Alcober-Boquet L, Kraus N, Huber LS, Vutukuri R, Fuhrmann DC, Stross C, Schaefer L, Scholich K, Zeuzem S, Piiper A, Schulz MH, Trebicka J, Welsch C, and Ortiz C. BI-3231, an enzymatic inhibitor of HSD17B13, reduces lipotoxic effects induced by palmitic acid in murine and human hepatocytes. Am J Physiol Cell Physiol., 326(3): C880-C892, 2024 

Raith J, Bachmann M, Gonther S, Stülb H, Aghdassi AA, Pham CTN, and Mühl H. Targeting cathepsin C ameliorates murine acetaminophen-induced liver injury. Theranostics, 14(8): 3029-3042, 2024

Shah HS, Zaib S, Usman F, Sarfraz M, Faiz R, Rehman SA, Khan AA, Alanazi AM, Khan R, Nasrullah U, Nazir I. Synthesis, characterization, pharmacological and computational evaluation of hyaluronic acid modified chebulinic acid encapsulated chitosan nanocomposite for cancer therapy. Int J Biol Macromol., 263(Pt 1): 130160, 2024

Bender C, Müller P, Tondello C, Horn J, Holdener M, Lasch S, Bayer M, Pfeilschifter JM, Tacke F, Ludwig A, Hansmann ML, Döring C, Hintermann E, and Christen U. Gene-expression profiling of laser-dissected islets and studies in deficient mice reveal chemokines as differential driving force of type 1 diabetes. J Autoimmun., 143: 103161, 2024

Hintermann E, Tondello C, Fuchs S, Bayer M, Pfeilschifter JM, Taubert R, Mollenhauer M, Elferink RPJO, Manns MP, and Christen U. Blockade of neutrophil extracellular trap components ameliorates cholestatic liver disease in Mdr2 (Abcb4) knockout mice. J Autoimmun., 146: 103229, 2024

Schmithals C, Kakoschky B, Denk D, von Harten M, Klug JH, Hintermann E, Dropmann A, Hamza E, Jacomin AC, Marquardt JU, Zeuzem S, Schirmacher P, Herrmann E, Christen U, Vogl TJ, Waidmann O, Dooley S, Finkelmeier F, and Piiper A. Tumour-specific activation of a tumour-blood transport improves the diagnostic accuracy of blood tumour markers in mice. EBioMedicine, 105: 105178, 2024  

Pfeilschifter J and Gulbins E. Tribute to Andrea Huwiler (1966-2023). Pflugers Arch. 2024 Apr 9. doi: 10.1007/s00424-024-02958-5. Epub ahead of print. PMID: 38592461.

Merline R and Schaefer L. A novel regulator of selective autophagy: TNIP1/ABIN-1 modulates mitophagy. Autophagy Reports KAUO, doi: 10.1080/27694127.2023.2165269, 2023

Nold SP, Sych K, Imre G, Fuhrmann DC, Pfeilschifter J, Vutukuri R, Schnutgen F, Wittig I, Meisterknecht J, Frank S, and Goren I. Reciprocal abrogation of PKM isoforms: Contradictory outcomes and differing impact of splicing signal on CRISPR/Cas9 mediates gene editing in keratinocytes. FEBS J., 290(9): 2338-2365, 2023 

Merline R, Roedig H, Zeng-Brouwers J, Poluzzi C, Tascher G, Michaelis J, Lopez-Mosqueda J, Huber LS, Diehl V, Dikic I, Kögel D, Münch C, Wygrecka M, and Schaefer L. A20 binding and inhibitor of NFkB (ABIN-1) - a novel modulator of mitochondrial autophagy. Am J Physiol-Cell Physiol., 324(2): C339-C352, 2023

Wygrecka M, Alexopoulos I, Potaczek DP, and Schaefer L. Diverse Functions of Apolipoprotein A-I in Lung Fibrosis. Am J Physiol. Cell Physiol., 324(2): C438-C446, 2023  

Sych K, Nold SP, Pfeilschifter J, Vutukuri R, Meisterknecht J, Wittig I, Frank S and  Goren I. Expression of PKM2 in wound keratin ocytes is coupled to angiogenesis during skin repair in vivo and in HaCaT keratinocytes in vitro. J Mol.Med.(Berl), 101(1-2): 151-169, 2023

Zeng-Brouwers J, Huber LS, Merline R, Trebicka J, Wygrecka M, and Schaefer L. Evaluation of the In Vitro and In Vivo Effects of Biglycan in Innate Immunity. Methods Mol Biol., 2619: 109-124, 2023

Delpire E, Hawke T, Karthikeyan M, Kong W, Nyström A, Uchida S, and Schaefer L: American Journal of Physiology-Cell Physiology in 2022: at a glance. Am J Physiol Cell Physiol, 324(2): C553-C557, 2023.

Ballhausen A, Ben Hamza A, Welters C, Dietze K, Bullinger L, Rahn HP, Hartmann S, Hansmann ML, and Hansmann L. Immune phenotypes and checkpoint molecule expression of clonally expanded lymph node-infiltrating T cells in classical Hodgkin lymphoma. Cancer Immunol Immunother., 72(2): 515-521, 2023

Schaefer L and Pierre SV. Cell and Molecular Physiology Section of the American Physiological Society in connection with American Journal of Physiology-Cell Physiology. Am J Physiol Cell Physiol., 325(1): C362-C363, 2023

Nasrullah U, Stanke K, Recknagel V, Bozkurt S, Wurzel P, Gauer S, Imre G, Münch C, Pfeilschifter J, and Eberhardt W. The E3 Ligase TRIM25 Impairs Apoptotic Cell Death in Colon Carcinoma Cells via Destabilization of Caspase-7 mRNA: A Possible Role of hnRNPH1. Cells, 12(1): 201, 2023

Li Z, Xia H, Sharp TE 3rd, LaPenna KB, Katsouda A, Elrod JW, Pfeilschifter J, Beck KF, Xu S, Xian M, Goodchild TT, Papapetropoulos A, and Lefer DJ. Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure. Circ Res., 132(2): 154-166, 2023

Röhrig AM, Jakobi K, Dietz J, Thomas D, Herrmann E, Welsch C, Sarrazin C, Pfeilschifter J, Zeuzem S, and Grammatikos G. The role of serum sphingolipids as potential biomarkers of non-response to direct acting antiviral therapy in chronic hepatitis C virus infection. J Viral Hepat., 30(2): 138-147, 2023

Imeri F, Tanturovska, BS, Manaila R, Pavenstädt H, Pfeilschifter J, and Huwiler A. Loss of S1P Lyase expression in human podocytes causes a reduction in nephrin expression that involves PKC activation. Int J Mol Sci., 24, 3267, 2023

Scharf S, Ackermann J, Bender L, Wurzel P, Schäfer H, Hansmann ML, and Koch, I. Holistic View on the Structure of Immune Response: Petri Net Model. Biomedicines, 11(2), 452, 2023

Hansmann ML, Klauschen F, Samek W, Müller KR, Donnadieu E, Scharf S, Hartmann Sy, Koch I, Ackermann J, Pantanowitz L, Schäfer H, and Wurzel P. Imaging bridges pathology and radiology, Journal of Pathology Informatics, Volume 14,100298, ISSN 2153-3539, 2023

Huwiler A, Beck KF, and Pfeilschifter J. Cross-regulation of the cellular redox system, oxygen, and sphingolipid signalling. Metabolites, 13(3): 426, 2023

Shainer R, Kram V, Kilts TM, Li L, Doyle AD, Shainer I, Martin D, Simon CG Jr, Zeng-Brouwers J, Schaefer L, and Young MF. Genomics and Computational Biology Core. Biglycan regulates bone development and regeneration. Front Physiol.,14: 1119368, 2023

Miethe S, Potaczek DP, Bazan-Socha S, Bachl M, Schaefer L, Wygrecka M, and Garn H. The emerging role of extracellular vesicles as communicators between adipose tissue and pathologic lungs with a special focus on asthma. Am J Physiol Cell Physiol., 324(5): C1119-C1125, 2023

Schierwagen R, Gu W, Brieger A, Brüne B, Ciesek S, Đikić I, Dimmeler S, Geisslinger G, Greten FR, Herrmann E, Hildt E, Kempf VAJ, Klein S, Koch I, Mühl H, Müller V, Peiffer KH, Kestner RI, Piiper A, Rohde G, Scholich K, Schulz MH, Storf H, Toptan T, Vasa-Nicotera M, Vehreschild MJGT, Weigert A, Wild PJ, Zeuzem S, Engelmann C; ACLF-I investigators; Schaefer L, Welsch C, and Trebicka J. Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure. Am J Physiol Cell Physiol., 325(1): C129-C140, 2023

Erdogan BR, Michel MB, Matthes J, Castañeda TR, Christen U, Arioglu-Inan E, Michel MC, and Pautz A. A comparison of urinary bladder weight in male and female mice across five models of diabetes and obesity. Front Pharmacol., 14: 1118730, 2023

Schemel CM, Wurzel P, Scharf S, Schäfer H, Hartmann S, Koch I and Hansmann ML. Three-dimensional human germinal centers of different sizes in patients diagnosed with lymphadenitis show comparative constant relative volumes of B cells, T cells, follicular dendritic cells, and macrophages. Acta Histochemica, 125(7), 152075, 2023

Merk-Ahmad K, Bein J, Scharf S, Schäfer H, Bexte T, Ullrich E, Loth AG, Flinner N, Senff T, Schneider O, Hansmann ML, Piel M, Häupl B, Oellerich T, Donnadieu E, and Hartmann S. The RHOA Mutation G17V Does Not Lead to Increased Migration of Human Malignant T Cells but Is Associated with Matrix Remodelling. Cancers (Basel), 15(12): 3226, 2023

Anzaghe M, Niles MA, Korotkova E, Dominguez M, Kronhart S, Bechmann I, Bachmann M, Mühl, H, Kochs G, and Waibler Z. Interleukin-36γ is causative for liver damage upon infection with Rift Valley fever virus in type I interferon receptor-deficient mice. Front Immunol, 14: 1194733. 2023

Nyström A, Schaefer L. An American Journal of Physiology-Cell Physiology for the present and the future. Am J Physiol. Cell Physiol., 325(5): C1155-C11572023, 2023

Xie Ch, Schaefer L, Iozzo RV. Global impact of proteoglycan science on human diseases. iScience, 26(11): 108095, 2023

Alam S, Afsar SY, Wolter MA, Volk LM, Mitroi DN, Meyer Zu Heringdorf D, and van Echten-Deckert G. S1P Lyase Deficiency in the Brain Promotes Astrogliosis and NLRP3 Inflammasome Activation via Purinergic Signaling. Cells. 12(14): 1844, 2023

Ayoub AM, Atya MS, Abdelsalam AM, Schulze J, Amin MU, Engelhardt K, Wojcik M, Librizzi D, Yousefi BH, Nasrullah U, Pfeilschifter J, Bakowsky U, and Preis E. Photoactive Parietin-loaded nanocarriers as an efficient therapeutic platform against triple-negative breast cancer. Int J Pharm. 643: 123217, 2023  

Beyoğlu D, Schwalm S, Semmo N, Huwiler A, and Idle JR. Hepatitis C Virus Infection Upregulates Plasma Phosphosphingolipids and Endocannabinoids and Downregulates Lysophosphoinositols. Int J Mol Sci. 24(2): 1407, 2023

Büttner S, Zöller C, Patyna S, Gradascevic A, Weiler H, Rosenberg M, Walther T, Zeiher AM, Geiger H, Vasa-Nicotera M, Hauser I, and Fichtlscherer S. Risk of graft loss in kidney transplant recipients after aortic valve replacement. Biomol Biomed., 23(1): 145-152, 2023  

Christen U, Pouzol L, Tunis M, Sassi A, Tondello C, Bayer M, Hintermann E, Strasser DS, Schuldes S, Mentzel U, and Martinic MM. Combination treatment of a novel CXCR3 antagonist ACT-777991 with an anti-CD3 antibody synergistically increases persistent remission in experimental models of type 1 diabetes. Clin Exp Immunol. 214(2): 131-143, 2023  

Nanjundappa RH, Christen U, and Umeshappa CS. Distinct immune surveillance in primary biliary cholangitis and primary sclerosing cholangitis is linked with discrete cholangiocarcinoma risk. Hepatol Commun., 7(9): e0218, 2023

Pöysti S, Silojärvi S, Brodnicki TC, Catterall T, Liu X, Mackin L, Luster AD, Kay TWH, Christen U, Thomas HE, and Hänninen A. Gut dysbiosis promotes islet-autoimmunity by increasing T-cell attraction in islets via CXCL10 chemokine. J Autoimmun., 140: 103090, 2023

Reisbeck L, Linder B, Tascher G, Bozkurt S, Weber KJ, Herold-Mende C, van Wijk SJL, Marschalek R, Schaefer L, Münch C, and Kögel D. The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells. Am J Physiol Cell Physiol., 325(6): C1451-C1469, 2023

Standoli S, Rapino C, Di Meo C, Rudowski A, Kämpfer-Kolb N, Volk LM, Thomas D, Trautmann S, Schreiber Y, Meyer Zu Heringdorf D, and Maccarrone M. Sphingosine Kinases at the Intersection of Pro-Inflammatory LPS and Anti-Inflammatory Endocannabinoid Signaling in BV2 Mouse Microglia Cells. Int J Mol Sci., 24(10): 8508, 2023

Wygrecka M, Hadzic S, Potaczek DP, Alexopoulos I, El Agha E, and Schaefer L. Decoding the role of fatty acids and their metabolites in lung fibrosis. Pol Arch Intern Med. 133(7-8): 16520, 2023

1. Gonther S, Bachmann M, Goren I, Huard A, Weigert A, Köhl J, and Mühl H. 3’mRNA sequencing reveals pro-regenerative properties of c5ar1 during resolution of murine acetaminophen-induced liver injury. NPJ Regen Med., 7(1): 10, 2022

2. Schaefer L. New Year Greetings from the Editor-in-Chief of the American Journal of Physiology - Cell Physiology. Am J Physiol Cell Physiol. 322: C122-123, 2022

3. Jandl K, Mutgan AC, Eller K, Schaefer L, and Kwapiszewska G: The basement membrane in the cross-roads between the lung and kidney. Matrix Biol., 105: 31-52, 2022

4. Schramm F, Schaefer L, Wygrecka M: EGFR Signaling in Lung Fibrosis. Cells, 11(6), 986, 2022  

5. Glueck M, Koch A, Brunkhorst R, Ferreiros Bouzas N, Trautmann S, Schaefer L, Pfeilschifter W, Pfeilschifter J, and Vutukuri R. The atypical sphingosine 1-phosphate variant, d16:1 S1P, mediates CTGF induction via S1P2 activation in renal cell carcinoma. FEBS J., 289: 5670-5681, 2022

6. Eckes T, Patyna S, Koch A, Oftring A, Gauer S, Obermüller N, Schwalm S, Schaefer L, Chun J, Gröne HJ, and Pfeilschifter J. Sphingosine 1-Phosphate Receptor 5 (S1P₅) Knockout Ameliorates Adenine-Induced Nephropathy. Int J Mol Sci., 23(7): 3952, 2022

7. Eichler M, Distler U, Nasrullah U, Krishnan A, Kaulich M, Husnjak K, Eberhardt W, Rajalingam K, Tenzer S, Pfeilschifter J, and Imre G. The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions. Cell Death Dis., 13(4): 386, 2022

8. Radeke HH, Stein J. Letter: the sphingosine 1 phosphate/sphingosine 1 phosphate receptor axis-a unique therapeutic target in inflammatory bowel disease.  Aliment Pharmacol Ther., 55(10). 1359, 2022

9. Kis B, Pavel IZ, Avram S, Moaca EA, Herrero San Juan M, Schwiebs A, Radeke HH, Muntean D, Diaconeasa Z, Minda D, Oprean C, Bojin F, Dehelean CA, Soica C, and Danciu C. Antimicrobial activity, in vitro anticancer effect (MCF-7 breast cancer cell line), antiangiogenic and immunomodulatory potentials of Populus nigra L. buds extract. BMC Complement Med Ther., 22(1): 74, 2022

10. Weber A, Schwiebs A, Solhaug H, Stenvik J, Nilsen AM, Wagner M, Relja B, and Radeke HH. Nanoplastics affect the inflammatory cytokine release by primary human monocytes and dendritic cells. Environ Int., 163: 107173, 2022

11. Kolbinger A, Kestner RI, Jencio L, Schäufele TJ, Vutukuri R, Pfeilschifter W, and Scholich K. Behind the Wall-Compartment-Specific Neovascularisation during Post-Stroke Recovery in Mice. Cells, 11(10): 1659, 2022

12. Patyna S, Eckes T, Koch BF, Sudowe S, Oftring A, Kohmer N, Rabenau HF, Ciesek S, Avaniadi D, Steiner R, Hauser IA, Pfeilschifter JM, and Betz C. Impact of Moderna mRNA-1273 Booster Vaccine on Fully Vaccinated High-Risk Chronic Dialysis Patients after Loss of Humoral Response. Vaccines (Basel), 10(4): 585, 2022

13. Beck KF, Pfeilschifter J. The Pathophysiology of H₂S in Renal Glomerular Diseases. Biomolecules, 12(2): 207, 2022

14. Hafizi R, Imeri F, Stepanovska Tanturovska B, Manaila R, Schwalm S, Trautmann S, Wenger RH, Pfeilschifter J, and Huwiler A. Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells.  Int J Mol Sci., 23(11): 5882, 2022

15. Hansen L, Lohfink N, Vutukuri R, Kestner RI, Trautmann S, Hecht M, Wagner PV, Spitzer D, Khel MI, Macas J, Ferreirós N, Gurke R, Günther S, Pfeilschifter W, and  Devraj K. Endothelial sphingosine-1-phosphate receptor 4 regulates blood-brain barrier permeability and promotes a homeostatic endothelial phenotype. J Neurosci., 42(10): 1908-1929, 2022

16. Wygrecka M, Birnhuber A, Seeliger B, Michalick L, Pak O, Schultz AS, Schramm F, Zacharias M, Gorkiewicz G, David S, Welte T, Schmidt JJ, Weissmann N, Schermuly RT, Barreto G, Schaefer L, Markart P, Brack MC, Hippenstiel S, Kurth F, Sander LE, Witzenrath M, Kuebler WM, Kwapiszewska G, and Preissner KT. Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19.  Blood Adv., 6(3): 1074-1087, 2022

17. Christen U, Hintermann E. Animal Models for Autoimmune Hepatitis: Are Current Models Good Enough? Front Immunol., 13: 898615, 2022

18. Simpson M, Schaefer L, Hascall V, Esko JD: Hyaluronan. In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Mohnen D, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 4th edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022. Chapter 16.

