Usman F, Sarfraz M, Faiz R, Rehman SA, Khan AA, Alanazi AM, Khan R, Nasrullah U, Nazir I. Synthesis, characterization, pharmacological and computational evaluation of hyaluronic acid modified chebulinic acid encapsulated chitosan nanocomposite for cancer therapy. Int J Biol Macromol., 263(Pt 1): 130160, 2024

Bender C, Müller P, Tondello C, Horn J, Holdener M, Lasch S, Bayer M, Pfeilschifter JM, Tacke F, Ludwig A, Hansmann ML, Döring C, Hintermann E, and Christen U. Gene-expression profiling of laser-dissected islets and studies in deficient mice reveal chemokines as differential driving force of type 1 diabetes. J Autoimmun., 143: 103161, 2024

Hintermann E, Tondello C, Fuchs S, Bayer M, Pfeilschifter JM, Taubert R, Mollenhauer M, Elferink RPJO, Manns MP, and Christen U. Blockade of neutrophil extracellular trap components ameliorates cholestatic liver disease in Mdr2 (Abcb4) knockout mice. J Autoimmun., 146: 103229, 2024

Schmithals C, Kakoschky B, Denk D, von Harten M, Klug JH, Hintermann E, Dropmann A, Hamza E, Jacomin AC, Marquardt JU, Zeuzem S, Schirmacher P, Herrmann E, Christen U, Vogl TJ, Waidmann O, Dooley S, Finkelmeier F, and Piiper A. Tumour-specific activation of a tumour-blood transport improves the diagnostic accuracy of blood tumour markers in mice. EBioMedicine, 105: 105178, 2024  

Pfeilschifter J and Gulbins E. Tribute to Andrea Huwiler (1966-2023). Pflugers Arch. 2024 Apr 9. doi: 10.1007/s00424-024-02958-5. Epub ahead of print. PMID: 38592461.

 

 

Publikationen 2023

Merline R and Schaefer L. A novel regulator of selective autophagy: TNIP1/ABIN-1 modulates mitophagy. Autophagy Reports KAUO, doi: 10.1080/27694127.2023.2165269, 2023

Nold SP, Sych K, Imre G, Fuhrmann DC, Pfeilschifter J, Vutukuri R, Schnutgen F, Wittig I, Meisterknecht J, Frank S, and Goren I. Reciprocal abrogation of PKM isoforms: Contradictory outcomes and differing impact of splicing signal on CRISPR/Cas9 mediates gene editing in keratinocytes. FEBS J., 290(9): 2338-2365, 2023 

Merline R, Roedig H, Zeng-Brouwers J, Poluzzi C, Tascher G, Michaelis J, Lopez-Mosqueda J, Huber LS, Diehl V, Dikic I, Kögel D, Münch C, Wygrecka M, and Schaefer L. A20 binding and inhibitor of NFkB (ABIN-1) - a novel modulator of mitochondrial autophagy. Am J Physiol-Cell Physiol., 324(2): C339-C352, 2023

Wygrecka M, Alexopoulos I, Potaczek DP, and Schaefer L. Diverse Functions of Apolipoprotein A-I in Lung Fibrosis. Am J Physiol. Cell Physiol., 324(2): C438-C446, 2023  

Sych K, Nold SP, Pfeilschifter J, Vutukuri R, Meisterknecht J, Wittig I, Frank S and  Goren I. Expression of PKM2 in wound keratin ocytes is coupled to angiogenesis during skin repair in vivo and in HaCaT keratinocytes in vitro. J Mol.Med.(Berl), 101(1-2): 151-169, 2023

Zeng-Brouwers J, Huber LS, Merline R, Trebicka J, Wygrecka M, and Schaefer L. Evaluation of the In Vitro and In Vivo Effects of Biglycan in Innate Immunity. Methods Mol Biol., 2619: 109-124, 2023

Delpire E, Hawke T, Karthikeyan M, Kong W, Nyström A, Uchida S, and Schaefer L: American Journal of Physiology-Cell Physiology in 2022: at a glance. Am J Physiol Cell Physiol, 324(2): C553-C557, 2023.

Ballhausen A, Ben Hamza A, Welters C, Dietze K, Bullinger L, Rahn HP, Hartmann S, Hansmann ML, and Hansmann L. Immune phenotypes and checkpoint molecule expression of clonally expanded lymph node-infiltrating T cells in classical Hodgkin lymphoma. Cancer Immunol Immunother., 72(2): 515-521, 2023

Schaefer L and Pierre SV. Cell and Molecular Physiology Section of the American Physiological Society in connection with American Journal of Physiology-Cell Physiology. Am J Physiol Cell Physiol., 325(1): C362-C363, 2023

Nasrullah U, Stanke K, Recknagel V, Bozkurt S, Wurzel P, Gauer S, Imre G, Münch C, Pfeilschifter J, and Eberhardt W. The E3 Ligase TRIM25 Impairs Apoptotic Cell Death in Colon Carcinoma Cells via Destabilization of Caspase-7 mRNA: A Possible Role of hnRNPH1. Cells, 12(1): 201, 2023

Li Z, Xia H, Sharp TE 3rd, LaPenna KB, Katsouda A, Elrod JW, Pfeilschifter J, Beck KF, Xu S, Xian M, Goodchild TT, Papapetropoulos A, and Lefer DJ. Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure. Circ Res., 132(2): 154-166, 2023

Röhrig AM, Jakobi K, Dietz J, Thomas D, Herrmann E, Welsch C, Sarrazin C, Pfeilschifter J, Zeuzem S, and Grammatikos G. The role of serum sphingolipids as potential biomarkers of non-response to direct acting antiviral therapy in chronic hepatitis C virus infection. J Viral Hepat., 30(2): 138-147, 2023

Imeri F, Tanturovska, BS, Manaila R, Pavenstädt H, Pfeilschifter J, and Huwiler A. Loss of S1P Lyase expression in human podocytes causes a reduction in nephrin expression that involves PKC activation. Int J Mol Sci., 24, 3267, 2023

Scharf S, Ackermann J, Bender L, Wurzel P, Schäfer H, Hansmann ML, and Koch, I. Holistic View on the Structure of Immune Response: Petri Net Model. Biomedicines, 11(2), 452, 2023

Hansmann ML, Klauschen F, Samek W, Müller KR, Donnadieu E, Scharf S, Hartmann Sy, Koch I, Ackermann J, Pantanowitz L, Schäfer H, and Wurzel P. Imaging bridges pathology and radiology, Journal of Pathology Informatics, Volume 14,100298, ISSN 2153-3539, 2023

Huwiler A, Beck KF, and Pfeilschifter J. Cross-regulation of the cellular redox system, oxygen, and sphingolipid signalling. Metabolites, 13(3): 426, 2023

Shainer R, Kram V, Kilts TM, Li L, Doyle AD, Shainer I, Martin D, Simon CG Jr, Zeng-Brouwers J, Schaefer L, and Young MF. Genomics and Computational Biology Core. Biglycan regulates bone development and regeneration. Front Physiol.,14: 1119368, 2023

Miethe S, Potaczek DP, Bazan-Socha S, Bachl M, Schaefer L, Wygrecka M, and Garn H. The emerging role of extracellular vesicles as communicators between adipose tissue and pathologic lungs with a special focus on asthma. Am J Physiol Cell Physiol., 324(5): C1119-C1125, 2023

Schierwagen R, Gu W, Brieger A, Brüne B, Ciesek S, Đikić I, Dimmeler S, Geisslinger G, Greten FR, Herrmann E, Hildt E, Kempf VAJ, Klein S, Koch I, Mühl H, Müller V, Peiffer KH, Kestner RI, Piiper A, Rohde G, Scholich K, Schulz MH, Storf H, Toptan T, Vasa-Nicotera M, Vehreschild MJGT, Weigert A, Wild PJ, Zeuzem S, Engelmann C; ACLF-I investigators; Schaefer L, Welsch C, and Trebicka J. Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure. Am J Physiol Cell Physiol., 325(1): C129-C140, 2023

Erdogan BR, Michel MB, Matthes J, Castañeda TR, Christen U, Arioglu-Inan E, Michel MC, and Pautz A. A comparison of urinary bladder weight in male and female mice across five models of diabetes and obesity. Front Pharmacol., 14: 1118730, 2023