19. Bodine SC, Brooks HL, Coller HA, Domingos AI, Frey MR, Goodman BE, Kleyman TR, Lindsey ML, Morty RE, Petersen OH, Ramírez JM, Schaefer L, Thomsen MB, Yosten GLC. An American Physiological Society cross-journal Call for Papers on "The Physiology of Obesity". Am J Physiol Lung Cell Mol Physiol., 323: L593-L602, 2022

20. Sauer A, Seeliger B, Jandl K,  Fuaadi LE, Wilhelm J, Alexopoulos I,  Baal N, Birnhuber A, David S, Welte T, Barreto G, Kwapiszewska G, Kuebler WM, Schaefer L, and Wygrecka M. Circulating hyaluronic acid signature in CAP and ARDS – the role of pneumolysin in hyaluronic acid shedding. Matrix Biol., 114: 67-83, 2022

21. Yesilyurt ZE, Matthes J, Hintermann E, Castañeda TR, Elvert R, Beltran-Ornelas JH, Silva-Velasco DL,  Xia N, Kannt A, Christen U, Centurión D, Li H, Pautz A,  Arioglu-Inan E, and Michel MC. Analysis of 16 studies in nine rodent models does not support the hypothesis that diabetic polyuria is a main reason of urinary bladder enlargement. Front Physiol., 13: 923555, 2022

22. Bora L, Burkard T, Juan MHS, Radeke HH, Muț AM, Vlaia LL, Magyari-Pavel IZ, Diaconeasa Z, Socaci S, Borcan F, Kis B, Muntean D, Dehelean CA, and Danciu C. Phytochemical Characterization and Biological Evaluation of Origanum vulgare L. Essential Oil Formulated as Polymeric Micelles Drug Delivery Systems. Pharmaceutics, 14(11): 2413, 2022

23. Burkard T, Herrero San Juan M, Dreis C, Kiprina A, Namgaladze D, Siebenbrodt K, Luger S, Foerch C, Pfeilschifter JM, Weigert A, and Radeke HH. Differential expression of CD8 defines phenotypically distinct cytotoxic T cells in cancer and multiple sclerosis. Clin. Transl. Med., 12(12): e1068, 2022

24. Violatto MB, Pasetto L, Casarin E, Tondello C, Schiavon E, Talamini L, Marchini G, Cagnotto A, Morelli A, Lanno A, Passoni A, Bigini P, Morpurgo M, and Bonetto V. Development of a Nanoparticle-Based Approach for the Blood–Brain Barrier Passage in a Murine Model of Amyotrophic Lateral Sclerosis. Cells, 11(24): 4003, 2022

25. Kumar R, Pereira RS, Niemann J, Azimpour AI, Zanetti C, Karantanou C, Minka W, Minciacchi VR, Kowarz E, Meister M, Godavarthy PS, Maguer-Satta V, Lefort S, Wiercinska E, Bonig H, Marschalek R, and Krause DS. The differential role of the lipid raft-associated protein flotillin 2 for progression of myeloid leukemia. Blood Adv. 6(12): 3611-3624, 2022

26. Wagner P, Strodthoff N, Wurzel P, Marban A, Scharf S, Schäfer H, Seegerer P, Loth A, Hartmann S, Klauschen F, Müller KR, Samek W, and Hansmann ML. New definitions of human lymphoid and follicular cell entities in lymphatic tissue by machine learning. Sci Rep., 12(1): 18991, 2022

27. Bein J, Flinner N, Häupl B, Mathur A, Schneider O, Abu-Ayyad M, Hansmann ML, Piel M, Oellerich T, and Hartmann S. T-cell-derived Hodgkin lymphoma has motility characteristics intermediate between Hodgkin and anaplastic large cell lymphoma. J Cell Mol Med., 26(12): 3495-3505, 2022.

28. Sadeghi Shoreh Deli A, Scharf S, Steiner Y, Bein J, Hansmann ML, and Hartmann S. 3D analyses reveal T cells with activated nuclear features in T-cell/histiocyte-rich large B-cell lymphoma. Mod Pathol., 35(10): 1431-1438, 2022

29. Hartmann S, Soltani AS, Bankov K, Bein J, Hansmann ML, Rosenwald A, Bernd HW, Feller A, Ott G, Möller P, Stein H, Klapper W, Borchmann P, Engert A, and Eichenauer DA. Tumour cell characteristics and microenvironment composition correspond to clinical presentation in newly diagnosed nodular lymphocyte-predominant Hodgkin lymphoma.  Br J Haematol., 199(3): 382-391, 2022

1. Eckes T, Trautmann S, Djudjaj S, Beyer S, Patyna S, Schwalm S, Gauer S, Thomas D, Schaefer L, Boor P, Koch A, Pfeilschifter J. Consistent alteration of chain length-specific ceramides in human and mouse fibrotic kidneys. BBA-Mol Cell Biol Lipids, 1866: 158821, 2021

2. Monteiro S, Grandt J, Uschner F, Kimer N, Madson JL, Schierwagen R, Klein S, Welsch C, Schaefer L, Jansen C, Claria J, Alceraz-Quiles J, Arroyo V, Moreau R, Fernandez J, Bendsen F, Mehta G, Gluud LL, Moller S, Praktiknjo M, Trebicka J. Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation. Gut, 70: 379-387, 2021

3. Beck KF, Pfeilschifter J. Gasotransmitter synthesis and signalling in the renal glomerulus. Implications for glomerular diseases. Cell Signal., 77: 109823, 2021

4. Schwalm S, Beyer S, Hafizi R, Trautmann S, Geisslinger G,  Adams DR, Pyne S, Pyne N, Schaefer L, Huwiler A, Pfeilschifter J. Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis. Cell Signal., 79: 109881, 2021

5. Wilhelm R, Eckes T, Imre G, Kippenberger S, Meissner M, Thomas, D, Trautmann S, Merlio JP, Chevret E, Kaufmann R, Pfeilschifter J, Koch A, Jäger M. C6 Ceramide (d18:1/6:0) as a Novel Treatment of Cutaneous T Cell Lymphoma. Cancers (Basel), 13(2): 270, 2021

6. Imeri F, Stepanovska Tanturovska B, Schwalm S, Saha S, Zeng-Brouwers J, Pavenstädt H, Pfeilschifter J, Schaefer L, and  Huwiler A. Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.  Matrix Biol., 98: 32-48, 2021

7. Schulz M, Diehl V, Trebicka J, Wygrecka M, Schaefer L. Biglycan: a regulator of hepatorenal inflammation and autophagy.  Matrix Biol., 100-101: 150-161, 2021

8. Schaefer L. Welcome from the new Editor-in-Chief. Am J Physiol. Cell Physiol., 321(1): C1-C2, 2021

9. Klionsky DJ,…….Schaefer L, …..Tong CK. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy doi: 10.1080/15548627.2020.1797280.

10. Schaefer L, Dikic I. Autophagy: Instructions from the extracellular matrix. Matrix Biol., 100-101: 1-8, 2021

11. Huwiler A and Pfeilschifter J. Recuperation of vascular homeostatis.  Editorial, Circ Res., 129: 237-239, 2021

12. Ortiz C, Schierwagen R, Schaefer L, Klein S, Trepat X, Trebicka J. Extracellular Matrix Remodeling in Chronic Liver Disease. Curr Tissue Microenviron Rep, 2, 41-52, 2021

13. Ehrlich K, Wilhelm J, Markart P, Weißer H, Wolff J, Bein G, Pak O, Barreto G, Weissmann N, Schramm F, Seeger W, Schaefer L, Kuebler W, Wygrecka M, and Capnetz Study Group. Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community acquired pneumonia. AJP-Lung Physiol., 321(4):L764-L774, 2021

14. Imre G, Krähling V, Eichler M, Trautmann S, Ferreirós N, Aman MJ, Kashanchi F, Rajalingam K, Pöhlmann S, Becker S, Meyer Zu Heringdorf D, and Pfeilschifter J. The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection. iScience, 24(4), 102266, 2021

15. Eichler M, Aksi E, Pfeilschifter J, and Imre G. Application of pseudotyped virus particles to monitor Ebola virus and SARS-CoV-2 viral entry in human cell lines. STAR protocols, 2(4), 100818, 2021

16. Stülb H, Bachmann M, Gonther S, and Mühl H. Acetaminophen-induced liver injury exposes murine IL-22 as sex-related gene product. Int J Mol Sci, 22(19): 10623, 2021

17. Burkard T, Dreis C, Herrero San Juan M, Huhn M, Weigert A, Pfeilschifter JM, and Radeke HH. Enhanced CXCR4 Expression of Human CD8Low T Lymphocytes Is Driven by S1P4. Front Immunol, 12(3435): 668884, 2021

18. Schwiebs A, Faqar-Uz-Zaman F, Herrero San Juan M, and Radeke HH. S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3. Int J Mol Sci. 22(11): 5682, 2021

19. Faqar-Uz-Zaman WF, Schmidt KG, Thomas D, Pfeilschifter JM, Radeke HH, and Schwiebs A. S1P Lyase siRNA Dampens Malignancy of DLD-1 Colorectal Cancer Cells. Lipids, 56(2): 155-166, 2021

20. Diehl V, Huber LS, Trebicka J, Wygrecka M, Iozzo RV, and Schaefer L. The role of decorin and biglycan signaling in tumorigenesis. Frontiers in Oncology, 11: 801801, 2021

21. Spohner AK, Jakobi K, Trautmann S, Thomas D, Schumacher F, Kleuser B, Lütjohann D, El-Hindi K, Grösch S, Pfeilschifter J, Saba JD, and Meyer Zu Heringdorf D. Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile. Int J Mol Sci., 22(19): 10617, 2021

22. Imeri F, Stepanovska Tanturovska B, Zivkovic A, Enzmann G, Schwalm S, Pfeilschifter J, Homann T, Kleuser B, Engelhardt B, Stark H, and Huwiler A. Novel compounds with dual S1P receptor agonist and histamine H₃ receptor antagonist activities act protective in a mouse model of multiple sclerosis. Neuropharmacology, 186: 108464, 2021

23. Roedig J, Kowald L, Juretschke T, Karlowitz R, Ahangarian Abhari B, Roedig H, Fulda S, Beli P, and van Wijk SJ. USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination. EMBO Rep., 22(2): e50163, 2021.

24. Diehl V, Wegner M, Grumati P, Husnjak K, Schaubeck S, Gubas A, Shah VJ, Polat IH, Langschied F, Prieto-Garcia C, Müller K, Kalousi A, Ebersberger I, Brandts CH, Dikic I, and Kaulich M. Minimized combinatorial CRISPR screens identify genetic interactions in autophagy. Nucleic Acids Res., 49(10): 5684-5704, 2021

25. Amin MU, Ali S, Ali MY, Tariq I, Nasrullah U, Pinnapreddy SR, Wölk C, Bakowsky U, and Brüßler J. Enhanced efficacy and drug delivery with lipid coated mesoporous silica nanoparticles in cancer therapy. Eur J Pharm Biopharm., 165: 31-40, 2021

26. Shah HS, Nasrullah U, Zaib S, Usman F, Khan A, Gohar UF, Uddin J, Khan I, and Al-Harrasi A. Preparation, Characterization, and Pharmacological Investigation of Withaferin-A Loaded Nanosponges for Cancer Therapy; In Vitro, In Vivo and Molecular Docking Studies. Molecules, 26(22): 6990, 2021

27. Delgado Lagos F, Elgheznawy A, Kyselova A, Meyer Zu Heringdorf D, Ratiu C, Randriamboavonjy V, Mann AW, Fisslthaler B, Siragusa M, and Fleming I. Secreted modular calcium-binding protein 1 binds and activates thrombin to account for platelet hyperreactivity in diabetes. Blood, 137(12): 1641-1651, 2021

1. Vutukuri R, Koch A, Trautmann S, Schreiber Y, Thomas D, Mayser F, Meyer Zu Heringdorf D, Pfeilschifter J, Pfeilschifter W, Brunkhorst R. S1P d20:1, an endogenous modulator of S1P d18:1/S1P(2) -dependent signaling. FASEB J., 34(3): 3932-3942, 2020

2. Krämer M, Markart P, Drakopanagiotakis F, Mamazhakypov A, Schaefer L, Didiasova M, Wygrecka M. Pirfenidone inhibits motility of NSCLC cells by interfering with the urokinase system. Cell Signal. 65: 109432, 2020 

3. Meschede J, Šadić M, Furthmann N, Miedema T, Sehr DA, Müller-Rischart AK, Bader V, Berlemann LA, Pilsl A, Schlierf A, Barkovits K, Kachholz B, Rittinger K, Ikeda F, Marcus K, Schaefer L, Tatzelt J, Winklhofer KF. The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC. Sci Signal., 13(617), 2020

4. Roedig H, Damiescu R, Zeng-Brouwers J, Kutija I, Trebicka J, Wygrecka M, Schaefer L. Danger matrix molecules orchestrate CD14/CD44 signaling in cancer development. Semin Cancer Biol, 62: 31-47, 2020

5. Wygrecka M and Schaefer L. Between life and death: Epithelial cells in lung pathologies. Cell Signal 72: 109652, 2020

6. Rudloff I, Jarde T, Bachmann M, Elgass KD, Kerr G, Engel R, Richards E, Oliva K, Wilkins S, McMurrick PJ, Abud HE, Mühl H, Nold MF. Molecular signature of interleukin-22 in colon carcinoma cells and organoid models. Transl Res., 216: 1-22, 2020

7. Madhusudhan T, Ghosh S, Wang H, Wie D, Gupta D, Stoyanov S, Elwakiel A, Al-Dabet MM, Krishnan S, Kohli S, Biemann R, Nazir S, Zimmermann S, Mathew A, Gadi IUR, Rana R, Zeng-Brouwers J, Möller M, Schaefer L, Esmon C, Reiser J, Rezaie A, Ruf W, Isermann B. Integrin αvβ3 on podocytes orchestrates coagulation protease signaling through protease-activated receptors. J Am Soc Nephrol., 31(8): 1762-1780, 2020 

8. Zeng-Brouwers J, Pandey S, Trebicka J, Wygrecka M, Schaefer L. Communications via the small leucine-rich proteoglycans: Molecular specificity in inflammation and autoimmune diseases.  J Histochem Cytochem., 68(12): 887-906, 2020.

9. Schierwagen R, Uschner FE, Torres S, Ortiz C, Brol MJ, Tyc O, Gu W, Grimm C, Zeuzem S, Plamper A, Pfeifer P, Zimmer S, Welsch C, Schaefer L, Rheinwalt KP, Clària J, Arroyo V, Trebicka J, Klein S. The role of macrophage-inducible C-type lectin in different stages of chronic liver disease. Front Immunol., Jul 7;11:1352 2020

10. Schwarzkopf KM, Eberle L, Uschner FE, Klein S, Schierwagen R, Muecke MM, Schaefer L, Clària J, Zeuzem S, Hintermann E, Christen U, Lange CM, Trebicka J, Welsch C: Interleukin-22 (IL-22) in Acute-on-Chronic Liver Failure. A matter of ineffective levels, receptor dysregulation or defective signaling? J Hepatol., 73(4):980-982, 2020

11. Bachmann M, Lamprecht L, Gonther S, Pfeilschifter J, Mühl H. A murine cellular model of necroinflammation displays RAGE-dependent cytokine induction that connects to hepatoma cell injury. J Cell Mol Med., 24(18):10356-10366, 2020

12. Jakobi K, Beyer S, Koch A, Thomas D, Schwalm S, Zeuzem S, Pfeilschifter J, Grammatikos G. Sorafenib Treatment and Modulation of the Sphingolipid Pathway Affect Proliferation and Viability of Hepatocellular Carcinoma In Vitro. Int J Mol Sci., 21(7): 2409, 2020

13. Imre G. The involvement of regulated cell death forms in modulating the bacterial and viral pathogenesis. Int Rev Cell Mol Biol., 353: 211-253, 2020

14. Imre G. Cell death signalling in virus infection. Cell Signal, 76:109772, 2020

15. Umeshappa CS, Mbongue J, Singha S, Mohapatra S, Yamanouchi J, Lee JA, Nanjundappa RH, Shao K, Christen U, Yang Y, Ellestad KK, Santamaria P. Ubiquitous antigen-specific T regulatory type 1 cells variably suppress hepatic and extrahepatic autoimmunity. J Clin Invest., 130(4):1823-1829, 2020

16. Huhn M, Juan MHS, Melcher B, Dreis C, Schmidt KG, Schwiebs A, Collins J, Pfeilschifter JM, Vieth M, Stein J, Radeke HH. Inflammation-Induced Mucosal KYNU Expression Identifies Human Ileal Crohn's Disease. J Clin Med., 9(5): 1360, 2020

17. Faqar-Uz-Zaman WF, Schmidt KG, Thomas D, Pfeilschifter JM, Radeke HH, Schwiebs A. S1P Lyase siRNA Dampens Malignancy of DLD-1 Colorectal Cancer Cells. Lipids, Sep 24.doi: 10.1002/lipd.12282. Online ahead of print., 2020 (in press)

18. Christen U, Kimmel K. Chemokines as drivers of the autoimmune destruction in type 1 diabetes: Opportunity for therapeutic intervention in consideration of an optimal treatment schedule. Front Endocrinol., 11: 591083. doi: 10.3389/fendo.2020.591083. eCollection 2020.

19. Xia H, Li Z, Sharp TE 3rd, Polhemus DJ, Carnal J, Moles KH, Tao YX, Elrod J, Pfeilschifter J, Beck KF, Lefer DJ. Endothelial Cell Cystathionine γ-Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury. J Am Heart Assoc. 2020 Oct 20;9(19):e017544. doi: 10.1161/JAHA.120.017544. Epub 2020 Sep 29.

20. Stepanovska B, Lange AI, Schwalm S, Pfeilschifter J, Coldewey SM, Huwiler A. Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge. Int J Mol Sci., 21(4): 1240, 2020

21. Hiesinger K, Kramer JS, Beyer S, Eckes T, Brunst S, Flauaus C, Wittmann SK, Weizel L, Kaiser A, Kretschmer SBM, George S, Angioni C, Heering J, Geisslinger G, Schubert-Zsilavecz M, Schmidtko A, Pogoryelov D, Pfeilschifter J, Hofmann B, Steinhilber D, Schwalm S, Proschak E. Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase. J Med Chem. 63(20): 11498-11521, 2020

22. Schwalm S, Erhardt M, Römer I, Pfeilschifter J, Zangemeister-Wittke U, Huwiler A. Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt. Int J Mol Sci., 21(4): 1396, 2020

23. Mücke VT, Maria Schwarzkopf K, Thomas D, Mücke MM, Rüschenbaum S, Trebicka J, Pfeilschifter J, Zeuzem S, Lange CM, Grammatikos G. Serum Sphingosine-1-Phosphate Is Decreased in Patients With Acute-on-Chronic Liver Failure and Predicts Early Mortality. Hepatol Commun., 4(10): 1477-1486, 2020.