Schemel CM, Wurzel P, Scharf S, Schäfer H, Hartmann S, Koch I and Hansmann ML. Three-dimensional human germinal centers of different sizes in patients diagnosed with lymphadenitis show comparative constant relative volumes of B cells, T cells, follicular dendritic cells, and macrophages. Acta Histochemica, 125(7), 152075, 2023

Merk-Ahmad K, Bein J, Scharf S, Schäfer H, Bexte T, Ullrich E, Loth AG, Flinner N, Senff T, Schneider O, Hansmann ML, Piel M, Häupl B, Oellerich T, Donnadieu E, and Hartmann S. The RHOA Mutation G17V Does Not Lead to Increased Migration of Human Malignant T Cells but Is Associated with Matrix Remodelling. Cancers (Basel), 15(12): 3226, 2023

Anzaghe M, Niles MA, Korotkova E, Dominguez M, Kronhart S, Bechmann I, Bachmann M, Mühl, H, Kochs G, and Waibler Z. Interleukin-36γ is causative for liver damage upon infection with Rift Valley fever virus in type I interferon receptor-deficient mice. Front Immunol, 14: 1194733. 2023

Nyström A, Schaefer L. An American Journal of Physiology-Cell Physiology for the present and the future. Am J Physiol. Cell Physiol., 325(5): C1155-C11572023, 2023

Xie Ch, Schaefer L, Iozzo RV. Global impact of proteoglycan science on human diseases. iScience, 26(11): 108095, 2023

Alam S, Afsar SY, Wolter MA, Volk LM, Mitroi DN, Meyer Zu Heringdorf D, and van Echten-Deckert G. S1P Lyase Deficiency in the Brain Promotes Astrogliosis and NLRP3 Inflammasome Activation via Purinergic Signaling. Cells. 12(14): 1844, 2023

Ayoub AM, Atya MS, Abdelsalam AM, Schulze J, Amin MU, Engelhardt K, Wojcik M, Librizzi D, Yousefi BH, Nasrullah U, Pfeilschifter J, Bakowsky U, and Preis E. Photoactive Parietin-loaded nanocarriers as an efficient therapeutic platform against triple-negative breast cancer. Int J Pharm. 643: 123217, 2023  

Beyoğlu D, Schwalm S, Semmo N, Huwiler A, and Idle JR. Hepatitis C Virus Infection Upregulates Plasma Phosphosphingolipids and Endocannabinoids and Downregulates Lysophosphoinositols. Int J Mol Sci. 24(2): 1407, 2023

Büttner S, Zöller C, Patyna S, Gradascevic A, Weiler H, Rosenberg M, Walther T, Zeiher AM, Geiger H, Vasa-Nicotera M, Hauser I, and Fichtlscherer S. Risk of graft loss in kidney transplant recipients after aortic valve replacement. Biomol Biomed., 23(1): 145-152, 2023  

Christen U, Pouzol L, Tunis M, Sassi A, Tondello C, Bayer M, Hintermann E, Strasser DS, Schuldes S, Mentzel U, and Martinic MM. Combination treatment of a novel CXCR3 antagonist ACT-777991 with an anti-CD3 antibody synergistically increases persistent remission in experimental models of type 1 diabetes. Clin Exp Immunol. 214(2): 131-143, 2023  

Nanjundappa RH, Christen U, and Umeshappa CS. Distinct immune surveillance in primary biliary cholangitis and primary sclerosing cholangitis is linked with discrete cholangiocarcinoma risk. Hepatol Commun., 7(9): e0218, 2023

Pöysti S, Silojärvi S, Brodnicki TC, Catterall T, Liu X, Mackin L, Luster AD, Kay TWH, Christen U, Thomas HE, and Hänninen A. Gut dysbiosis promotes islet-autoimmunity by increasing T-cell attraction in islets via CXCL10 chemokine. J Autoimmun., 140: 103090, 2023

Reisbeck L, Linder B, Tascher G, Bozkurt S, Weber KJ, Herold-Mende C, van Wijk SJL, Marschalek R, Schaefer L, Münch C, and Kögel D. The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells. Am J Physiol Cell Physiol., 325(6): C1451-C1469, 2023