24. Lucaciu A, Brunkhorst R, Pfeilschifter JM, Pfeilschifter W, Subburayalu J. The S1P-S1PR Axis in Neurological Disorders-Insights into Current and Future Therapeutic Perspectives. Cells, 9(6): 1515, 2020

25. Christen U. Breakdown of tolerance in autoimmune hepatitis: This time toxin beats virus. Immunol Lett., 218. 51-53, 2020

26. Blankenbach KV, Claas RF, Aster NJ, Spohner AK, Trautmann S, Ferreirós N, Black JL, Tesmer JJG, Offermanns S, Wieland T, Meyer zu Heringdorf D. Dissecting G_q/11-mediated plasma membrane translocation of sphingosine kinase-1.  Cells 9(10): 2201, 2020

27. Blankenbach KV, Bruno G, Wondra E, Spohner AK, Aster NJ, Vienken H, Trautmann S, Ferreirós N, Wieland T, Bruni P, Meyer zu Heringdorf D. The WD40 repeat protein, WDR36, orchestrates sphingosine kinase-1 recruitment and phospholipase C-β activation by G_q-coupled receptors. Biochim Biophys Acta Mol Cell Biol Lipids, 1865: 158704, 2020

28. Hagen-Euteneuer N, Alam S, Rindsfuesser H, Meyer zu Heringdorf D, van Echten-Deckert G. S1P-lyase deficiency uncouples ganglioside formation - Potential contribution to tumorigenic capacity. Biochim Biophys Acta Mol Cell Biol Lipids, 1865: 158708, 2020

29. Schnieder J, Mamazhakypov A, Birnhuber A, Wilhelm J, Kwapiszewska G, Ruppert C, Markart P, Wujak L, Rubio K, Barreto G, Schaefer L, Wygrecka M. Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores. Matrix Biol. 88: 69-88, 2020.

30. Lenz M, Eichler A, Kruse P, Strehl A, Rodriguez-Rozada S, Goren I, Yogev N, Frank S, Waisman A, Deller T, Jung S, Maggio N, Vlachos A. Interleukin 10 Restores Lipopolysaccharide-Induced Alterations in Synaptic Plasticity Probed by Repetitive Magnetic Stimulation. Front Immunol., 2020 Dec 16;11:614509. doi: 10.3389/fimmu.2020.614509. eCollection 2020.

31. Eberhardt W, Haussler K, Nasrullah U, Pfeilschifter J. Multifaceted Roles of TRIM Proteins in Colorectal Carcinoma. Int J Mol Sci., 21(20): 7532. doi: 10.3390/ijms21207532, 2020

32. Lucaciu A, Kuhn H, Trautmann S, Ferreirós N, Steinmetz H, Pfeilschifter J, Brunkhorst R, Pfeilschifter W, Subburayalu J, Vutukuri R. A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke. Int J Mol Sci. 2020 Aug 28;21(17):6242. doi: 10.3390/ijms21176242. PMID: 32872326; PMCID: PMC7503682.

1. Zucker M, Wujak L, Gungl A, Didiasova M, Kosanovic D, Petrovic A, Klepetko W, Schermuly RT, Kwapiszewska G, Schaefer L, Wygrecka M. LRP1 promotes synthetic phenotype of pulmonary artery smooth muscle cells in pulmonary hypertension. Biochim Biophys Acta - Mol Basis Dis, 1865:1604-1616, 2019

2. Roedig H, Nastase MV, Frey H, Moreth K, Zeng-Brouwers J, Poluzzi C, Hsieh LTH, Brandts C, Fulda S, Wygrecka M, and Schaefer L. Biglycan is a new high-affinity ligand for CD14 in macrophages. Matrix Biol., 77, 4-22, 2019

3. Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LTH, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Muench C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L: Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis: Impact on renal ischemia/reperfusion injury.  Kidney Int., 95: 540-562, 2019

4. Christen U. Pathogen infection and autoimmune disease. Clin Exp Immunol., 195(1): 10-14, 2019

5. Christen U and Hintermann E. Pathogens and autoimmune hepatitis. Clin Exp Immunol., 195(1): 35-51, 2019

6. Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A. Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain. Cell, 176(6): 1407-1419, 2019

7. Fettel J, Kühn B, Guillen NA, Sürün D, Peters M, Bauer R, Angioni C, Geisslinger G, Schnütgen F, Meyer Zu Heringdorf D, Werz O, Meybohm P, Zacharowski K, Steinhilber D, Roos J, Maier TJ. Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity. FASEB J., 33(2): 1711-1726, 2019

8. Brunkhorst R, Pfeilschifter W, Rajkovic N, Pfeffer M, Fischer C, Korf HW, Christoffersen C, Trautmann S, Thomas D, Pfeilschifter J, Koch A. Diurnal regulation of sphingolipids in blood. Biochim Biophys Acta Mol Cell Biol Lipids, 1864(3): 304-311, 2019

9. Violatto MB, Casarin E, Talamini L, Russo L, Baldan S, Tondello C, Messmer M, Hintermann E, Rossi A, Passoni A, Bagnati R, Biffi S, Toffanin C, Gimondi S, Fumagalli S, De Simoni MG, Barisani D, Salmona M, Christen U, Invernizzi P, Bigini P, Morpurgo M. Dexamethasone Conjugation to Biodegradable Avidin-Nucleic-Acid-Nano-Assemblies Promotes Selective Liver Targeting and Improves Therapeutic Efficacy in an Autoimmune Hepatitis Murine Model. ACS Nano, 13(4): 4410-4423, 2019

10. Roedig H, Nastase MV, Wygrecka M, Schaefer L. Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy. FEBS J., 286(15): 2965-2979, 2019

11. Schwiebs A, Herrero San Juan M, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH. Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase. Oncogene, 38(24): 4788-4803, 2019

12. Goren I, Köhler Y, Aglan A, Pfeilschifter J, Beck KF, Frank S. Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes. Nitric Oxide, 87: 31-42, 2019

13. Büttner S, Koch A, Pfeilschifter J. Diuretic Therapy. Dtsch Med Wochenschr., 144(6): 387-392, German, 2019

14. Mamazhakypov A, Schermuly RT, Schaefer L, Wygrecka M. Lipids - two sides of the same coin in lung fibrosis. Cell Signal, 60: 65-80, 2019

15. Christen U. Animal models of autoimmune hepatitis. Biochim Biophys Acta- Mol Bases Dis, 1865(5): 970-981, 2019

16. Nejatian N, Trautmann S, Thomas D, Pfeilschifter J, Badenhoop K, Koch A, Penna-Martinez M. Vitamin D effects on sphingosine 1-phosphate signaling and metabolism in monocytes from type 2 diabetes patients and controls. J Steroid Biochem Mol Biol., 186: 130-135, 2019

17. Didiasova M, Schaefer L, Wygrecka M. When place matters: shuttling of enolase-1 across cellular compartments. Front Cell Dev Biol., 26;7:61. doi: 10.3389/fcell.2019.00061. eCollection 2019.

18. von Knethen A, Schäfer A, Kuchler L, Knape T, Christen U, Hintermann E, Fißlthaler B, Schröder K, Brandes RP, Genz B, Abshagen K, Pützer BM, Sha LK, Weigert A, Syed SN, Schulz M, Shah AM, Ernst A, Putyrski M, Finkelmeier F, Pesic  M, Greten F, Hogardt M, Kempf VAJ, Gunne S, Parnham MJ, Brüne B. Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis. Theranostics, 16;9(7): 2003-2016, 2019

19. Fuchs S, Bayer M, Taubert R, Manns MP, Pfeilschifter JM, Christen U, Hintermann E. Effects of adenovirus-induced hepatocyte damage on chronic bileduct inflammation in a sclerosing cholangitis mouse model. Liver Int. 2019 Jun 21. doi: 10.1111/liv.14183. [Epub ahead of print] PubMed PMID: 31225929.

20. Mücke VT, Thomas D, Mücke MM, Waidmann O, Zeuzem S, Sarrazin C, Pfeilschifter J, Vermehren J, Finkelmeier F, Grammatikos G. Serum sphingolipids predict de novo hepatocellular carcinoma in hepatitis C cirrhotic patients with sustained virologic response. Liver Int. 2019 Jun 17. doi: 10.1111/liv.14178. [Epub ahead of print] PubMed PMID: 31207039.

21. Patyna S, Büttner S, Eckes T, Obermüller N, Bartel C, Braner A, Trautmann S, Thomas D, Geiger H, Pfeilschifter J, Koch A. Blood ceramides as novel markers for renal impairment in systemic lupus erythematosus. Prostaglandins Other Lipid Mediat. 2019 Jul 10:106348. doi: 10.1016/j.prostaglandins.2019.106348. [Epub ahead of print] PubMed PMID: 31301404.

22. Eberhardt W, Nasrullah U and Haeussler K. Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells? Cells, 8, 797, 2019

23. Mühl H, Bachmann M. IL-18/IL-18BP and IL-22/IL-22BP:Two interrelated couples with therapeutic potential. Cell Signal., Aug 8:109388. doi: 10.1016/j.cellsig.2019.109388. [Epub ahead of print], 2019

24. Ghițu A, Schwiebs A, Radeke HH, Avram S, Zupko I, Bor A, Pavel IZ, DeheleanCA, Oprean C, Bojin F, Farcas C, Soica C, Duicu O, Danciu C. A ComprehensiveAssessment of Apigenin as an Antiproliferative, Proapoptotic, Antiangiogenic and Immunomodulatory Phytocompound. Nutrients, 16;11(4), 2019

25. Weigert A, von Knethen A, Thomas D, Faria I, Namgaladze D, Zezina E, Fuhrmann D, Petcherski A, Heringdorf DMZ, Radeke HH, Brüne B. Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation. Biochim Biophys Acta - Mol Cell Biol Lipids, 1864(9): 1235-1246, 2019

26. Danciu C, Pinzaru I, Coricovac D, Andrica F, Sizemore I, Dehelean C, Baderca F, Lazureanu V, Soica C, Mioc M, Radeke H. Betulin silver nanoparticles qualify as efficient antimelanoma agents in in vitro and in vivo studies. Eur J Pharm Biopharm., 134: 1-19, 2019

27. Dreis C, Ottenlinger FM, Putyrski M, Ernst A, Huhn M, Schmidt KG, Pfeilschifter JM, Radeke HH. Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T  Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs. Front Immunol., 10: 1698, 2019

28. Hewitt SM, Schaefer L. Renal Fibrosis: Common Enemy of Many Origins. J Histochem Cytochem., 67(9): 621, 2019

29. Nasrullah U, Haeussler K, Biyanee A, Wittig I, Pfeilschifter J, Eberhardt W. Identification of TRIM25 as a negative regulator of caspase-2 translation reveals a novel target for sensitizing colon carcinoma cells to intrinsic apoptosis. Cells, 2019, 8(12), 1622

30. Hintermann E, Christen U. The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis. Cells, 8(12). pii: E1503. doi: 10.3390/cells8121503, 2019

31. Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras DI, Randriamboavonjy V, Wittig J, Kojonazarov B, Schürmann C, Siragusa M, Siuda D, Luck B, Abdel Malik R, Filis KA, Zografos G, Chen C, Wang DW, Pfeilschifter J, Brandes RP, Szabo C, Papapetropoulos A, Fleming I. Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis.  Circulation, 139(1):101-114, 2019

32. Schiekirka-Schwake S, Barth J, Pfeilschifter J, Hickel R, Raupach T, Herrmann-Lingen C. National survey of evaluation practices and performance-guided resource allocation at German medical schools. Ger Med Sci., 17:Doc04. doi: 10.3205/000270. eCollection 2019.

1. Nastase MV, Janicova A, Roedig H, Hsieh LTH, Wygrecka M, and Schaefer L. Small leucine-rich proteoglycans in renal inflammation: two sides of the coin. J Histochem Cytochem, 66(4): 261-272, 2018

2. Frevert CW, Felgenhauer J, Wygrecka M, Nastase MV, and Schaefer L. Danger associated molecular patterns from the extracellular matrix provide temporal control of innate immunity. J Histochem Cytochem, 66(4): 213–227, 2018

3. Wujak L, Böttcher R, Pak O, Frey H, El Agha E, Chen Y, Schmitt S, Bellusci S, Schaefer L, Weissmann N, Fässler R, and Wygrecka M. Low Density Lipoprotein Receptor-related Protein 1 Couples β1 Integrin Activation to Degradation.Cell Mol Life Sci, 75: 1671-1685, 2018

4. Hermann A, Wennmann DO, Gromnitza S, Edeling M, van Marck V, Sudol M, Schaefer L, Duning K, Weide T, Pavenstädt H, and Kremerskother J. WW and C2 domain-containing proteins regulate hepatic cell differentiation and tumorigenesis through the hippo signaling pathway. Hepatology, 67(4): 1546-1559, 2018

5. Hardt S, Valek L, Zeng-Brouwers J, Wilken-Schmitz A, Schaefer L, and Tegeder I. Nephrogenic diabetes insipidus in aged progranulin deficient mice. Aging Dis. 9(5): 817-830, 2018

6. Vutukuri R, Brunkhorst R, Kestner RI, Hansen L, Ferreiros Bouzas N, Pfeilschifter J, Devraj K, and Pfeilschifter W.Alteration of sphingolipid metabolism as a putative mechanism underlying LPS-induced BBB disruption. J Neurochem., 144(2): 172-185, 2018

7. Schwiebs A and Radeke H. Immunopharmacological activity of betulin in inflammation-associated carcinogenesis. Anticancer Agents Med Chem. 18(5): 645-651, 2018

8. Wujak L, Schnieder J, Schaefer L, and Wygrecka M. LRP1: a chameleon receptor of lung inflammation and repair.Matrix Biol., 68-69: 366-381, 2018

9. Imre G and Rajalingam K. Apoptosis Inhibitor 5: Role in the inhibition of caspase-2. Cell Cycle. 17(4): 397-398, 2018

10. Nastase MV, Zeng-Brouwers J, Wygrecka M, and Schaefer L. Targeting renal fibrosis: mechanisms and drug delivery systems. Adv Drug Deliv Rev, 129: 295-307, 2018

11. Eresch J, Stumpf M, Koch A, Vutukuri R, Ferreirós N, Schreiber Y, Schröder K, Devraj K, Popp R, Hattenbach LO, Pfeilschifter J, and Pfeilschifter W. Sphingosine kinase 2 modulates retinal neovascularization Invest Ophthalmol Vis Sci., 59(2): 653-661, 2018

12. Bachmann M, Pfeilschifter J, and Mühl H. A prominent role of IL-18 in acetaminophen-induced liver injury advocates its blockage for therapy of hepatic necroinflammation. Front Immunol, 9: 161. doi: 10.3389/fimmu.2018.00161. eCollection 2018

13. Goren I, Christen U, Pfeilschifter J, and Stefan Frank. A heterogeneous Ly-6B2+ leukocyte population consists of yet undescribed iNOS-expressing cell types in murine skin wounds. Nitric Oxide, 74:23-31, 2018

14. Nastase MV, Zeng-Brouwers J, Beckmann J, Tredup C, Christen U, Radeke HH, Wygrecka M, and Schaefer L.Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney. Matrix Biol 68-69: 293-317, 2018

15. Bachmann M, Pfeilschifter J, and Mühl H. Epigenetic regulation by CpG methylation splits strong from retarded IFNγ-induced IL-18BP in epithelial versus monocytic cells. BBA-GENE REGUL MECH, 1861(3): 191-199, 2018

16. Zakrzewicz D, Didiasova M, Krüger M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Zakrzewicz A, Schaefer L, Preissner KT, and Wygrecka M. Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells. Biochim Biophys Acta - Molecular Basis of Disease, 1864(5 Pt A): 1816-1827, 2018

17. Wagner J, Chavakis E, Rogg E-M, Muhly-Reinholz M, Glaser SF, Guenther S, John D, Bonini F, Zeiher A, Schaefer L, Hannocks M-J, Boon RA, and Dimmeler S. A switch in laminin β2 to laminin β1 isoforms during aging enhances endothelial-mesenchymal transition. Arterioscler Thromb Vasc Biol., 38: 1170-1177, 2018

18. Badawi A, Biyanee A, Nasrullah U, Winslow S, Schmid T, Pfeilschifter J, and Eberhardt W. Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells. Oncotarget, 9(26): 18367-18385, 2018

19. Didiasova M, Schaefer L, and Wygrecka M. Targeting GLI transcription factors in cancer.  Molecules, 23(5). pii: E1003. doi: 10.3390/molecules23051003, 2018

20. Schaefer L. Decoding fibrosis: Mechanisms and translational aspects. Matrix Biol 68-69: 1-7, 2018

21. Brunkhorst R, Pfeilschifter W, Patyna S, Büttner S, Eckes T, Trautmann S, Thomas D, Pfeilschifter J, and Koch A.Preanalytical Biases in the Measurement of Human Blood Sphingolipids. Int J Mol Sci., 19(5), 2018

22. Patyna S, Eckes T, Büttner S, Pfeilschifter J, and Koch A. Sphingosine 1-phosphate in renal diseases: Molecular mechanisms and clinical relevance. Nieren- und Hochdruckkrankheiten, Jahrgang 47, März (137-141), 2018

23. Huwiler A and Pfeilschifter J. Sphingolipid signaling in renal fibrosis. Matrix Biol., 68-69, 230-247, 2018

24. Christen U, Hintermann E. Autoantibodies in Autoimmune Hepatitis: Can Epitopes Tell Us about the Etiology of the Disease? Front Immunol. 2018 Feb 16;9:163. doi: 10.3389/fimmu.2018.00163. eCollection 2018. Review.

25. Hintermann E, Bayer M, Conti CB, Fuchs S, Fausther M, Leung PS, Aurrand-Lions M, Taubert R, Pfeilschifter JM, Friedrich-Rust M, Schuppan D, Dranoff JA, Gershwin ME, Manns MP, Imhof BA, and Christen U. Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice. J Autoimmun., 91: 83-96, 2018

26. Kwapiszewska G, Gungl A, Wilhelm J, Marsh L, Thekkekara Puthenparampil H, Sinn K, Didiasova M, Klepetko W, Kosanovic D, Schermuly RT, Wujak L, Weiss B, Schaefer L, Schneider M, Kreuter M, Olschewski A, Seeger W, Olschewski H, and Wygrecka M. Transcriptome profiling reveals the complexity of pirfenidone effects in IPF.  Eur Respir J, 52(5). pii: 1800564. doi: 10.1183/13993003.00564-2018, 2018

27. Rogg EM, Abplanalp WT, Bischof C, John D, Schulz MH, Krishnan J, Fischer A, Poluzzi C, Schaefer L, Bonauer A, Zeiher AM, and Dimmeler S. Analysis of cell type-specific effects of miR-92a provides novel insights into target regulation and mechanism of action. Circulation, 138:2545-2558, 2018

28. Didiasova M, Wujak M, Schaefer L, Wygrecka M: Cellular effects of coagulation factor XII. Cell Signal, 51: 257-265. 2018

29. Beyer S, Schwalm S, Pfeilschifter J, and Huwiler A. Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis. Cell Physiol Biochem., 47: 2522-2533, 2018

30. Eberhardt W, Nasrullah U, and Pfeilschifter J. Activation of renal profibrotic TGFbeta controlled signaling cascades by calcineurin and mTOR inhibitors. Cell Signal, 52: 1-11, 2018

31. Luger S, Schwebler A, Vutukuri R, Bouzas NF, Labocha S, Schreiber Y, Brunkhorst R, Steinmetz H, Pfeilschifter J, Pfeilschifter W. Beta adrenoceptor blockade ameliorates impaired glucose tolerance and alterations of the cerebral ceramide metabolism in an experimental model of ischemic stroke. Ther Adv Neurol Disord., 2018 Apr 19;11:1756286418769830. doi: 10.1177/1756286418769830. eCollection 2018

32. Danciu C, Zupko I, Bor A, Schwiebs A, Radeke H, Hancianu M, Cioanca O, Alexa E, Oprean C, Bojin F, Soica C, Paunescu V, and Dehelean CA. Botanical Therapeutics: Phytochemical Screening and Biological Assessment of Chamomile, Parsley and Celery Extracts against A375 Human Melanoma and Dendritic Cells. Int J Mol Sci., 19(11). pii: E3624, 2018

33. Blanchard O, Stepanovska B, Starck M, Erhardt M, Römer I, Meyer Zu Heringdorf D, Pfeilschifter J, Zangemeister-Wittke U, Huwiler A. Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells. Int J Mol Sci., 19(5). pii: E1498, 2018

34. Bruno G, Cencetti F, Bernacchioni C, Donati C, Blankenbach KV, Thomas D, Meyer Zu Heringdorf D, Bruni P. Bradykinin mediates myogenic differentiation in murine myoblasts through the involvement of SK1/Spns2/S1P(2) axis. Cell Signal., 45: 110-121, 2018

35. Josipovic I, Pflüger B, Fork C, Vasconez AE, Oo JA, Hitzel J, Seredinski S, Gamen E, Heringdorf DMZ, Chen W, Looso M, Pullamsetti SS, Brandes RP, Leisegang MS. Long noncoding RNA LISPR1 is required for S1P signaling and endothelial cell  function. J Mol Cell Cardiol., 116: 57-68, 2018

36. Pleli T, Mondorf A, Ferreiros N, Thomas D, Dvorak K, Biondi RM, Heringdorf DMZ, Zeuzem S, Geisslinger G, Zimmermann H, Waidmann O, Piiper A. Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors. Cell Physiol Biochem., 45(6): 2516-2528, 2018

37. Zezina E, Snodgrass RG, Schreiber Y, Zukunft S, Schürmann C, Heringdorf DMZ, Geisslinger G, Fleming I, Brandes RP, Brüne B, Namgaladze D. Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses. Biochim Biophys Acta Mol Cell Biol Lipids., 1863(4): 433-446, 2018

38. Moll F, Walter M, Rezende F, Helfinger V, Vasconez E, De Oliveira T, Greten FR, Olesch C, Weigert A, Radeke HH, Schröder K. NoxO1 Controls Proliferation of Colon Epithelial Cells. Front Immunol., 9:973. doi: 10.3389/fimmu.2018.00973. eCollection 2018, 2018 

1. Goren I, Lee SY, Maucher D, Nüsing R, Schlich T, Pfeilschifter J, and Frank S. Inhibition of cyclooxygenase-1 and -2 activity in keratinocytes inhibits PGE2 formation and impairs VEGF release and neovascularization in skin wounds.Int Wound J., 14: 53-63, 2017

2. Frey H, Moreth K, Hsieh LTH, Zeng-Brouwers J, Rathkolb B, Fuchs H, Gailus-Durner V, Iozzo RV, Hrabě de Angelis M, and Schaefer L. A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia. Glycoconj J., 34(3): 393-404, 2017

3. Schaefer L, Tredup C, Gubbiotti M, and Iozzo RV. Proteoglycan neofunctions: Regulation of inflammation and autophagy in cancer biology. FEBS J 284: 10-26, 2017

4. Bender C, Christen S, Scholich K, Bayer M, Pfeilschifter JM, Hintermann E, and Christen U. Islet-expressed CXCL10 Promotes Autoimmune Destruction of Islet Iso-Grafts in Mice with Type 1 Diabetes. Diabetes. 66(1): 113-126, 2017

5. Didiasova M, Singh R, Kwapiszewska G, Wujak L, Zakrzewicz D, Markart P, Seeger W, Schaefer L, Lauth M, and Wygrecka M. Pirfenidone exerts anti-fibrotic effects through a direct inhibition of GLI transcription factors. FASEB J 31: 1916-1928, 2017

6. Martin J, Radeke HH, Dignass A and Stein J. Curent evaluation and management of anaemia in patients with inflammatory bowel disease. Expert Rev Gastroenterol Hepatol., 11(1): 19-32, 2017

7. Wygrecka M, Kosanovic D, Zakrzewicz D, Hess R, Henneke I, Didiasova M, Wujak L, Baal N, Hackstein H, Reppe K, Müller-Redetzky HC, Witzenrath M, de Maat S, Maas C, Nolte MV, Panousis C, Ralph T. Schermuly RT, Schaefer L, and Markart P. C1 esterase inhibitor protects against histone-mediated lung injury. Am J Respir Crit Care Med., 196: 186-199, 2017

8. Friedländer F, Bohmann F, Brunkhorst M, Chae JH, Devraj K, Köhler Y, Kraft P, Kuhn H, Lucaciu A, Luger S, Pfeilschifter W, Sadler R, Liesz A, Scholtyschik K, Stolz L, Vutukuri R, and Brunkhorst R. Reliability of infarct volumetry: Its relevance and the improvement by a software-assisted approach. J Cereb Blood Flow Metab., 37(8): 3015-3026, 2017

9. Frölich S, Slattery P, Thomas D, Goren I, Ferreiros N, Jensen BL, and Nüsing RM. Angiotensin II-AT1-receptor signaling is necessary for cyclooxygenase-2-dependent postnatal nephron generation. Kidney Int., 91: 818-829, 2017

10. Bachmann M, Meissner C, Pfeilschifter J, and Mühl, H. Cooperation between the bacterial-derived short-chain fatty acid butyrate and interleukin-22 detected in human Caco2 colon epithelial/carcinoma cells. Biofactors, 43(2): 283-292, 2017

11. Badawi A, Hehlgans S, Pfeilschifter J, Rödel F and Eberhardt W. Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2. Cancer Lett., 393: 103-112, 2017

12. Ball AK, Beilstein K, Wittmann S, Sürün D, Saul M, Schnütgen F, Flamand N, Capelo R, Kahnt AS, Frey H, Schaefer L, Marschalek R, Häfner AK, Steinhilber S. Characterization and cellular localization of human 5lipoxygenase and its protein isoforms 5-LOΔ13, 5-LOΔ4 and 5-LOp12. Biochim Biophys Acta 1862: 561-571, 2017

13. Slattery P, Frölich S, Goren I, and Rolf Nüsing. Salt supplementation ameliorates developmental kidney defects in COX-2-/- mice. American Journal of Physiology - Renal Physiology, 312(6):F1044-F1055, 2017

14. Hsieh LTH, Nastase MV, Roedig H, Zeng-Brouwers J, Poluzzi C, Schwalm S, Fork C, Tredup C, Brandes RP, Wygrecka M, Huwiler A, Pfeilschifter J, and Schaefer L. Biglycan- and sphingosine kinase1-signaling crosstalk regulates the synthesis of macrophage chemoattractants. Int J Mol Sci , 18, 595; doi:10.3390/ijms18030595, 2017

15. Imre G, Berthelet J, Heering J, Kehrloesser S, Melzer IM, Lee BI, Thiede B, Dötsch V, and Rajalingam K. Apoptosis inhibitor 5 is an endogenous inhibitor of caspase-2. EMBO Rep., 18(5):733-744, 2017

16. Nastase MV, Janicova A, Wygrecka M, and Schaefer L. Signaling at the crossroads: Matrix-derived proteoglycan- and reactive oxygen species signaling. Antioxid Redox Signal, 27: 855-873, 2017

17. Wujak L, Hesse C, Sewald K, Jonigk D, Braubach P, Warnecke G, Fieguth HG, Braun A, Lochnit G, Markart P, Schaefer L, and Wygrecka M. FXII promotes proteolytic processing of the LRP1 ectodomain. Biochim Biophys Acta Gen Subject 1861: 2088-2098, 2017

18. Chichelnitskiy E, Himmelseher B, Bachmann M, Pfeilschifter J, and Mühl H. Hypothermia promotes IL-22 expression and fine-tunes its biological activity. Front Immunol.8: 742, 2017

19. Bachmann M, Waibler Z, Pleli T, Pfeilschifter J and Mühl H. Type I interferon supports inducible nitric oxide synthase in murine hepatoma cells and hepatocytes and during experimental acetaminophen-induced liver damage. Front Immunol. 2017 Jul 31;8:890. doi: 10.3389/fimmu.2017.00890. eCollection 2017.

20. Koch A, Grammatikos G, Trautmann S, Schreiber Y, Thomas D, Bruns F, Pfeilschifter J, Badenhoop K, and Penna-Martinez M. Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. Int J Mol Sci. 18(7), pii: E1532. doi: 10.3390/ijms18071532. PubMed PMID: 28714882, 2017

21. Hinrichsen I, Weßbecher IM, Huhn M, Passmann S, Zeuzem S, Plotz G, Biondi RM, and Brieger A. Phosphorylation-dependent signaling controls degradation of DNA mismatch repair protein PMS2. Mol Carcinog., 56(12): 2663-2668, 2017

22. Hess R, Wujak L, Hesse C, Sewald K, Jonigk D, Warnecke G, Fieguth H-G, de Maat S, Maas C, Bonella F, Preissner KT, Weiss B, Schaefer L, Kuebler W, Markart P, and Wygrecka M. Coagulation factor XII regulates inflammatory responses in human lungs. Thromb Haemost., 117(10): 1896-1907, 2017

23. Schwalm S, Beyer S, Frey H, Haceni R, Grammatikos G, Thomas D, Geisslinger G, Schaefer L, Huwiler A, and Pfeilschifter J. Sphingosine kinase-2 deficiency ameliorates kidney fibrosis by up-regulating Smad7 in a mouse model of unilateral ureteral obstruction.Am J Pathol, 187: 2413-2429, 2017

24. Vienken H, Mabrouki N, Grabau K, Claas RF, Rudowski A, Schömel N, Pfeilschifter J, Lütjohann D, van Echten-Deckert G, and Meyer Zu Heringdorf D. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca(2+) storage. Sci Rep., 7: 43575. doi: 10.1038/srep43575, 2017

25. Richter C, Herrero San Juan M, Weigmann B, Bergis D, Dauber K, Muders MH, Baretton GB, Pfeilschifter JM, Bonig H, Brenner S, and Radeke HH. Defective IL-23/IL-17 Axis Protects p47phox-/- Mice from Colon Cancer. Front Immunol., 8:44. doi: 10.3389/fimmu.2017.00044. eCollection 2017, 2017

26. Aglan A, Longen S, Dehne N, Köhler Y, Hassan M, Beck M, Tredup C, Boosen M, Hsieh TL, Schaefer L, Beck KF, and Pfeilschifter J. Nitric oxide mediates prolyl hydroxylase 3 expression in mesangial cells and in glomerulonephritis. J Mol Med (Berl)., 95(3):257-271, 2017

27. Bonvin P, Gueneau F, Buatois V, Charreton-Galby M, Lasch S, Messmer M, Christen U, Luster AD, Johnson Z, Ferlin W, Kosco-Vilbois M, Proudfoot A, and Fischer N. Antibody Neutralization of CXCL10 in Vivo Is Dependent on Binding to Free and Not Endothelial-bound Chemokine: IMPLICATIONS FOR THE DESIGN OF A NEW GENERATION OF ANTI-CHEMOKINE THERAPEUTIC ANTIBODIES. J Biol Chem., 10; 292(10): 4185-4197, 2017

28. Honke N, Shaabani N, Teijaro JR, Christen U, Hardt C, Bezgovsek J, Lang PA, and Lang KS. Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8(+) T Cells. Front Immunol., 8: 113. doi: 10.3389/fimmu.2017.00113. eCollection 2017, 2017

29. Oertel S, Scholich K, Weigert A, Thomas D, Schmetzer J, Trautmann S, Wegner MS, Radeke HH, Filmann N, Brüne B, Geisslinger G, Tegeder I, and Grösch S. Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cell Mol Life Sci., 74(16): 3039-3055, 2017

30. Schmidt K, Herrero San Juan M, Trautmann S, Berninger L, Schwiebs A, Ottenlinger F, Thomas D, Zaucke F, Pfeilschifter JM, and Radeke HH. Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study.Front Immunol. 2017 Sep 29;8:1242. doi: 10.3389/fimmu.2017.01242. eCollection 2017.

31. Stein J, Aksan A, Farrag K, Dignass A, and Radeke HH. Management of inflammatory bowel disease-related anemia and iron deficiency with specific reference to the role of intravenous iron in current practice. Expert Opin Pharmacother., 18(16): 1721-1737, 2017

32. Aksan A, Işık H, Radeke HH, Dignass A, and Stein J. Letter: the importance of dosing and baseline haemoglobin when establishing the relative efficacy of intravenous iron therapies-authors' reply. Aliment Pharmacol Ther., 46(7): 705-706, 2017

33. Aksan A, Işık H, Radeke HH, Dignass A, and Stein J. Letter: inconsistency in reporting of hypophosphataemia after intravenous iron-authors' reply. Aliment Pharmacol Ther., 46(6): 643-644, 2017

34. Aksan A, Işık H, Radeke HH, Dignass A, and Stein J. Editorial: which iron preparation for patients with IBD? Authors' reply. Aliment Pharmacol Ther., 46(2): 195-196, 2017

35. Aksan A, Işık H, Radeke HH, Dignass A, and Stein J. Systematic review with network meta-analysis: comparative efficacy and tolerability of different intravenous iron formulations for the treatment of iron deficiency anaemia in patients with inflammatory bowel disease. Aliment Pharmacol Ther., 45(10): 1303-1318, 2017

36. Schwiebs A, Thomas D, Kleuser B, Pfeilschifter JM, and Radeke HH. Nuclear Translocation of SGPP-1 and Decrease of SGPL-1 Activity Contribute to Sphingolipid Rheostat Regulation of Inflammatory Dendritic Cells. Mediaters Inflamm., 2017:5187368. doi: 10.1155/2017/5187368. Epub 2017 Dec 11, 2017

1. Poluzzi C, Iozzo RV, and Schaefer L. Endostatin and endorepellin: a common route of action for similar angiostatic cancer avengers. Adv Drug Deliv Rev 97: 156-173, 2016.

2. Neill T, Schaefer L, and Iozzo RV. Decorin as a multivalent therapeutic agent against cancer. Adv Drug Deliv Rev 97: 174-185, 2016.

3. Hsieh LT, Frey H, Nastase MV, Tredup C, Hoffmann A, Poluzzi C, Zeng-Brouwers J, Manon-Jensen T, Schröder K, Brandes RP, Iozzo RV, and Schaefer L. Bimodal role of NADPH Oxidases in the regulation of biglycan-triggered IL-1β synthesis. Matrix Biol 49: 61-81, 2016

4. Berner A, Bachmann M, Bender C, Pfeilschifter J, Christen U and Mühl H. Though Active on RINm5F Insulinoma Cells and Cultured Pancreatic Islets, Recombinant IL-22 Fails to Modulate Cytotoxicity and Disease in a Protocol of Streptozotocin-Induced Experimental Diabetes. Front Pharmacol., 6: 317, 2016

5. Ottenlinger F, Schwiebs A, Pfarr K, Wagner A, Grüner S, Mayer C, Pfeilschifter JM, Radeke HH. Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-γ production in CD8(+) lymphocytes. Eur J Immunol., 46(4): 941-951, 2016.

6. Shaabani N, Khairnar V, Duhan V, Zhou F, Tur RF, Häussinger D, Recher M, Tumanov AV, Hardt C, Pinschewer D, Christen U, Lang PA, Honke N, and Lang KS. Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation. J Autoimmun., 67: 82-89, 2016.

7. Bergis D, Kassis V, and Radeke HH. High plasma sST2 levels in gastric cancer and their association with metastatic disease. Cancer Biomarkers 16: 117–125, 2016

8. Klionsky DJ, …. Schaefer, L,…. and Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12: 1-222, 2016.

9. Schaefer L and Reinhardt DP Extracellular matrix: Therapeutic tools and targets in cancer treatment. Adv Drug Deliv Rev 97: 1-3, 2016

10. Grandoch M, Kohlmorgen C, Melchior-Becker A, Feldmann K, Homann S, Müller J, Kiene LS, Zeng-Brouwers J, Schmitz F, Nagy N, Polzin A, Gowert NS, Elvers M, Skroblin P, Yin X, Mayr M, Schaefer L, Tannock L, and Fischer JW. Loss of biglycan enhances thrombin generation in ApoE-deficient mice: Implications for inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol 36: e41-50, 2016

11. Mühl, H. STAT3, a key parameter of cytokine-driven tissue protection during sterile inflammation – the case of experimental acetaminophen (paracetamol)-induced liver damage. Front Immunol. 7: 163, 2016

12. Nastase MV, Zeng-Brouwers J, Frey H, Hsieh LT, Poluzzi C, Beckmann J, Schroeder N, Pfeilschifter J, Lopez-Mosqueda J, Mersmann J, Ikeda F, Iozzo RV, Dikic I, and Schaefer L. An essential role for SHARPIN in the regulation of caspase 1 activity in sepsis. Am J Pathol 186: 1206-1220, 2016

13. Schmidt F, Müller M, Prox J, Arnold P, Schönherr C, Tredup C, Minder P, Ebsen H, Janssen O, Annaert W, Pietrzik C, Schmidt-Arras D, Sterchi EE, and Becker-Pauly C. Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains. Biol Chem., 397(9): 857-869, 2016

14. Coldewey SM, Benetti E, Collino M, Pfeilschifter J, Sponholz C, Bauer M, Huwiler A, and Thiemermann C. Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis.Sci Rep. 6:27594, 2016

15. Grammatikos G, Schoell N, Ferreirós N, Bon D, Herrmann E, Farnik H, Köberle V, Piiper A, Zeuzem S, Kronenberger B, Waidmann O, and Pfeilschifter J. Serum sphingolipidomic analyses reveal an upregulation of C16- ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. Oncotarget, 7(14): 18095-18105, 2016

16. Grammatikos G, Dietz J, Ferreiros N, Koch A, Dultz G, Bon D, Karakasiliotis I, Lutz T, Knecht G, Gute P, Herrmann E, Zeuzem S, Mavromara, Sarrazin C, and Pfeilschifter J. Persistence of HCV in acutely-infected patients depletes C24-ceramide and upregulates sphingosine and sphinganine serum levels. Int J Mol Sci, 17: 922, 2016

17. Barallobre-Barreiro J, Gupta S, Zoccaratto A, Fava M, Yin X, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah A, Jahangiri M, Schaefer L, Fischer J, Iozzo RV, Viner R, Kichler A, Thum T, Heineke J, and Mayr M. Glypoproteomix reveals decorin fragments with anti-myostatin activity in human atrial fibrillation. Circulation, 134: 817-832, 2016

18. Imeri F, Schwalm S, Lyck R, Zivkovic A, Stark H, Engelhardt B, Pfeilschifter J, and Huwiler A. Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments. Neuropharmacology, 105: 341-350, 2016

19. Müller P, Messmer M, Bayer M, Pfeilschifter JM, Hintermann E, and Christen U. Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model. J Autoimmun., 69: 51-58, 2016

20. Hintermann E, Bayer M, Ehser J, Aurrand-Lions M, Pfeilschifter JM, Imhof BA, and Christen U. Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial and stellate cell interactions during hepatic fibrosis. Cell Adh Migr., 10(4): 419-433, 2016

21. Schwiebs A, Friesen O, Katzy E, Ferreirós N, Pfeilschifter JM, and Radeke HH. Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1. Front Pharmacol., 7: 94, 2016

22. Longen S, Richter F, Köhler Y, Wittig I, Beck KF, and Pfeilschifter J. Quantitative Persulfide Site Identification (qPerS-SID) Reveals Protein Targets of H2S Releasing Donors in Mammalian Cells. Sci Rep., 6: 29808, 2016

23. Blankenbach KV, Schwalm S, Pfeilschifter J, and Meyer Zu Heringdorf D. Sphingosine-1-Phosphate Receptor-2 Antagonists: Therapeutic Potential and Potential Risks. Front Pharmacol., 7: 167, 2016

24. Longen S, Beck KF, and Pfeilschifter J. H2S-induced thiol-based redox switches: Biochemistry and functional relevance for inflammatory diseases. Pharmacol Res., 111: 642-651, 2016

25. Eberhardt W, Badawi A, Biyanee A, and Pfeilschifter J. Cytoskeleton-Dependent Transport as a Potential Target for Interfering with Post-transcriptional HuR mRNA Regulons. Front Pharmacol., 7: 251, 2016.