Standoli S, Rapino C, Di Meo C, Rudowski A, Kämpfer-Kolb N, Volk LM, Thomas D, Trautmann S, Schreiber Y, Meyer Zu Heringdorf D, and Maccarrone M. Sphingosine Kinases at the Intersection of Pro-Inflammatory LPS and Anti-Inflammatory Endocannabinoid Signaling in BV2 Mouse Microglia Cells. Int J Mol Sci., 24(10): 8508, 2023

Wygrecka M, Hadzic S, Potaczek DP, Alexopoulos I, El Agha E, and Schaefer L. Decoding the role of fatty acids and their metabolites in lung fibrosis. Pol Arch Intern Med. 133(7-8): 16520, 2023

Publikationen 2022

  1. Gonther S, Bachmann M, Goren I, Huard A, Weigert A, Köhl J, and Mühl H. 3’mRNA sequencing reveals pro-regenerative properties of c5ar1 during resolution of murine acetaminophen-induced liver injury. NPJ Regen Med., 7(1): 10, 2022

  2. Schaefer L. New Year Greetings from the Editor-in-Chief of the American Journal of Physiology - Cell Physiology. Am J Physiol Cell Physiol. 322: C122-123, 2022

  3. Jandl K, Mutgan AC, Eller K, Schaefer L, and Kwapiszewska G: The basement membrane in the cross-roads between the lung and kidney. Matrix Biol., 105: 31-52, 2022

  4. Schramm F, Schaefer L, Wygrecka M: EGFR Signaling in Lung Fibrosis. Cells, 11(6), 986, 2022  

  5. Glueck M, Koch A, Brunkhorst R, Ferreiros Bouzas N, Trautmann S, Schaefer L, Pfeilschifter W, Pfeilschifter J, and Vutukuri R. The atypical sphingosine 1-phosphate variant, d16:1 S1P, mediates CTGF induction via S1P2 activation in renal cell carcinoma. FEBS J., 289: 5670-5681, 2022

  6. Eckes T, Patyna S, Koch A, Oftring A, Gauer S, Obermüller N, Schwalm S, Schaefer L, Chun J, Gröne HJ, and Pfeilschifter J. Sphingosine 1-Phosphate Receptor 5 (S1P5) Knockout Ameliorates Adenine-Induced Nephropathy. Int J Mol Sci., 23(7): 3952, 2022

  7. Eichler M, Distler U, Nasrullah U, Krishnan A, Kaulich M, Husnjak K, Eberhardt W, Rajalingam K, Tenzer S, Pfeilschifter J, and Imre G. The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions. Cell Death Dis., 13(4): 386, 2022

  8. Radeke HH, Stein J. Letter: the sphingosine 1 phosphate/sphingosine 1 phosphate receptor axis-a unique therapeutic target in inflammatory bowel disease.  Aliment Pharmacol Ther., 55(10). 1359, 2022

  9. Kis B, Pavel IZ, Avram S, Moaca EA, Herrero San Juan M, Schwiebs A, Radeke HH, Muntean D, Diaconeasa Z, Minda D, Oprean C, Bojin F, Dehelean CA, Soica C, and Danciu C. Antimicrobial activity, in vitro anticancer effect (MCF-7 breast cancer cell line), antiangiogenic and immunomodulatory potentials of Populus nigra L. buds extract. BMC Complement Med Ther., 22(1): 74, 2022

  10. Weber A, Schwiebs A, Solhaug H, Stenvik J, Nilsen AM, Wagner M, Relja B, and Radeke HH. Nanoplastics affect the inflammatory cytokine release by primary human monocytes and dendritic cells. Environ Int., 163: 107173, 2022

  11. Kolbinger A, Kestner RI, Jencio L, Schäufele TJ, Vutukuri R, Pfeilschifter W, and Scholich K. Behind the Wall-Compartment-Specific Neovascularisation during Post-Stroke Recovery in Mice. Cells, 11(10): 1659, 2022