26. Filipenko I, Schwalm S, Reali L, Pfeilschifter J, Fabbro D, Huwiler A, and Zangemeister-Wittke U. Upregulation of the S1P(3) receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE(2) and EP(2)/EP(4) activation. Biochim Biophys Acta., 1861(11): 1840-1851, 2016

27. Ottenlinger F, Mayer CA, Ferreirós N, Schreiber Y, Schwiebs A, Schmidt A, Ackermann H, Pfeilschifter J, and Radeke HH. Interferon-beta increases plasma ceramides of specific chain length in multiple sclerosis patients, unlike fingolimod or natalizumab. Front Pharmacol., 7: 412, 2016

28. Beetz N, Rommel C, Schnick T, Neumann E, Preissl S, Gilsbach R, Melchior-Becker A, Monroy-Ordonez E-B, Rylski B, Stoll M, Schaefer L, Beyersdorf F, Stiller B, and Hein L. Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload. J Mol Cell Cardiol 101:145-155, 2016

29. Wangorsch A, Larsson H, Messmer M, García-Moral A, Lauer I, Wolfheimer S, Schülke S, Bartra J, Vieths S, Lidholm J, Scheurer S. Molecular cloning of plane pollen allergen Pla a 3 and its utility as diagnostic marker for peach associated plane pollen allergy. Clin Exp Allergy, 46(5): 764-774, 2016

30. Zakrzewicz D, Bergmann S, Didiasova M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Lochnit G, Schaefer L, Hammerschmidt S, Preissner KT, and Wygrecka M. Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells. Sci Rep 6:37758

31. Neill T, Buraschi S, Goyal A, Sharpe C, Natkanski E, Schaefer L, Morrione A, and Iozzo RV. EphA2 is a functional receptor for progranulin. J Cell Biol, 215: 687-703, 2016

32. Christen U and Hintermann E. Immunopathogenic mechanisms of autoimmune hepatitis: How much do we know from animal models? Int J Mol Sci., 17(12), pii: E2007, 2016

33. Zschiebsch K, Fischer C, Pickert G, Häussler A, Radeke H, Grösch S, Ferreirós N, Geisslinger G, Werner ER, and Tegeder I. Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling. J Crohns Colitis, 10(8): 965-78, 2016

34. Siebert A, Goren I, Pfeilschifter J and Frank F. Anti-inflammatory effects of rosiglitazone in obesity-impaired wound healing depend on adipocyte differentiation. Plos One, 11(12): e0168562, 2016

35. Heim K, Dälken B, Faust S, Rharbaoui F, Engling A, Wallmeier H, Dingermann T, Radeke HH, Schüttrumpf J, and Gutscher M.High thioredoxin-1 levels in rheumatoid arthritis patients diminish binding and signalling of the monoclonal antibody Tregalizumab.Clin Transl Immunology., 5(12): e121. doi: 10.1038/cti.2016.69. eCollection 2016, 2016

1. Beck KF, Euler J, Eisel F , Beck M, Köhler Y, Sha LK, von Knethen A, Longen S, and Pfeilschifter J. Cytokines induce protein kinase A-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells. Biochem Pharmacol., 93(3): 362-9, 2015

    

2. Hintermann E, Bayer M, Pfeilschifter JM, Deak F, Kiss I, Paulsson M, and Christen U. Upregulation of matrilin-2 expression in murine hepatic stellate cells during liver injury has no effect on fibrosis formation and resolution. Liver Int., 35(4): 1265-73, 2015

    

3. Neil T, Schaefer L, and Iozzo RV Decoding the matrix: Instructive roles of proteoglycan receptors Biochemistry, 54(30): 4583-98, 2015

4. Doller A, Badawi A, Schmid T, Brauß T, Pleli T , Meyer zu Heringdorf D, Piiper A, Pfeilschifter J, and Eberhardt W.The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking. Exp Cell Res., 1;330(1):66-80, 2015

5. Fuchs S, Hsieh LT, Saarberg W, Erdelmeier CAJ, Schaefer L, Koch E, and Fürst R. Haemanthus coccineus extract and its main bioactive component narciclasine display profound anti-inflammatory activities in vitro and in vivo. J Cell Mol Med, 19: 1021-32, 2015

6. Neill T, Schaefer L, and Iozzo RV. Oncosuppressive functions of decorin. Mol Cell Oncol, 2(3):e975645, doi: 10.4161/23723556.2014.975645. eCollection 2015 Jul-Sep. Review. PubMed PMID: 27308453; PubMed Central PMCID: PMC4905288. 2015

7. Ihlefeld K, Vienken H, Claas RF, Blankenbach K, Rudowski A, Ter Braak M, Koch A, Van Veldhoven PP, Pfeilschifter J, and Meyer Zu Heringdorf D. Upregulation of ABC transporters contributes to chemoresistance of sphingosine-1-phosphate lyase-deficient fibroblasts.J Lipid Res., 56(1): 60-69, 2015

8. Helling B, König M, Dälken B, Engling A, Krömer W, Heim K, Wallmeier H, HaasJ, Wildemann B, Fritz B, Jonuleit H, Kubach J, Dingermann T, Radeke HH, OsterrothF, Uherek C, Czeloth N, and Schüttrumpf J. A specific CD4 epitope bound bytregalizumab mediates activation of regulatory T cells by a unique signalingpathway. Immunol Cell Biol., 93(4): 396-405, 2015

9. Grammatikos G, Ferreiros N, Bon D, Schwalm S, Dietz J, Berkowski C, Fitting D, Herrmann E, Zeuzem S, Sarrazin C, and Pfeilschifter J. Variations in serum sphingolipid levels associate with liver fibrosis progression and poor treatment outcome in HCV but not HBV infection. Hepatology. 61(3): 812-22, 2015

10. Biyanee A, Ohnheiser J, Singh P, and Klempnauer KH. A novel mechanism for the control of translation of specific mRNAs by tumor suppressor protein Pdcd4: inhibition of translation elongation. Oncogene, 34(11): 1384-92, 2015

11. Wünsche C, Koch A, Goldschmeding R, Schwalm S, Meyer zu Heringdorf D, Huwiler A, and Pfeilschifter J. Transforming growth factor beta2 (TGF-beta2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells. BBA - Molecular and Cell Biology of Lipids, 1851(5), 519-526, 2015

12. Wujak L, Didiasova M, Frey H, Schaefer L, and Wygrecka M. Heparan sulfate proteoglycans mediate Factor XIIa binding to the cell surface. J Biol Chem, 290(11): 7027-39, 2015

13. Scheiermann P, Bachmann M, Härdle L, Pleli T, Piiper A, Zwissler B, Pfeilschifter J, and Mühl, H. Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury. Sci Rep., 5: 8521, 2015

14. Koch A, Jäger M, Völzke A, Grammatikos G, Meyer zu Heringdorf D, Huwiler A, and Pfeilschifter JM.Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration. Biol Chem., 396(6-7): 803-12, 2015

15. Iozzo RV, Schaefer L: Proteoglycan form and function: A comprehensive nomenclature of proteoglycans. Matrix Biol, 42: 11-55, 2015

16. Thangaraj G, Christophel J, Bachmann G, Greif A, and Layer, PG. PEDF counteracts DL-α-aminoadipate toxicity and rescues gliotoxic damages in RPE-free chicken retinal explants. Exp Eye Res., 134: 111-2, 2015

17. Theocharis AD, Skandalis SS, Neill T, Multhaupt HA, Hubo M, Frey H, Gopal S, Gomes A, Afratis N, Lim HC, Couchman JR, Filmus J, Ralph D S, Schaefer L, Iozzo RV, and Karamanos NK. Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. Biochim Biophys Acta, 1855: 276-300, 2015

18. Bryant CE, Gay NJ, Heymans S, Sacre S, Schaefer L, and Midwood KS: Advances in Toll-like Receptor biology: Modes of activation by diverse stimuli. Crit Rev Biochem Mol Biol, 10: 1-21, 2015

19. Awwad K, Hu J, Shi L, Mangels N, Abdel Malik R, Zippel N, Fisslthaler B, Eble JA, Pfeilschifter J, Popp R, Fleming I. Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis. Cardiovasc Res., 106(2): 284-94, 2015

20. Steinmeyer N, Doller A, Biyanee A, Brauß T, Schmid T, Pfeilschifter J, and Eberhardt W. Lymphotoxin alpha, a novel target of posttranscriptional gene regulation by HuR in HepG2 cells. FEBS Lett., 589(15): 1943-50, 2015

21. Ohnheiser J, Ferlemann E, Haas A, Müller JP, Werwein E, Fehler O, Biyanee A, and Klempnauer KH. Programmed cell death 4 protein (Pdcd4) and homeodomain-interacting protein kinase 2 (Hipk2) antagonistically control translation of Hipk2 mRNA. Biochim Biophys Acta, 1853(7): 1564-73, 2015

22. Schwalm S, Timcheva TM, Filipenko I, Ebadi M, Hofmann LP, Zangemeister-Wittke U, Pfeilschifter J, and Huwiler A. Sphingosine kinase 2 deficiency increases proliferation and migration of renal mouse mesangial cells and fibroblasts. Biol Chem, 396(6-7): 813-25, 2015

23. Brunkhorst R, Friedlaender F, Ferreirós N, Schwalm S, Koch A, Grammatikos G, Toennes S, Foerch C, Pfeilschifter J, and Pfeilschifter W. Alterations of the Ceramide Metabolism in the Peri-Infarct Cortex Are Independent of the Sphingomyelinase Pathway and Not Influenced by the Acid Sphingomyelinase Inhibitor Fluoxetine. Neural Plast., 2015: 503079, 2015.

24. Berner A, Bachmann M, Pfeilschifter J, Kraiczy P, and Mühl H. Interferon-α curbs production of Interleukin-22 by human peripheral blood mononuclear cells exposed to live Borrelia burgdorferi. J Cell Mol Med, 19(10): 2507-2511, 2015

25. Burkhardt U, Beyer S, and Klein J. Role of phospholipases D1 and 2 in astroglial proliferation: effects of specific inhibitors and genetic deletion. Eur J Pharmacol., 761: 398-404, 2015

26. Urtz N, Gaertner F, von Bruehl ML, Chandraratne S, Rahimi F, Zhang L, Orban M, Barocke V, Beil J, Schubert I, Lorenz M, Legate KR, Huwiler A, Pfeilschifter J, Beerli C, Ledieu D, Persohn E, Billich A, Baumruker T, Mederos Y, Schnitzler M, and Massberg S. Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro And In Vivo. Circ Res., 117: 376-387, 2015

27. Gubbiotti MA, Neill T, Frey H, Schaefer L, and Iozzo RV. Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy. Matrix Biol., 48:14-25, 2015

28. Härdle L, Bachmann M, Bollmann F, Pautz A, Schmid T, Eberhardt W, Kleinert H, Pfeilschifter J, and Mühl, H.Tristetraprolin regulation of interleukin-22 production. Sci Rep., 5: 15112, 2015.

29. Stammler D, Eigenbrod T, Menz S, Frick JS, Sweet JM, Kelly GM, Jantsch J, Siegert I, Wölfle S, Julian D. Langer JD, Oehme I, Schaefer L, Heeg K, Dalpke AH, and Bode KA. Inhibition of histone deacetylases permits LPS-mediated secretion of bioactive IL-1? via a caspase-1-independent mechanism. J Immunol., 195: 5421-31, 2015.

30. Grammatikos G, Ferreiròs N, Waidmann O, Bon D, Schroeter S, Koch A, Herrmann E, Zeuzem S, Kronenberger B, and Pfeilschifter J. Associate with Hepatic Decompensation and Survival in Patients with Cirrhosis. PLoS One. 2015 Sep 18;10(9):e0138130.

31. Imeri F, Blanchard O, Jenni A, Schwalm S, Wünsche C, Zivkovic A, Stark H, Pfeilschifter J, and Huwiler A. FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P(3) and phosphoinositide 3-kinase. Naunyn Schmiedebergs Arch Pharmacol. 388(12): 1283-92, 2015.

32. Lasch S, Müller P, Bayer M, Pfeilschifter JM, Luster AD, Hintermann E, and Christen U. Anti-CD3/anti-CXCL10 antibody combination therapy induces a persistent remission of type 1 diabetes in two mouse models. Diabetes, 64(12): 4198-211, 2015.

33. Wagner A, Köhm M, Nordin A, Svenungsson E, Pfeilschifter JM, and Radeke HH. Increased Serum Levels of the IL-33 Neutralizing sST2 in Limited Cutaneous Systemic Sclerosis. Scand J Immunol. 82(3): 269-274, 2015.

34. Pfarr K, Danciu C, Arlt O, Neske C, Dehelean C, Pfeilschifter JM, and Radeke HH. Simultaneous and dose dependent melanoma cytotoxic and immune stimulatory activity of betulin. PLoS One. 10(3)e0118802, 2015.

35. Schröder M, Arlt O, Schmidt H, Huwiler A, Angioni C, Pfeilschifter JM, Schwiebs A, and Radeke HH. Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. Biol Chem., 396(6-7): 795-802, 2015.

36. Syhr KM, Boosen M, Hohmann SW, Longen S, Köhler Y, Pfeilschifter J, Beck KF, Geisslinger G, Schmidtko A, and Kallenborn-Gerhardt W. The H(2)S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain. Brain Res., 1624: 380-9, 2015.

37. Olesch C, Sha W, Angioni C, Sha LK, Açaf E, Patrignani P, Jakobsson PJ, Radeke HH, Grösch S, Geisslinger G, von Knethen A, Weigert A, and Brüne B. MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer. Oncotarget, 6(12): 10284-96, 2015.

38. Christen U, Hintermann E. An Update on Animal Models of Autoimmune Hepatitis: Are we There Yet? Curr Pharm Des., 21(18): 2391-400, 2015.

39. Biyanee A, Singh P, and Klempnauer KH. Translation, Pdcd4 and eIF4A. Oncoscience. 2(9): 731-2, 2015.

40. Danciu C, Oprean C, Coricovac DE, Andreea C, Cimpean A, Radeke H, Soica C, and Dehelean C. Behaviour of four different B16 murine melanoma cell sublines: C57BL/6J skin. Int J Exp Pathol., 96(2): 73-80., 2015.

41. Meyer Dos Santos S, Blankenbach K, Scholich K, Dörr A, Monsefi N, Keese M, Linke B, Deckmyn H, Nelson K, Harder S. Platelets from flowing blood attach to the inflammatory chemokine CXCL16 expressed in the endothelium of the human vessel wall. Thromb Haemost., 114(2): 297-312, 2015.