  12. Patyna S, Eckes T, Koch BF, Sudowe S, Oftring A, Kohmer N, Rabenau HF, Ciesek S, Avaniadi D, Steiner R, Hauser IA, Pfeilschifter JM, and Betz C. Impact of Moderna mRNA-1273 Booster Vaccine on Fully Vaccinated High-Risk Chronic Dialysis Patients after Loss of Humoral Response. Vaccines (Basel), 10(4): 585, 2022

  13. Beck KF, Pfeilschifter J. The Pathophysiology of H2S in Renal Glomerular Diseases. Biomolecules, 12(2): 207, 2022

  14. Hafizi R, Imeri F, Stepanovska Tanturovska B, Manaila R, Schwalm S, Trautmann S, Wenger RH, Pfeilschifter J, and Huwiler A. Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells.  Int J Mol Sci., 23(11): 5882, 2022

  15. Hansen L, Lohfink N, Vutukuri R, Kestner RI, Trautmann S, Hecht M, Wagner PV, Spitzer D, Khel MI, Macas J, Ferreirós N, Gurke R, Günther S, Pfeilschifter W, and  Devraj K. Endothelial sphingosine-1-phosphate receptor 4 regulates blood-brain barrier permeability and promotes a homeostatic endothelial phenotype. J Neurosci., 42(10): 1908-1929, 2022

  16. Wygrecka M, Birnhuber A, Seeliger B, Michalick L, Pak O, Schultz AS, Schramm F, Zacharias M, Gorkiewicz G, David S, Welte T, Schmidt JJ, Weissmann N, Schermuly RT, Barreto G, Schaefer L, Markart P, Brack MC, Hippenstiel S, Kurth F, Sander LE, Witzenrath M, Kuebler WM, Kwapiszewska G, and Preissner KT. Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19.  Blood Adv., 6(3): 1074-1087, 2022

  17. Christen U, Hintermann E. Animal Models for Autoimmune Hepatitis: Are Current Models Good Enough? Front Immunol., 13: 898615, 2022

  18. Simpson M, Schaefer L, Hascall V, Esko JD: Hyaluronan. In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Mohnen D, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 4th edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022. Chapter 16.

  19. Bodine SC, Brooks HL, Coller HA, Domingos AI, Frey MR, Goodman BE, Kleyman TR, Lindsey ML, Morty RE, Petersen OH, Ramírez JM, Schaefer L, Thomsen MB, Yosten GLC. An American Physiological Society cross-journal Call for Papers on "The Physiology of Obesity". Am J Physiol Lung Cell Mol Physiol., 323: L593-L602, 2022

  20. Sauer A, Seeliger B, Jandl K,  Fuaadi LE, Wilhelm J, Alexopoulos I,  Baal N, Birnhuber A, David S, Welte T, Barreto G, Kwapiszewska G, Kuebler WM, Schaefer L, and Wygrecka M. Circulating hyaluronic acid signature in CAP and ARDS – the role of pneumolysin in hyaluronic acid shedding. Matrix Biol., 114: 67-83, 2022

  21. Yesilyurt ZE, Matthes J, Hintermann E, Castañeda TR, Elvert R, Beltran-Ornelas JH, Silva-Velasco DL,  Xia N, Kannt A, Christen U, Centurión D, Li H, Pautz A,  Arioglu-Inan E, and Michel MC. Analysis of 16 studies in nine rodent models does not support the hypothesis that diabetic polyuria is a main reason of urinary bladder enlargement. Front Physiol., 13: 923555, 2022

  22. Bora L, Burkard T, Juan MHS, Radeke HH, Muț AM, Vlaia LL, Magyari-Pavel IZ, Diaconeasa Z, Socaci S, Borcan F, Kis B, Muntean D, Dehelean CA, and Danciu C. Phytochemical Characterization and Biological Evaluation of Origanum vulgare L. Essential Oil Formulated as Polymeric Micelles Drug Delivery Systems. Pharmaceutics, 14(11): 2413, 2022

  23. Burkard T, Herrero San Juan M, Dreis C, Kiprina A, Namgaladze D, Siebenbrodt K, Luger S, Foerch C, Pfeilschifter JM, Weigert A, and Radeke HH. Differential expression of CD8 defines phenotypically distinct cytotoxic T cells in cancer and multiple sclerosis. Clin. Transl. Med., 12(12): e1068, 2022