42. Mauf S, Penna-Martinez M, Jentzsch T, Ackermann H, Henrich D, Radeke HH, Brück P, Badenhoop K, and Ramos-Lopez E. Immunomodulatory effects of 25-hydroxyvitamin D(3) on monocytic cell differentiation and influence of vitamin D(3) polymorphisms in type 1 diabetes. J Steroid Biochem Mol Biol., 147C:17-23, 2015

1. Brunkhorst R, Vutukuri R, and Pfeilschifter W. Fingolimod for the treatment of neurological diseases-state of play and future perspectives. Front Cell Neurosci. 8: 283, 2014

2. Schwalm S, Pfeilschifter J, and Huwiler A. Targeting the Sphingosine Kinase / Sphingosine 1-Phosphate Pathway to Treat Chronic Inflammatory Kidney Diseases. Basic Clin Pharmacol, 114(1): 44-49, 2014

3. Völzke A, Koch A, Meyer Zu Heringdorf D, Huwiler A, und Pfeilschifter J. Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. Biochim Biophys Acta, 1841(1): 11-21, 2014

4. Zeng-Brouwers J, Beckmann J, Nastase MV, Iozzo RV, and Schaefer L. De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways. Matrix Biol, 35: 132-142, 2014

5. Goyal A, Neill T, Owens RT, Schaefer L, and Iozzo RV. Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells. Matrix Biol, 35: 42-53, 2014

6. Morcavallo A, Buraschi S, Xu S-Q, Belfiore A, Schaefer L, Iozzo RV, and Morrione A. Decorin differentially modulates the activity of insulin receptor isoform A ligands. Matrix Biol, 35: 82-90, 2014

7. Ungerer C, Quade-Lyssy P, Radeke HH, Henschler R, Königs C, Köhl U, Seifried E, and Schüttrumpf J. Galectin-9 Is a Suppressor of T and B Cells and Predicts the Immune Modulatory Potential of Mesenchymal Stromal Cell Preparations. Stem Cells, 23(7): 755-766, 2014

8. Waidmann O, Kronenberger B, Scheiermann P, Köberle V, Mühl H, and Piiper A. Interleukin 22 serum levels are a negative prognostic indicator in patients with hepatocellular carcinoma. Hepatology, 59(3): 1207, 2014

9. Longen S, Woellhaf MW, Petrungaro C, Riemer J, and Herrmann JM. The disulfide relay of the intermembrane space oxidizes the ribosomal subunit mrp10 on its transit into the mitochondrial matrix. Dev Cell, 28(1): 30-42, 2014

10. Moreth K, Frey H, Hubo M, Zeng-Brouwers J, Nastase MV, Hsieh L T-H, Haceni R, Pfeilschifter J, Iozzo RV, and Schaefer L. Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury. Matrix Biol, 35: 143–151, 2014

11. Nastase MV, Iozzo RV, and Schaefer L. Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology. Biochim Biophys Acta, 1840: 2460-2470, 2014

12. Anders HJ, Schaefer L. Beyond Tissue Injury--Damage-Associated Molecular Patterns, Toll-Like Receptors, and Inflammasomes Also Drive Regeneration and Fibrosis. J Am Soc Nephrol, 25(7): 1387-1400, 2014

13. Grammatikos G, Mühle C, Ferreiros N, Schroeter S, Bogdanou D, Schwalm S, Hintereder G, Kornhuber J, Zeuzem S, Sarrazin C, and Pfeilschifter J. Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease. Biochim Biophys Acta, 1841(7): 1012-1020, 2014

14. Schürmann C, Goren I, Linke A, Pfeilschifter J, and Frank S. Deregulated unfolded protein response in chronic wounds of diabetic ob/ob mice: A potential connection to inflammatory and angiogenic disorders in diabetes-impaired wound healing.
    Biochem Biophys Res Commun, 446(1): 195-200, 2014

15. Winkler C, Doller A, Imre G, Badawi A, Schmid T, Schulz S, Steinmeyer N, Pfeilschifter J, Rajalingam K, and Eberhardt W. Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L. Cell Death & Disease, 5:e1321, 2014

16. Schaefer L. Proteoglycans, key regulators of cell–matrix dynamics. Matrix Biol, 35: 1-2, 2014

17. Bender C, Schlosser M, Christen U, Ziegler GA, and Achenbach P. GAD autoantibody affinity in schoolchildren from the general population. Diabetologia, 57(9): 1911-1918, 2014

18. Christen U and Hintermann E. Pathogen infection and autoimmune hepatitis. Int Rev Immunol, 33(4): 296-313, 2014

19. Christen, U. Pathogen infection and autoimmunity. Int Rev Immunol, 33(4): 261-265, 2014

20. Burkhardt U, Stegner D, Hattingen E, Beyer S, Nieswandt B, Klein J. Impaired brain development and reduced cognitive function in phospholipase D-deficient mice. Neurosci Lett., 572C: 48-52, 2014

21. Imeri F, Fallegger D, Zivkovic A, Schwalm S, Enzmann G, Blankenbach K, Meyer Zu Heringdorf D, Homann T, Kleuser B, Pfeilschifter J, Engelhardt B, Stark H, and Huwiler A. Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice. Neuropharmacology. 85: 314-327, 2014

22. Neill T, Schaefer L, and Iozzo RV. Pathogen infection and autoimmunity. Instructive Roles of Extracellular Matrix on Autophagy. Am J Pathol 184: 2146-53, 2014

23. Schürmann C, Schmidt N, Seitz O, Pfeilschifter J, and Frank S. Angiogenic response pattern during normal and impaired skin flap re-integration in mice: A comparative study. J Craniofac Surg,42(8): 1710-1716, 2014

24. Hsieh LT, Nastase MV, Zeng-Brouwers J, Iozzo RV, and Schaefer L. Soluble biglycan as a biomarker of inflammatory renal diseases.Int J Biochem Cell Biol 54C: 223-235, 2014

25. Arlt O, Schwiebs A, Japtok L, Rüger K, Katzy E, Kleuser B, and Radeke HH. Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo. Cell Physiol Biochem., 34(1): 27-44, 2014

26. Rüger K, Ottenlinger F, Schröder M, Zivković A, Stark H, Pfeilschifter JM, and Radeke HH. Modulation of IL-33/ST2-TIR and TLR signaling pathway by fingolimod and analogs in immune cells. Scand J Immunol., 80(6): 398-407, 2014

27. Goren I, Pfeilschifter J, and Frank S. Uptake of Neutrophil-Derived Ym1 Protein Distinguishes Wound Macrophages in the Absence of Interleukin-4 Signaling in Murine Wound Healing.Am J Pathol., 184(12): 3249-61, 2014

28. Bingold TM, Just L, Cuca C, Zacharowski K, Mönch C, Mühl H, Wissing H, Pipa G, Rosenberger P, Bechstein WO, Paulus P, Scheller B. Preoperative interleukin-22 values add valuable information for outcome prediction following orthotopic liver transplantation: a preliminary study. Ann Transpl. 19: 503-512, 2014

29. Schaefer L. Complexity of danger: The diverse nature of damage-associated molecular patterns. J Biol Chem, 289(51): 35237-35245, 2014

30. Pastukhov O, Schwalm S, Römer I, Zangemeister-Wittke U, Pfeilschifter J, and Huwiler A.Ceramide kinase contributes to proliferation but not to prostaglandin E2 formation in renal mesangial cells and fibroblasts. Cell Physiol Biochem, 34(1): 119-33, 2014

31. Pastukhov O, Schwalm S, Zangemeister-Wittke U, Fabbro D, Bornancin F, Japtok L, Kleuser B, Pfeilschifter J, and Huwiler A. The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death. Br J Pharmacol., 171(24): 5829-5844, 2014

32. Poluzzi C, Casulli J, Goyal A, Mercer TJ, Neill T, and Iozzo RV. Endorepellin evokes autophagy in endothelial cells. J Biol Chem, 289(23): 16114-16128, 2014

33. Bollmann F, Art J, Henke J, Schrick K, Besche V, Bros M, Li H, Siuda D, Handler N, Bauer F, Erker T, Behnke F, Mönch B, Härdle L, Hoffmann M, Chen CY, Förstermann U, Dirsch VM, Werz O, Kleinert H, Pautz A. Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity. Nucleic Acids Res., 42(20): 12555-69, 2014

1. Breth B, Odenbach D, Yemelin A, Schlinck N, Schröder M, Bode M, Antelo L, Andresen K, Thines E, and Foster AJ. The role of the Tra1p transcription factor of Magnaporthe oryzae in spore adhesion and pathogenic development. Fungal Genet Biol., 57: 11-22, 2013

2. Eisel F, Boosen M, Beck M, Heide H, Wittig I, Beck KF, and Pfeilschifter, J.. Platelet-derived growth factor triggers PKA-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells. Biochem Pharmacol., 85(1):101-8, 2013

3. Bachmann M., Ulziibat S., Härdle L., Pfeilschifter J., and Mühl H. IFNa converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets. Biochem Pharmacol., 85(3): 396-403, 2013

4. Masseli J, Bertog S, Stanczak L, Blankenbach K, Majunke N, Reiffenstein I, Renkhoff K, Lehn K, Wunderlich N, and Sievert H. Transcatheter closure of multiple interatrial communications. Catheter Cardiovasc Interv., 81(5): 825-836, 2013

5. Rose R, Penna-Martinez M, Klahold E, Kärger D, Shoghi F, Kahles H, Bayer M, Hintermann E, Pfeilschifter JM, Badenhoop K, Ramos-Lopez E, and Christen U. Influence of the vitamin D plasma level and vitamin D related genetic polymorphisms on the immune status of patients with type 1 diabetes: A pilot study. Clin Exp Immunol, 171(2): 171-85, 2013

6. Ehser J, Holdener M, Christen S, Bayer M, Pfeilschifter JM, Hintermann E, Bogdanos D, and Christen U. Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis, J Autoimmun 42: 39-49, 2013

7. Christen U and von Herrath M. Virus-induced mouse models for type 1 diabetes. In: Diabetes and Viruses, Springer Verlag, Germany (eds: Keith Taylor, Heikki Hyöty, Antonio Toniolo and Arie Zuckerman), 2013

8. Brauer F, Schmidt K, Zahn RC, Richter C, Radeke HH, Schmitz JE, von Laer D, and Egerer L. A rationally engineered anti-HIV peptide fusion inhibitor with greatly reduced immunogenicity. Antimicrob Agents Chemother., 57(2): 679-88. 2013

9. Schwalm S, Pfeilschifter J, and Huwiler A. Sphingosine-1-phosphate: A Janus-faced mediator of fibrotic diseases. Biochim Biophys Acta, 1831(1): 239-50, 2013

10. Scheiermann P, Bachmann M, Goren I, Zwissler B, Pfeilschifter J, and Mühl H. Application of interleukin-22 mediates protection in experimental acetaminophen-induced acute liver injury. Am J Pathol, 182(4):1107-13, 2013

11. Frey H, Schroeder N, Manon-Jensen T, Iozzo RV, and Schaefer L. Biological interplay between proteoglycans and their innate immune receptors in inflammation. FEBS J, 280: 2165-79, 2013

12. Neill T, Jones HR, Crane-Smith Z, Owens RT, Schaefer L, and Iozzo RV. Decorin evokes rapid secretion of thrombospondin-1 in basal breast carcinoma cells via inhibition of RhoA/ROCK. FEBS J 280: 2353-68, 2013

13. Mühl, H. Pro-Inflammatory Signaling by IL-10 and IL-22: Bad Habit Stirred up by Interferons? Front. Immunol, 2013; 4: 18, doi: 10.3389/fimmu.2013.00018

14. Mühl H, Scheiermann P, Bachmann M, Härdle L, Heinrichs A, and Pfeilschifter J. IL-22 in tissue protective therapy. Br J Pharmacol, 169(4): 761-71. 2013

15. Christen S, Coppieters K, Rose K, Holdener M, Bayer M, Pfeilschifter JM, Hintermann E, von Herrath MG, Aurrand-Lions M, Imhof BA, and Christen U. Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice. PLoS One, 8(1):e54675, 2013

16. Doberstein K, Steinmeyer N, Hartmetz AK, Eberhardt W, Mittelbronn M, Harter PN, Juengel E, Blaheta R, Pfeilschifter J, and Gutwein P. MicroRNA-145 Targets the Metalloprotease ADAM17 and Is Suppressed in Renal Cell Carcinoma Patients.Neoplasia, 15(2): 218-30, 2013

17. Veerkamp J, Rudolph F, Cseresnyes Z, Priller F, Otten C, Renz M, Schaefer L, and Abdelilah-Seyfried S. Unilateral dampening of Bmp activity by Nodal generates cardiac left-right asymmetry. Dev Cell 24: 660-7, 2013

18. Bergis D, Kassis V, Ranglack A, Koeberle V, Piiper A, Kronenberger B, Zeuzem S, Waidmann O, and Radeke HH. High serum levels of the interleukin-33 receptor soluble ST2 as a negative prognostic factor in hepatocellular carcinoma. Transl Oncol,, 6(3): 311-18, 2013

19. Brauer F, Schmidt K, Zahn RC, Richter C, Radeke HH, Schmitz JE, von Laer D, and Egerer L. A rationally engineered anti-HIV peptide fusion inhibitor with greatly reduced immunogenicity. Antimicrob Agents Chemother., 57(2): 679-88, 2013

20. Koch A, Pfeilschifter J, Huwiler A. Sphingosine 1-Phosphate in Renal Diseases. Cell Physiol Biochem. 31(6): 745-60, 2013

21. Meyer zu Heringdorf DM, Ihlefeld K, Pfeilschifter J. Pharmacology of the sphingosine-1-phosphate signalling system. Handb Exp Pharmacol. 215: 239-53, 2013

22. Giegold O, Ogrissek N, Richter C, Schröder M, Herrero San Juan M, Pfeilschifter JM, Radeke HH. CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation. J. Immunol. 190: 3696-705, 2013

23. Giegold O, Ogrissek N, Radeke HH. Response to comment on „CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation“. J. Immunol. 191(2): 525-526, 2013

24. Buraschi S, Neill T, Goyal A, Poluzzi C, Smythies J, Owens RT, Schaefer L, Torres A, and Iozzo RV. Decorin causes autophagy in endothelial cells via Peg3. Proc Natl Acad Sci USA 110(28): E2582-91, 2013

25. Coppieters KT, Amirian N, Pagni PP, Baca Jones C, Wiberg A, Lasch S, Hintermann E, Christen U, and von Herrath MG. Functional Redundancy of CXCR3/CXCL10. Signaling in the Recruitment of Diabetogenic Cytotoxic T Lymphocytes to Pancreatic Islets in a Virally Induced Autoimmune Diabetes Model. Diabetes, 62(7): 2492-9, 2013

26. Hintermann E, Ehser J, Bayer M, Pfeilschifter JM, and Christen U. Mechanism of autoimmune hepatic fibrogenesis induced by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6. J. Autoimmun., 44: 49-60, 2013

27. Balah A, Mühl H, Pfeilschifter J, and Akool el-S. Molecular mechanisms of PDGF-AA expression induced by the dsRNA-mimetic poly (I:C) and IL-18. Biochem Biophys Res Commun., 435(4): 691-5, 2013

28. Doller A, Schulz S, Pfeilschifter J, and Eberhardt W. RNA-dependent association with myosin IIA promtes F-actin-guided trafficking of the ELAV-like protein HuR to polysomes. Nucleic Acids Res., 41(19): 9152-9167, 2013

29. Schulz S, Doller A, Pendini NR, Wilce JA, Pfeilschifter J, and Eberhardt W. Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA-binding protein HuR. Cell Signal., 25(12): 2485-2495, 2013

30. Brunkhorst R, Kanaan N, Koch A, Ferreirós N, Mirceska A, Zeiner P, Mittelbronn M, Derouiche A, Steinmetz H, Foerch C, Pfeilschifter J, Pfeilschifter W. FTY720 treatment in the convalescence period improves functional recovery and reduces reactive astrogliosis in photothrombotic stroke. PLoS One 31; 8(7): e70124, 2013

31. Koch A, Völzke A, Puff B, Blankenbach K, Meyer Zu Heringdorf D, Huwiler A, Pfeilschifter J. PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca2+]i increases in renal mesangial cells. Biochim Biophys Acta, 1831(11): 1634-1643, 2013

32. Babelova A, Jansen F, Sander K, Löhn M, Schaefer L, Rütten H, Stark H, Amann K, Pavenstädt H, Jung O, and Brandes RP. Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease. PLoS One 8(11): e80328, 2013

33. Christen U. The role of autoantibodies in autoimmune hepatitis type 2. Immunotherapy. 5(3): 247-56, 2013

34. Zhu X, Wang Y, Schwiebs A, and Walther T. Chimeric natriuretic peptide ACNP stimulates both natriuretic peptide receptors, the NPRA and NPRB. Mol Cell Endocrinol. 366(1): 117-23, 2013

35. Gäbel K, Schmitt J, Schulz S, Näther DJ, and Soppa J. A Comprehensive Analysis of the Importance of Translation Initiation Factors for Haloferax volcanii Applying Deletion and Conditional Depletion Mutants. PLoS One, 8(11), e77188, 2013

36. Del Galdo S, Vettel C, Meyer zu Heringdorf DM and Wieland T.The activation of RhoC in vascular endothelial cells is required for the S1P receptor type 2-induced inhibition of angiogenesis.Cell Signal. 25(12): 2478-84, 2013

1. Akool ES, Gauer S, Osman B, Doller A, Schulz S, Geiger H, Pfeilschifter J, and Eberhardt W. Cyclosporin A and tacrolimus induce renal ERK1/2 pathway via ROS-induced and metalloproteinase-dependent EGF-receptor signaling. Biochem. Pharmacol. Biochem Pharmacol, 83(2):286-95, 2012

2. Bauer K, Dürrwald R, Schlegel M, Pfarr K, Topf D, Wiesener N, Dahse HM, Wutzler P, and Schmidtke M. Neuraminidase inhibitor susceptibility of swine influenza A viruses isolated in Germany between 1981 and 2008. Med Microbiol Immunol, 201(1): 61-72, 2012.

3. Koch A, Völzke A, Wünsche C, Meyer zu Heringdorf D, Huwiler A, and Pfeilschifter J. Thiazolidinedione dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells. Br J Pharmacol 166(3):1018-1032, 2012

4. Rudloff I, Bachmann M, Pfeilschifter J, and Mühl H. Mechanisms of rapid induction of Interleukin-22 in activated T-cells and its modulation by Cyclosporin A. J Biol Chem, 287(7): 4531-43, 2012

5. Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, and Iozzo RV. Decorin antagonizes the angiogenic network: concurrent inhibition of Met, HIF-1α and VEGFA and induction of thrombospondin-1 and TIMP3. J Biol Chem 287(8): 5492-506, 2012

6. Seitz O, Schürmann C, Pfeilschifter J, Frank S, and Sader R. Identification of the Fra-1 transcription factor in healing skin flaps transplants: A potential role as a negative regulator of VEGF release from keratinocytes. J Craniomaxillofac Surg 40(4):379-386, 2012

7. Eberhardt W, Doller A, and Pfeilschifter J. Regulation of the mRNA-binding protein HuR by posttranslational modification: spotlight on phosphorylation. Curr Protein Pept Sci, 13(4): 380-390, 2012

8. Schaefer L, Iozzo RV: Small leucine-rich proteoglycans, at the crossroad of cancer growth and inflammation. Curr Opin Genet Dev 22(1): 56-57, 2012

9. Tzieply N, Kuhn AM, Morbitzer D, Namgaladze D, Heeg A, Schaefer L, von Knethen A, Jensen LE, and Brüne B. OxLDL inhibits LPS-induced IFNg expression by Pellino3- and IRAK1/4-dependent modification of TANK. Cell Signal 24(6): 1141-49, 2012

10. Schürmann C, Linke A, Engelmann-Pilger K, Steinmetz C, Mark M, Pfeilschifter J, Klein T, and Frank S. The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Attenuates Inflammation and Accelerates Epithelialization in Wounds of Diabetic ob/ob Mice. J Pharmacol Exp Ther 342(1):71-80, 2012

11. Hassan MI, Boosen M, Schaefer L, Kozlowska J, Eisel F, von Knethen A, Beck M, Hemeida RA, El-Moselhy MA, Hamada FM, Beck KF, and Pfeilschifter J. Platelet-derived growth factor-BB induces cystathionine γ-lyase expression in rat mesangial cells via a redox-dependent mechanism. Br J Pharmacol, 166(8): 2231-2242, 2012

12. Pfeilschifter W, Bohmann F, Baumgarten P, Mittelbronn M, Pfeilschifter J, Lindhoff-Last E, Steinmetz H, Foerch C.Thrombolysis with recombinant tissue plasminogen activator under dabigatran anticoagulation in experimental stroke. Ann Neurol, 71(5): 624-33, 2012

13. Allam R, Scherbaum CR, Darisipudi MN, Mulay SR,  Hägele H, Lichtnekert J, Hagemann JH, Rupanagudi KV, Ryu M, Schwarzenberger C, Hohenstein B, Hugo C, Uhl B, Reichel CA, Krombach F, Monestier M, Moreth K, Schaefer L, and Anders HJ. Histones from dying renal cells aggravate acute kidney injury via TLR-2 and -4. J Am Soc Nephrol 23: 1375-1388, 2012

14. Wittmann M, Doble R, Bachmann M, Pfeilschifter J, Werfel T, and Mühl H. IL-27 regulates IL-18 Binding Protein in skin resident cells. PLoS One, 7(6): e38751, 2012

15. Moreth K, Iozzo RV, Schaefer L. Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation. Cell Cycle II: 2084-91, 2012

16. Schroeder N, Chung CS, Chen CH, Liao CL, Chang W. The lipid raft-associated protein CD98 is required for vaccinia virus endocytosis. J Virol 86: 4868-82, 2012.