  24. Violatto MB, Pasetto L, Casarin E, Tondello C, Schiavon E, Talamini L, Marchini G, Cagnotto A, Morelli A, Lanno A, Passoni A, Bigini P, Morpurgo M, and Bonetto V. Development of a Nanoparticle-Based Approach for the Blood–Brain Barrier Passage in a Murine Model of Amyotrophic Lateral Sclerosis. Cells, 11(24): 4003, 2022

  25. Kumar R, Pereira RS, Niemann J, Azimpour AI, Zanetti C, Karantanou C, Minka W, Minciacchi VR, Kowarz E, Meister M, Godavarthy PS, Maguer-Satta V, Lefort S, Wiercinska E, Bonig H, Marschalek R, and Krause DS. The differential role of the lipid raft-associated protein flotillin 2 for progression of myeloid leukemia. Blood Adv. 6(12): 3611-3624, 2022

  26. Wagner P, Strodthoff N, Wurzel P, Marban A, Scharf S, Schäfer H, Seegerer P, Loth A, Hartmann S, Klauschen F, Müller KR, Samek W, and Hansmann ML. New definitions of human lymphoid and follicular cell entities in lymphatic tissue by machine learning. Sci Rep., 12(1): 18991, 2022

  27. Bein J, Flinner N, Häupl B, Mathur A, Schneider O, Abu-Ayyad M, Hansmann ML, Piel M, Oellerich T, and Hartmann S. T-cell-derived Hodgkin lymphoma has motility characteristics intermediate between Hodgkin and anaplastic large cell lymphoma. J Cell Mol Med., 26(12): 3495-3505, 2022.

  28. Sadeghi Shoreh Deli A, Scharf S, Steiner Y, Bein J, Hansmann ML, and Hartmann S. 3D analyses reveal T cells with activated nuclear features in T-cell/histiocyte-rich large B-cell lymphoma. Mod Pathol., 35(10): 1431-1438, 2022

  29. Hartmann S, Soltani AS, Bankov K, Bein J, Hansmann ML, Rosenwald A, Bernd HW, Feller A, Ott G, Möller P, Stein H, Klapper W, Borchmann P, Engert A, and Eichenauer DA. Tumour cell characteristics and microenvironment composition correspond to clinical presentation in newly diagnosed nodular lymphocyte-predominant Hodgkin lymphoma.  Br J Haematol., 199(3): 382-391, 2022

Publikationen 2021

  1. Eckes T, Trautmann S, Djudjaj S, Beyer S, Patyna S, Schwalm S, Gauer S, Thomas D, Schaefer L, Boor P, Koch A, Pfeilschifter J. Consistent alteration of chain length-specific ceramides in human and mouse fibrotic kidneys. BBA-Mol Cell Biol Lipids, 1866: 158821, 2021

  2. Monteiro S, Grandt J, Uschner F, Kimer N, Madson JL, Schierwagen R, Klein S, Welsch C, Schaefer L, Jansen C, Claria J, Alceraz-Quiles J, Arroyo V, Moreau R, Fernandez J, Bendsen F, Mehta G, Gluud LL, Moller S, Praktiknjo M, Trebicka J. Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation. Gut, 70: 379-387, 2021

  3. Beck KF, Pfeilschifter J. Gasotransmitter synthesis and signalling in the renal glomerulus. Implications for glomerular diseases. Cell Signal., 77: 109823, 2021

  4. Schwalm S, Beyer S, Hafizi R, Trautmann S, Geisslinger G,  Adams DR, Pyne S, Pyne N, Schaefer L, Huwiler A, Pfeilschifter J. Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis. Cell Signal., 79: 109881, 2021

  5. Wilhelm R, Eckes T, Imre G, Kippenberger S, Meissner M, Thomas, D, Trautmann S, Merlio JP, Chevret E, Kaufmann R, Pfeilschifter J, Koch A, Jäger M. C6 Ceramide (d18:1/6:0) as a Novel Treatment of Cutaneous T Cell Lymphoma. Cancers (Basel), 13(2): 270, 2021

  6. Imeri F, Stepanovska Tanturovska B, Schwalm S, Saha S, Zeng-Brouwers J, Pavenstädt H, Pfeilschifter J, Schaefer L, and  Huwiler A. Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.  Matrix Biol., 98: 32-48, 2021

  7. Schulz M, Diehl V, Trebicka J, Wygrecka M, Schaefer L. Biglycan: a regulator of hepatorenal inflammation and autophagy.  Matrix Biol., 100-101: 150-161, 2021

  8. Schaefer L. Welcome from the new Editor-in-Chief. Am J Physiol. Cell Physiol., 321(1): C1-C2, 2021

  9. Klionsky DJ,…….Schaefer L, …..Tong CK. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy doi: 10.1080/15548627.2020.1797280.