17. Neill T, Schaefer L, Iozzo RV. Decorin, a guardian from the matrix. Am J Pathol 181: 380-387, 2012

18. Babelova A, Avaniadi D, Jung O, Fork C, Beckmann J, Kosowski J, Weissmann N, Anilkumar N, Shah AM, Schaefer L, Schröder K, Brandes RP Role of Nox4 in murine models of kidney disease. Free Radic Biol Med 53: 842-853, 2012

19. Nastase MV, Young MF, Schaefer L. Biglycan: a multivalent proteoglycan providing structure and signals. J Histochem Cytochem 60: 963 -75, 2012

20. Kronenberger B, Rudloff I, Bachmann M, Brunner F, Kapper L, Filmann N, Waidmann O, Herrmann E, Pfeilschifter J, Zeuzem S, Piiper A, and Mühl H. Interleukin-22 predicts severity and death in advanced liver cirrhosis: A prospective cohort study. BMC Medicine, 10 (1), 102, 2012

21. Ihlefeld K, Claas RF, Koch A, Pfeilschifter JM, Meyer Zu Heringdorf D. Evidence for a link between histone deacetylation and Ca2+ homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts. Biochem J, 447(3): 457-464, 2012

22. Hintermann E, Ehser J, Christen U. The CYP2D6 animal model: how to induce autoimmune hepatitis in mice. J Vis Exp, 60. pii: 3644, doi: 10.3791/3644, 2012

23. Christen U, Bender C, von Herrath MG. Infection as a cause of type 1 diabetes? Curr Opin Rheumatol, 24(4): 417-423, 2012

24. Sadik CD, Noack B, Schacher B, Pfeilschifter J, Mühl H, and Eickholz P. Cytokine production by leukocytes of Papillon-Lefevre syndrome patients in whole blood cultures. Clin Oral Investig., 16(2): 591-7, 2012

25. Buraschi S, Neill T, Owens RT, Iniguez LA, Purkins G, Vadigepalli R, Evans B, Schaefer L, Peiper SC, Wang Z, and Iozzo RV. Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model. PLoS One 7(9): e45559, 2012; doi: 10.1371s

26. Bachmann M, Scheiermann P, Härdle L, Pfeilschifter J, and Mühl H. IL36γ/IL1F9 - an innate T-bet target in myeloid cells.J Biol Chem., 287(50): 41684-96, 2012

27. Zechner PM, Seibel A, Aichinger G, Steigerwald M, Dorr K, Scheiermann P, Schellhaas S, Cuca C, and Breitkreutz R.Lung ultrasound in acute and critical care medicine. Anaesthesist. 2012 Jul;61(7):608-17. German.

28. Imre G, Heering J, Takeda AN, Husmann M, Thiede B, zu Heringdorf DM, Green DR, van der Goot FG, Sinha B, Dötsch V, Rajalingam K. Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis. EMBO J, 31(11): 2615-2628, 2012

29. Japtok L, Schaper K, Bäumer W, Radeke HH, Jeong SK, and Kleuser B. Sphingosine1-Phosphate Modulates Antigen Capture by Murine Langerhans Cells via the S1P(2) Receptor Subtype. PLoS One, 7(11): e49427, 2012; doi:10.1371

30. Ferreirós N, Labocha S, Schröder M, Radeke HH, and Geisslinger G. LC-MS/MS
determination of FTY720 and FTY720-phosphate in murine intracellular compartments and human plasma. J Chromatogr B Analyt Technol Biomed Life Sci, 887-888: 122-7, 2012

31. Reuter KC, Grunwitz CR, Kaminski BM, Steinhilber D, Radeke HH, and Stein J. Selective glucocorticoid receptor agonists for the treatment of inflammatory bowel disease: studies in mice with acute trinitrobenzene sulfonic acid colitis. J Pharmacol Exp Ther, 341(1): 68-80, 2012

1. Hoegl S, Bachmann M, Scheiermann P, Goren I, Hofstetter C, Pfeilschifter J, Zwissler B, and Mühl H. Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury. Am J Respir Cell Mol Biol, 44(3):369-76, 2011

2. Osman B, Akool ES, Doller A, Müller R, Pfeilschifter J, and Eberhardt W. Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin. Biochem Pharmacol, 81(1):1200-7, 2011

3. Schaefer L. Small leucine-rich proteoglycans in kidney disease. J Am Soc Nephrol, 22:1200-1207, 2011

4. Mühl H and Pfeilschifter J. Pharmakogenetik and Pharmakogenomik von Methotrexat: Aktuelle Bestandsaufnahme und neue Aspekte. Z Rheumatol, 70(2):101-7, 2011

5. Doberstein K, Schramme A, Lee BS, Blaheta RA, Wedel S, Moch H, Schraml P, Pfeilschifter J, Kristiansen G and Gutwein P. L1-CAM expression in ccRCC correlates with shorter patients survival times and confers chemoresistance in renal cell carcinoma cells. Carcinogenesis, 32(3):262-70, 2011

6. Mühl H, Bachmann M and Pfeilschifter J. Inducible NO synthase and antibacterial host defense
in times of Th17/Th22/T22 immunity. Cell Microbiol, 13(3):340-8, 2011

7. Ter Braak M, Claas RF, Hegen B, Labocha S, Ferreirós N, Pfeilschifter J, Huwiler A, van Echten-Deckert G, Meyer Zu Heringdorf D. Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator, Biochem Pharmacol, 81(5):617-25, 2011

8. Seitz O, Schürmann C, Hermes N, Müller E, Pfeilschifter J, Frank S, and Goren I. Wound healing in mice with high-fat diet- or ob gene-induced diabetes-obesity syndromes: A comparative study, Exp Diabetes Research, doi:10.1155/2010/476969, 2011

9. Huwiler A, Kotelevets N, Xin C, Pastukhov O, Pfeilschifter J, Zangemeister-Wittke U.
Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage. Brit J Pharmacol, 162(2):532-43, 2011

10. Scheiermann P, Beiras-Fernandez A, Mutlak H, and Weis F. The protective effects of levosimendan on ischemia/reperfusion injury and apoptosis. Recent Pat Cardiovasc Drug Discov, 6(1):20-6, 2011

11. Scheiermann P, Ott J, Hoegl S, Hecker M, Hofstetter C,  Seeger W, Zwissler B, Bausch B, Boost KA, and Mayer K.Effects of short-term infusion of lipid emulsions on pro-inflammatory cytokines and lymphocyte apoptosis in septic and non-septic rats. Brit J Nutr, 106(1):27-32, 2011

12. Scheiermann P, Hoegl S, Hofstetter C, Pfeilschifter J, Zwissler B, Mühl H, Boost KA, and Bertram Scheller. Comparing hemodynamics, blood gas analyses and proinflammatory cytokines in endotoxemic and severely septic rats. Int. Immunpharmacol, 11(6):719-23, 2011

13. Doller A, Winkler C, Azrilian I, Schulz S, Hartmann S, Pfeilschifter J, Eberhardt W. High constitutive HuR phosphorylation at Ser 318 by PKC{delta} propagates tumor relevant functions in colon carcinoma cells. Cacrinogenesis, 32(5):676-85, 2011

14. Korfei M, Schmitt S, Ruppert C, Henneke I, Markart P, Loeh B, Mahavadi P, Wygrecka M, Klepetko W, Fink L, Bonniaud P, Preissner KT, Lochnit G, Schaefer L, Seeger W, Guenther A: Comparative Proteomic Analysis of Lung Tissue from Patients with Idiopathic Pulmonary Fibrosis (IPF) and Lung Transplant Donor Lungs. J Proteom Res, 10:2185-205, 2011

15. Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I.SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature, 471 (7340):637-41, 2011

16. Bihrer V, Friedrich-Rust M, Kronenberger B, Forestier N, Haupenthal J, Shi Y, Peveling-Oberhag J, Radeke HH, Sarrazin E, Zeuzem S, Waidmann O, and Piiper A. Serum miR-122 as a biomarker of necroinflammation in patients with chronic hepatitis C virus infection. Am J Gastroenterol ., 106:1663-1669; doi:10.1038/ajg.2011.161, 2011

17. Christen U and von Herrath MG. Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference? Cell Mol Immunol, 8(3):193-8, 2011

18. Christen S, Holdener M, Beerli C, Thoma G, Bayer M, Pfeilschifter JM, Hintermann E, Zerwes HG, and Christen U.Small molecule CXCR3 antagonist NIBR2130 has only a limited impact on type 1 diabetes in a virus-induced mouse model. Clin Exp Immunol, 165(3):318-28, 2011

19. Rosenkranz AC, Rauch BH, Doller A, Eberhardt W, Böhm A, Bretschneider E, and Schrör K. Regulation of human vascular protease-activated receptor-3 through mRNA stabilisation and the transcription factor NFAT. Mol Pharmacol, 80(2): 337-44, 2011

20. Melchior-Becker A, Dai G, Ding Z, Schaefer L, Schrader J, Young MF, and Fischer JW. Deficiency of biglycan causes cardiac fibroblasts to differentiate into a myofibroblast phenotype. J Biol Chem, 286:17365-75, 2011

21. Schröder M, Richter C, Juan MH, Maltusch K, Giegold O, Quintini G, Pfeilschifter JM, Huwiler A,and Radeke HH. The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. Mol Immunol, 48 (9-10):1139-48, 2011

22. Thompson J, Wilson P, Brandewie K, Taneja D, Schaefer L, Mitchell B, and Tannock LR. Renal Accumulation of Biglycan and Lipid Retention Accelerates Diabetic Nephropathy, Am J Pathol, 179:1179-87, 2011

23. Lee SB, Doberstein K, Baumgarten P, Wieland A, Ungerer C,  Bürger C, Hardt K,  Boehncke WH,  Pfeilschifter J, Mihic-Probst D,  Mittelbronn M and  Gutwein P. PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells. PLoS One. 6(8):e22312, 2011

24. Jobi K, Rauch BH, Dangwal S, Freidel K, Eberhardt W, Fischer JW, Schrör K, Doller A, Rosenkranz AC. Redox-Regulation of human protease-activated receptor-2 by activated factor X. Free Radic Biol Med. , 51(9):1758-64, 2011

25. Patra C, Diehl F, Ferrazzi F, van Amerongen MJ, Novoyatleva T, Schaefer L, Mühlfeld C, Jungblut B, Engel FB.Nephronectin regulates via BMP4-HAS2 signaling the differentiation of the atrio-ventricular canal in zebrafish. Development, 138:4499-509, 2011

26. Hintermann E, Holdener M, Bayer M, Loges S, Pfeilschifter JM, Granier C, Manns MP, Christen U. Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model. J Autoimmun. 37(3):242-53, 2011.

27. Doberstein K, Pfeilschifter J, Gutwein P. The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma. Carcinogenesis, 32(11):1713-23, 2011

28. Kern M, Winkler C, and Simon J. Respiratory nitrogen metabolism and nitrosative stress defence in ϵ-proteobacteria: the role of NssR-type transcription regulators. Biochem Soc Trans, 39(1):299-302, 2011

29. Brehm C, Huenecke S, Quaiser A, Esser R, Bremm M, Kloess S, Soerensen J, Kreyenberg H, Seidl C, Becker P, Mühl H, Klingebiel T, Bader P, Passweg JR, Schwabe D, and Koehl U. IL-2 Stimulated but Not Unstimulated NK Cells Induce Selective Disappearance of Peripheral Blood Cells: Concomitant Results to a Phase I/II Study. PLoS One, 6(11):e27351, 2011

30. Popovic ZV, Wang S, Papatriantafyllou M, Kaya Z, Porubsky S, Meisner M, Bonrouhi M, Burgdorf S, Young MF, Schaefer L, and Gröne HJ. The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis. J Immunol 187:6217-26, 2011

31. Pankonien I, Alvarez JL, Doller A, Köhncke C, Rotte D, Regitz-Zagrosek V, Morano I, and Haase H. Ahnak1 is a tuneable modulator of cardiac Ca(v)1.2 calcium channel activity. J Muscle Res Cell Motil 32(4-5):281-90, 2011

32. Pfeilschifter W, Spitzer D, Pfeilschifter J, Steinmetz H, and Foerch C. Warfarin Anticoagulation Exacerbates the Risk of Hemorrhagic Transformation after rt-PA Treatment in Experimental Stroke: Therapeutic Potential of PCC. PLoS One, 6(10): e26087, 2011

33. Pfeilschifter W, Czech-Zechmeister B, Sujak M, Foerch C, Wichelhaus TA, and Pfeilschifter J. Treatment with the immunomodulator FTY720 does not promote spontaneous bacterial infections after experimental stroke in mice. Exp Transl Stroke Med., 3:2, 2011

34. Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhão JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, and Schaefer L. Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and miR-21. Sci Signal. 4, ra75, 2011, Summary, Abstract, Reprint, Full Text

35. Bihrer V, Waidmann O, Friedrich-Rust M, Forestier N, Susser S, Haupenthal J, Welker M, Shi Y, Peveling-Oberhag J, Polta A, von Wagner M, Radeke HH, Sarrazin C, Trojan J, Zeuzem S, Kronenberger B, and Piiper A. Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma PloS One, 6(10):e26971, 2011

36. Pfeilschifter W, Czech-Zechmeister B, Sujak M, Mirceska A, Koch A, Rami A, Steinmetz H, Foerch C, Huwiler A, and Pfeilschifter J. Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia. Biochem Biophys Res Commun. 413(2):212-7, 2011

37. Oberoi TK, Dogan T, Hocking JC, Scholz RP, Mooz J, Anderson CL, Karreman C, Meyer zu Heringdorf D, Schmidt G, Ruonala M, Namikawa K, Harms GS, Carpy A, Macek B, Köster RW, and Rajalingam K. IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J, 31(1):14-28, 2011

38. Seitz O, Dehner JF, Schürmann C, Landes c, Frank S, Schlee M, and Sader R. Periimplantitis: Fakten und Visionen. Der MKG-Chirurg, 2011/4: DIO:10.1007/s12285-010-0176-0, 2011

1. Claas RF, ter Braak M, Hegen B, Hardel V, Angioni C, Schmidt H, Jakobs KH, Van Veldhoven PP, and Meyer zu Heringdorf D. Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts. Cell Signal , 22(3): 476-483, 2010

2. Schäfer L and Schäfer RM. Proteoglycans: From structural compounds to signaling moleculs. Cell Tissue Res, 339(1): 237-246, 2010

3. Doller A, Schlepckow K, Schwalbe H, Pfeilschifter J, and Eberhardt W. Tandem phosphorylation of serine 221 and 318 by PKCd coordinates mRNA binding and nucleo-cytoplasmic shuttling of HuR. Mol Cell Biol, 30(6): 1397-1410, 2010

4. Wang S, Schmaderer C, Kiss E, Schmidt C, Bonrouhi M, Porubsky S, Gretz N, Schaefer L, Kirschning CJ, Popovic ZV, and Gröne HJ. Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88 and TRIF depending signaling. Dis Model Mech, 3(1-2): 92-103, 2010

5. Lee SB, Schramme A, Doberstein K, Dummer R, Abdel-Bakky MS, Keller S, Altevogt P, Oh ST, Reichrath J, Oxmann D, Pfeilschifter J, Mihic-Probst D, and Gutwein P. ADAM10 is upregulated in melanoma metastasis compared to primary melanoma. J Invest Dermatol, 130(3): 763-773, 2010

6. Linke A, Goren I, Bösl MR, Pfeilschifter J, and Frank S. The suppressor of cytokine signaling (SOCS)-3 determines keratinocyte proliferative and migratory potential during skin repair. J Invest Dermatol, 130(3): 876-885, 2010

7. Linke A, Goren I, Bösl MR, Pfeilschifter J, and Frank S. Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1. J Invest Dermatol, 130(3): 866-875, 2010

8. Christen U, Hintermann E, Holdener M, and von Herrath MG. Viral triggers for autoimmunity: Is the "glass of molecular mimicry" half full or half empty? J Autoimmun, 34(1): 38-44, 2010

9. Kern M, Eisel F, Scheithauer J, Kranz RG, and Simon J. Substrate specifity of three cytochrome c haemlyase isoenzymes from Woliella succinogenes:unconventional haem C binding motifs are not sufficient for haem C attachment by NrfI and CcsA1. Mol Microbiol, 75(1): 122-137, 2010

10. Koenig M, Huenecke S, Salzmann-Manrique E, Esser R, Quaritsch R, Steinhilber D, Radeke HH, Martin H, Bader P, Klingebiel T, Schwabe D, Schneider G, Lehrnbecher T, Orth A, Koehl U. Multivariate analyses of immune reconstitution in children after allo-SCT: risk-estimationbased on age-matched leukocyte sub-population. Bone Marrow Transplant, 45(4): 613-621, 2010

11. Ludwig RJ, Bergmann P, von Stebut E; Radeke HH, Gille J, Henschler R, Kaufmann R, Pfeilschifter JM, and 
Boehncke WH. Platelet, non endothelial P-selectin expression contributes to generation of immunity in cutaneous contact hypersensitivity. Am J Pathol, 176(3): 1339-1345, 2010

12. Gutwein P, Schramme A, Abdel-Bakky MS, Doberstein K, Hauser IA, Ludwig A, Altevogt P, Gauer S, Hillmann A, Weide T, Jespersen C, Eberhardt W , Pfeilschifter J. ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases. Journal of Biomedical Science, 17: 3, 2010

13. Schaefer L. Extracellular matrix molecules: endogenous danger signals as a new drug targets in kidney diseases. 
Curr Opin Pharmacol, 10(2): 185-190, 2010

14. Nold-Petry CA, Lehrnbecher T, Jarisch A, Schwabe D, Pfeilschifter JM, Mühl H, and Nold MF. Failure of Interferon-gamma to induce the anti-inflammatory Interleukin-18 Binding Protein in familial hemophagocytosis. 
Plos One, 5(1):e8663, 2010.