  10. Schaefer L, Dikic I. Autophagy: Instructions from the extracellular matrix. Matrix Biol., 100-101: 1-8, 2021

  11. Huwiler A and Pfeilschifter J. Recuperation of vascular homeostatis.  Editorial, Circ Res., 129: 237-239, 2021

  12. Ortiz C, Schierwagen R, Schaefer L, Klein S, Trepat X, Trebicka J. Extracellular Matrix Remodeling in Chronic Liver Disease. Curr Tissue Microenviron Rep, 2, 41-52, 2021

  13. Ehrlich K, Wilhelm J, Markart P, Weißer H, Wolff J, Bein G, Pak O, Barreto G, Weissmann N, Schramm F, Seeger W, Schaefer L, Kuebler W, Wygrecka M, and Capnetz Study Group. Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community acquired pneumonia. AJP-Lung Physiol., 321(4):L764-L774, 2021

  14. Imre G, Krähling V, Eichler M, Trautmann S, Ferreirós N, Aman MJ, Kashanchi F, Rajalingam K, Pöhlmann S, Becker S, Meyer Zu Heringdorf D, and Pfeilschifter J. The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection. iScience, 24(4), 102266, 2021

  15. Eichler M, Aksi E, Pfeilschifter J, and Imre G. Application of pseudotyped virus particles to monitor Ebola virus and SARS-CoV-2 viral entry in human cell lines. STAR protocols, 2(4), 100818, 2021

  16. Stülb H, Bachmann M, Gonther S, and Mühl H. Acetaminophen-induced liver injury exposes murine IL-22 as sex-related gene product. Int J Mol Sci, 22(19): 10623, 2021

  17. Burkard T, Dreis C, Herrero San Juan M, Huhn M, Weigert A, Pfeilschifter JM, and Radeke HH. Enhanced CXCR4 Expression of Human CD8Low T Lymphocytes Is Driven by S1P4. Front Immunol, 12(3435): 668884, 2021

  18. Schwiebs A, Faqar-Uz-Zaman F, Herrero San Juan M, and Radeke HH. S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3. Int J Mol Sci. 22(11): 5682, 2021

  19. Faqar-Uz-Zaman WF, Schmidt KG, Thomas D, Pfeilschifter JM, Radeke HH, and Schwiebs A. S1P Lyase siRNA Dampens Malignancy of DLD-1 Colorectal Cancer Cells. Lipids, 56(2): 155-166, 2021

  20. Diehl V, Huber LS, Trebicka J, Wygrecka M, Iozzo RV, and Schaefer L. The role of decorin and biglycan signaling in tumorigenesis. Frontiers in Oncology, 11: 801801, 2021

  21. Spohner AK, Jakobi K, Trautmann S, Thomas D, Schumacher F, Kleuser B, Lütjohann D, El-Hindi K, Grösch S, Pfeilschifter J, Saba JD, and Meyer Zu Heringdorf D. Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile. Int J Mol Sci., 22(19): 10617, 2021

  22. Imeri F, Stepanovska Tanturovska B, Zivkovic A, Enzmann G, Schwalm S, Pfeilschifter J, Homann T, Kleuser B, Engelhardt B, Stark H, and Huwiler A. Novel compounds with dual S1P receptor agonist and histamine H3 receptor antagonist activities act protective in a mouse model of multiple sclerosis. Neuropharmacology, 186: 108464, 2021

  23. Roedig J, Kowald L, Juretschke T, Karlowitz R, Ahangarian Abhari B, Roedig H, Fulda S, Beli P, and van Wijk SJ. USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination. EMBO Rep., 22(2): e50163, 2021.

  24. Diehl V, Wegner M, Grumati P, Husnjak K, Schaubeck S, Gubas A, Shah VJ, Polat IH, Langschied F, Prieto-Garcia C, Müller K, Kalousi A, Ebersberger I, Brandts CH, Dikic I, and Kaulich M. Minimized combinatorial CRISPR screens identify genetic interactions in autophagy. Nucleic Acids Res., 49(10): 5684-5704, 2021

  25. Amin MU, Ali S, Ali MY, Tariq I, Nasrullah U, Pinnapreddy SR, Wölk C, Bakowsky U, and Brüßler J. Enhanced efficacy and drug delivery with lipid coated mesoporous silica nanoparticles in cancer therapy. Eur J Pharm Biopharm., 165: 31-40, 2021

  26. Shah HS, Nasrullah U, Zaib S, Usman F, Khan A, Gohar UF, Uddin J, Khan I, and Al-Harrasi A. Preparation, Characterization, and Pharmacological Investigation of Withaferin-A Loaded Nanosponges for Cancer Therapy; In Vitro, In Vivo and Molecular Docking Studies. Molecules, 26(22): 6990, 2021

  27. Delgado Lagos F, Elgheznawy A, Kyselova A, Meyer Zu Heringdorf D, Ratiu C, Randriamboavonjy V, Mann AW, Fisslthaler B, Siragusa M, and Fleming I. Secreted modular calcium-binding protein 1 binds and activates thrombin to account for platelet hyperreactivity in diabetes. Blood, 137(12): 1641-1651, 2021

 

Publikationen 2020

  1. Vutukuri R, Koch A, Trautmann S, Schreiber Y, Thomas D, Mayser F, Meyer Zu Heringdorf D, Pfeilschifter J, Pfeilschifter W, Brunkhorst R. S1P d20:1, an endogenous modulator of S1P d18:1/S1P(2) -dependent signaling. FASEB J., 34(3): 3932-3942, 2020

  2. Krämer M, Markart P, Drakopanagiotakis F, Mamazhakypov A, Schaefer L, Didiasova M, Wygrecka M. Pirfenidone inhibits motility of NSCLC cells by interfering with the urokinase system. Cell Signal. 65: 109432, 2020 

  3. Meschede J, Šadić M, Furthmann N, Miedema T, Sehr DA, Müller-Rischart AK, Bader V, Berlemann LA, Pilsl A, Schlierf A, Barkovits K, Kachholz B, Rittinger K, Ikeda F, Marcus K, Schaefer L, Tatzelt J, Winklhofer KF. The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC. Sci Signal., 13(617), 2020

  4. Roedig H, Damiescu R, Zeng-Brouwers J, Kutija I, Trebicka J, Wygrecka M, Schaefer L. Danger matrix molecules orchestrate CD14/CD44 signaling in cancer development. Semin Cancer Biol, 62: 31-47, 2020

  5. Wygrecka M and Schaefer L. Between life and death: Epithelial cells in lung pathologies. Cell Signal 72: 109652, 2020

  6. Rudloff I, Jarde T, Bachmann M, Elgass KD, Kerr G, Engel R, Richards E, Oliva K, Wilkins S, McMurrick PJ, Abud HE, Mühl H, Nold MF. Molecular signature of interleukin-22 in colon carcinoma cells and organoid models. Transl Res., 216: 1-22, 2020

  7. Madhusudhan T, Ghosh S, Wang H, Wie D, Gupta D, Stoyanov S, Elwakiel A, Al-Dabet MM, Krishnan S, Kohli S, Biemann R, Nazir S, Zimmermann S, Mathew A, Gadi IUR, Rana R, Zeng-Brouwers J, Möller M, Schaefer L, Esmon C, Reiser J, Rezaie A, Ruf W, Isermann B. Integrin αvβ3 on podocytes orchestrates coagulation protease signaling through protease-activated receptors. J Am Soc Nephrol., 31(8): 1762-1780, 2020 

  8. Zeng-Brouwers J, Pandey S, Trebicka J, Wygrecka M, Schaefer L. Communications via the small leucine-rich proteoglycans: Molecular sp