15. Taneja D, Thompson J, Wilson P, Brandewie K, Schaefer L, Mitchell B, Tannock LR. Reversibility of renal injury with cholesterol lowering in hyperlipidemic diabetic mice. J Lipid Res, 51: 1464-1470, 2010

16. Bingold TM, Ziesche E, Scheller B, Sadik CD, Franck K, Just L, Sartorius S, Wahrmann M, Wissing H, Zwissler B, Pfeilschifter J, and Mühl H. Interleukin-22 detected in patients with abdominal sepsis. Shock, 34(4): 337-340, 2010

17. Kiss E, Popovic ZV, Bedke J, Adams J, Bonrouhi M, Babelova A, Schmidt C, Edenhofer F, Zschiedrich I, Domhan S, Abdollahi A, Schaefer L, Gretz N, Porubsky S, Gröne HJ. Peroxisome Proliferator-Activated Receptor (PPAR){gamma} Can Inhibit Chronic Renal Allograft Damage. Am J Pathol, 176: 2150-2162, 2010

18. Schwalm S, Pfeilschifter J, and Andrea Huwiler. Sphingosine kinase 1 is critically involved in nitric oxide-mediated human endothelial cell migration and tube formation. Brit J Pharmacol, 160(7): 1641-1651; 2010

19. Schürmann C, Seitz O, Sader R, Pfeilschifter J, Goren I, and Frank S. Role of wound macrophages in skin flap loss or survival in an experimental diabetes model. Br J Surgery, 97(9): 1437-1451, 2010

20. Pfeilschifter W, Czech B, Hoffmann BP, Sujak M, Kahles T, Steinmetz H, Neumann-Haefelin T, and Pfeilschifter J.Pyrrolidine Dithiocarbamate activates p38 MAPK and protects brain endothelial cells from apoptosis: A mechanism for the protective effect in stroke? Neurochem Res, 35(9): 1391-1401, 2010

21. Puneet P, Yap CT, Wong L, Yulin L, Koh DR, Moochhala S, Pfeilschifter J, Huwiler A, and Melendez AJ. SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis. Science, 328 (5983), 1290-1294, 2010

22. Iozzo RV and Schaefer L. Proteoglycan roles in health and disease: Novel regulatory signaling mechanisms evoked by the small leucine-rich-proteoglycans. FEBS J, 277: 3864-3875, 2010

23. Bachmann M, Horn K, Rudloff I, Goren I, Holdener M, Christen U, Darsow N, Hunfeld KP, Koehl U, Kind P, Pfeilschifter J, Kraiczy P, and Mühl H. Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and IL-1.PLoS Pathogens, 14;6(10):e1001144, 2010

24. Scheiermann P, Seeger FH, and Breitkreutz R. Ultrasound-guided central venous access in adults and children: Procedure and pathological findings. Anaesthesist (german), 59(1): 53-61, 2010

25. Christen U, Holdener M, and Hintermann E. Cytochrome P450 2D6 as a model antigen. Dig Dis, 28(1): 80-85, 2010

26. Christen U. Enterovirus infection of human beta-cells activates dendritic cells and triggers innate antiviral responses: are enteroviruses convicted now? Diabetes, 59(5): 1126-1128, 2010

27. Jung O, Jansen F, Mieth A, Barbosa-Sicard E, Pliquett RU, Babelova A, Morisseau C, Hwang SH, Tsai C, Hammock BD, Schaefer L, Geisslinger G, Amann K, and Brandes RP. Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease. PLoS One, 5(8): oii: e11979, 2010

28. Sender LY, Gibbert K, Suezer Y, Radeke HH, Kalinke U, and Waibler Z. CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals. Mol Immunol, 47(6): 1255-1261, 2010

29. Ren S, Xin C, Pfeilschifter J, and Huwiler A. A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation. Cell Physiol Biochem, 26(1): 97-104, 2010

30. Förster A, Emmler T, Schwalm S, Ebadi M, Meyer zu Heringdorf D, Nieuwenhuis B, Kleuser B, Huwiler A, and Pfeilschifter J. Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate. Kidney Int, 77(10): 870-879, 2010

31. Ungerer C, Doberstein K, Bürger C, Hardt K, Boehncke WH, Böhm B, Pfeilschifter J, Dummer R, Mihic-Probst D, and Gutwein P. ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma. Biochem Biophys Res Comm, 401(3): 363-369, 2010

32. Hintermann E, Bayer M, Pfeilschifter JM, Luster AD, and Christen U. CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation. J Autoimmun, 35(4): 424-435, 2010

33. Moreth K, Brodbeck R, Babelova A, Gretz N, Spieker T, Zeng-Brouwers J, Pfeilschifter J, Young M, Schaefer RM, Schaefer L. The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephrithis. J Clin Invest, 120: doi:10.1172/JCI42213, 120(12): 4251-72, 2010

34. Dinarello C, Arend W, Sims J, Smith D, Blumberg H, O'Neill L, Goldbach-Mansky R, Pizarro T, Hoffman H, Bufler P, Nold M, Ghezzi P, Mantovani A, Garlanda C, Boraschi D, Rubartelli A, Netea M, van der Meer J, Joosten L, Mandrup-Poulsen T, Donath M, Lewis E, Pfeilschifter J, Martin M, Kracht M, Muehl H, Novick D, Lukic M, Conti B, Solinger A, Peyman K, van de Veerdonk F, Gabel C. IL-1 family nomenclature. Nat Immunol. , 11(11):973, 2010

1. Scheiermann P, Hoegl S, Revermann M, Ahluwalia D, Zander J, Boost KA, Nguyen T, Zwissler B, Mühl H, and Hofstetter C. Cecal ligation and incision. An acute model of severe sepsis in rats. J Surg Res, 151(1), 132-137, 2009

2. Mulders AC, Mathy MJ, Meyer Zu Heringdorf D, Ter Braak M, Hajji N, Olthof DC, Michel MC, Alewijnse AE, and Peters SL. Activation of sphingosine kinase by muscarinic receptors enhances NO-mediated and attenuates EDHF-meiated vasorelaxation. Basic Res Cardiol, 104(1): 50-59, 2009

3. Schürmann C, Seitz O, Klein C, Sader R, Pfeilschifter J, Mühl H, Goren I, and Frank S. Tight spatial and temporal control in dynamic basal to distal migration of epithelial inflammatory responses and infiltration of cytoprotective macrophages determine healing skin flap transplants in mice. Ann Surg, 249(3): 519-534, 2009

4. König B, Koch A, Spielmann J, Hilgenfeld C, Hirche F, Stangl GI, and Eder K. Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1. Eur J Pharmacol, 605(1-3): 23-30, 2009

5. Hoegl S, Boost KA, Czerwonka H, Dolfen A, Scheiermann P, Mühl H, Zwissler B, and Hofstetter C. Inhaled IL-10 reduces biotrauma and mortality in a model of ventilator-induced lung injury. Resp Med, 103(3): 463-470, 2009

6. Schramme A, Oh ST, Stark A, Tilgen W, Gutwein P, and Reichrath J. The disintegrin-metalloproteinases ADAM10, ADAM12 and ADAM17 are upregulated in invading peripheral tumor cells of basal cell carcinomas. J Cutan Pathol, 36(4): 395-401, 2009

7. Goren I, Müller E, Schiefelbein D, Gutwein P, Seitz O, Pfeilschifter J, and Frank S. Akt1 controls insulin-driven VEGF biosysnthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice. J Invest Dermatol, 129(3): 752-764, 2009

8. Gutwein P, Schramme A, Sinke N, Abdel-Bakky MS, Voss B, Obermüller N, Doberstein K, Koziolek M, Fritzsche F, Johannsen M, Jung K, Schaider H, Altevogt P, Ludwig A, Kristiansen G, and Pfeilschifter J. Tumoral CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients. European Journal of Cancer, 45(3): 478-489, 2009

9. Giegold O, Ludwig RJ, Hardt K, Will J, Schön MP, Oostingh GJ, Pfeilschifter JM, Boehncke WH, and Radeke HH. Computer-aided analysis of cell interactions under dynamic flow conditions. Exp Dermatol, 18: 238-245, 2009

10. Jespersen C, Doller A, Akool ES, Bachmann M, Müller R, Gutwein P, Mühl H, Pfeilschifter J, and Eberhardt W.Molecular mechanisms of nitric oxide-dependend inhibition of TPA-induced matrix metalloproteinase-9 (MMP-9) in MCF-7 cells. J Cell Physiol, 219(2): 276-287, 2009

11. Alban S, Ludwig RJ, Bendas G, Schön MP, Oostingh GJ, Radeke HH, Fritzsche J, Pfeilschifter J, Kaufmann R, and Boehncke WH. PS3, a semisynthetic beta-1,3-glucan sulfate, diminishes contacthypersensitivity responses through inhibition of L- and P-Selectin functions. J Invest Dermatol, 129(5): 1192-1202, 2009

12. Doller A, Gauer S, Sobkowiak E, Geiger H, Pfeilschifter J, and Eberhardt W. Angiotensin II enhances renal PAI-1 and COX-2 expression posttranscriptionally by activating the mRNA-stabilizing factor HuR. implications for hypertensive nephrosclerosis. Am J Pathol, 174(4): 1252-1263, 2009

13. Gutwein P, Schramme A, Voss B, Abdel-Bakky MS, Doberstein K, Ludwig A, Altevogt P, Hansmann ML, Moch H, Kristiansen G, and Pfeilschifter J. Downregulation of Junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma. Biochem Biophys Res Commun, 380(2): 387-391, 2009

14. Königshoff M, Wilhelm J, Jahn A, Amarie OV, Kramer M, Kitowska K, Wilhelm A, Bohle RM, Obert M, Traupe H, Seeger W, Rose F, Fink L, Schaefer L, Günther A, and Eickelberg O. WISP, a matricellular protein of the CCN family, is a novel mediator of pulmonary fibtrosis. J Clin Invest, 119: 772-787, 2009

15. Richter C, Juan MH, Will J, Brandes RP, Kalinke U, Akira S, Pfeilschifter JM, Hultqvist M, Holmdahl R, and Radeke HH. Ncf1 provides a reactive oxygen species-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells. J Immunol, 182(7): 4183-4891, 2009

16. Appel S, Vetterkind S, Koplin A, Maertens B, Boosen M, and Preuss U. EFP1 is an ER stress-induced glycoprotein which interacts with the pro-apoptotic protein Par-4. Cell Health and Cytoskeleton, 1: 1-16, 2009

17. Nieuwenhuis B, Lüth A, Chun J, Huwiler A, Pfeilschifter J, Schäfer-Korting M, and Kleuser B. Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone. J Mol Med, 87: 645-657, 2009

18. Gutwein P, Abdel-Bakky MS, Schramme A, Doberstein K, Kämpfer-Kolb N, Amann K, Hauser IA, Obermüller N, Bartel C, Abdel-Aziz A, El Sayed E, and Pfeilschifter J. CXCL16 is expressed in podocytes and acts as a scavenger receptor for oxidized LDL. Am J Pathol, 2009 (in press)

19. Riedle S, Kiefel H, Gast D, Bondong S, Wolterink S, Gutwein P, and Altevogt P. Nuclear translocation and signaling of L1-CAM in human carcinoma cells requiresADAM10 and presenilin/ secretase activity. Biochem J, 2009 (in press)

20. Goren I, Allmann N, Yogev N, Schürmann C, Linke A, Holdener M, Waisman A, Pfeilschifter J, and Frank S. A transgenic mouse model of inducible macrophage depletion: effects of diphteria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic and contractive processes. Am J Pathol, 2009 (in press)

21. Scheiermann P, Ahluwalia D, Hoegl S, Dolfen A, Revermann M, Zwissler B, Mühl H, Boost KA, and Hofstetter C. Effects of intravenous and inhaled levosimendan in severe rodent sepsis. Intensive Care Med, 2009 (in press)

22. Ziesché E, Scheiermann P, Bachmann M, Sadik CD, Hofstetter C, Zwissler B, Pfeilschifter J, and Mühl H. Dexamethasone suppresses IL-22 associated with bacterial infection in vitro and in vivo. Clin Exp Immunol, 2009 (in press)

23. Sadik CD, Bachmann M, Pfeilschifter J, and Mühl H. Activation of interferon regulatory factor-3 via Toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA. Nucleic Acids Res, 37(15):5041-56, 2009

24. Arafa HM, Hemeida RA, Hassan MI, Abdel-Wahab MH, Badary OA, and Hamada FM. Basic acetyl-1-carnitine ameliorates caerulein-induced acute pancreatitis in rats. Basic Clin Pharmacol, 2009 (in press)

25 Dreieicher E, Beck KF, Lazaroski S, Boosen M, Tsalastra-Greul W, Beck M, Fleming I, Schäfer L, and Pfeilschifter J. Nitric oxide inhibits glomerular TGB-beta signaling via SMOC-1. J Am Soc Nephrol, 2009 (in press)

26. Osipova-Goldberg HI, Turchanowal LV, Adler B, and Pfeilschifter JM. H2O2 inhibits BCR-dependent immediate early induction of EBV genes in Burkitts lymphoma cells. Free Rad Bio Med, 2009 (in press)

27. Ren S, Babelova A, Moreth K, Xin C, Eberhardt W, Doller A, Pavenstädt H, Schaefer L, Pfeilschifter J, and Huwiler A. The TGF-beta-induced CTGF expression is under suppressive control of sphingosine kinase-1 in podocytes in vitro and in vivo. Kidney Int, 2009 (in press)

28. Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Gröne HJ, and Schaefer L. Biglycan: a danger signal that activates the NLRP3 inflammasome via Toll-like and P2X receptors. J Biol Chem, 2009 (in press)

29. Gutgesell A, Wen G, König B, Koch A, Spielmann J, Stangl GI, Eder K, and Ringseis R. Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells. Biochim Biophys Acta, 2009 (in press)

30. Boosen M, Vetterkind S, Kubicek J, Scheidtmann KH, Illenberger S, and Preuss U. Par-4 is an essential downstream target of Dlk in Dlk/Par-4-mediated apoptosis. Mol Biol Cell, 2009 (in press)

31. Czech B, Pfeilschifter W, Omrani NM, Strobel MA, Kahles T, Neumann-Haefelin T, Rami A, Huwiler A, and 
Pfeilschifter J. The immunomodulatory sphingosine 1-phosphate analoge FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. Biochem Biophys Res Commun, 389(2): 251-256, 2009

32. Zhang G, Breuer M, Förster A, Egger-Adam D, and Wodarz A. Mars, a Drosophila protein related to vertebrate HURP, is required for the attachment of centrosomes to the mitotic spindle during syncytial nucler divisions. J Cell Sci., 122(pt4): 535-545, 2009

33. Zhu X, De Laurentis W, Leang K, Herrmann J, Ihlefeld K, van Pee KH, and Naismith JH. Structural insights into the regioselectivity in the enzymatic chlorination of trypthphan. J Mol Biol, 391(1): 74-85, 2009

34. Rückrich T, Kraus M, Gogel J, Beck A, Ovaa H, Verdoes M, Overkleeft HS, Kalbacher H, and Driessen C.Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells. Leukemia, 23(6): 1098-1105, 2009

35. Grillet N, Xiong W, Reynolds A, Kazmierczak P, Sato T, Lillo C, Dumont RA, Hintermann E, Sczaniecka A, Schwander M, Williams D, Kachar B, Gillespie PG, and Müller U. Harmonin mutations cause mechanotransduction defects in cochlear hair cells. Neuron, 62(3): 375-387, 2009

36. Merline R, Schaefer R, and Schaefer L. The matricellular functions of small leucine-rich proteoglycans (SLRPs). J Cell Com Signal, 3: 323-335, 2009

37. Merline R, Lazaroski S, Babelova A, Tsalastra-Greul W, Pfeilschifter J, Schlüter KD, Günther A, Iozzo RV, Schaefer RM, and Schaefer L. Decorin deficiency in diabetic mice: Aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear infiltration. J Physiol Pharmacol 60, Suppl 4, 2009

38. ter Braak M, Danneberg K, Lichte K, Liphardt K, Ktistakis NT, Pitson SM, Hla T, Jakobs KH, and Meyer zu Heringdorf D. Galphaq-mediated plasma membrane translocation of sphingosine kinase-1and cross-activation of S1P receptors. Biochim Biophys Acta, 1791(5): 357-370, 2009

39. Pushparaj PN, Manikandan J, Tay HK, H`ng SC, Kumar S, Pfeilschifter J, Huwiler A, and Melendez AJ. Sphingosine Kinase 1 is pivotal for FcepsilonRI-mediated mast cell signaling and functional responses in vitro and in vivo. J Immunol, 183(1): 221-227, 2009

40. Osman B, Doller A, Akool ES, Holdener M, Hintermann E, Pfeilschifter J, and Eberhardt W. Rapamycin induces the TGFb/Smad signaling cascade in renal mesangial cells upstream of mTOR. Cell Signal, 21(12): 1806-1817, 2009

41. Ludwig RJ, Hardt K, Hatting M, Bistrian R, Diehl S, Radeke HH, Podda M, Schön MP, Kaufmann R, Henschler R, Pfeilschifter JM, Santoso S, Boehncke WH. Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin. Immunology, 128(2): 196-205, 2009

42. Pfeilschifter W, Neumann-Haefelin T, Hattingen E, and Singer OC. Kortikale Venenthrombose nach diagnostischer Lumbalpunktion. Der Nervenarzt, 80(10):1219-1221, German, 2009

43. Balah A, Akool ES, Bachmann M, Pfeilschifter J, and Mühl H. The dsRNA mimetic poly(I:C) and IL-18 synergize for IFNgamma and TNFalpha expression. Biochem Biophys Res Commun, 389(4): 628-633, 2009

44. Bachmann M, Paulukat J, Pfeilschifter J, and Mühl H. Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level. J Cell Mol Med, 13(8b): 1987-1994, 2009
45. Christen U, Hintermann E, and Jaeckel E. New animal models for autoimmune hepatitis. Semin Liver Dis, 29(3): 262-272, 2009

46. Horwitz MS, Efrat S, Christen U, von Herrath MG, and Oldstone MB. Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes. Proc Natl Acad Sci USA, 106(46): 19450-19454

47. Wicker S, Pfeilschifter JM, and Gottschalk, R. Gesundheit von Studierenden der Medizin. Zentralblatt für Arbeitsmedizin, 8: 234-241, German, 2009

48. Huwiler A and Pfeilschifter J. Lipids as targets for novel anti-inflammatory therapies. Pharmacol Ther, 124(1):96-112, 2009

49. Boost KA, Leipold T, Scheiermann P, Hoegl S, Sadik CD, Hofstetter C, and Zwissler B. Sevoflurane and isoflurane decrease TNF-alpha-induced gene expression in human monocytic THP-1 cells: potential role of intracellular IkappaBalpha regulation. Int J Mol Med. 23(5): 665-71, 2009

50. Bergthaler A, Flatz L, Verschoor A, Hegazy AN, Holdener M, Fink K, Eschli B, Merkler D, Sommerstein R, Horvath E, Fernandez M, Fitsche A, Senn BM, Verbeek JS, Odermatt B, Siegrist CA, Pinschewer DD. Impaired antibody response causes persistence of prototypic T cell-contained virus. PLoS Biol. 7(4): e1000080, 2009

51. Gutwein P, Abdel-Bakky MS, Doberstein K, Schramme A, Beckmann J, Schäfer L, Amann K, Doller A, Kämpfer-Kolb N, Abdel-Aziz A, El Sayed E, and Pfeilschifter J. CXCL16 and oxLDL are induced in the onset of diabetic nephropathy. J Cell Mol Med, 13(9B), 3809-38254, 2009

52. Schramme A, Oh ST, Tilgen W, Gutwein P, and Reichrath J. Overexpression of CXCL16 in lesional psoriatic skin. Dermato-Endocrinology, 1(2):114-118, 2009

Publications 2008

1. Lichte K, Rossi R, Danneberg K, ter Braak M, Kürschner U, Jakobs KH, Kleuser B, and Meyer zu Heringdorf D.Lysophospholipid receptor-mediated calcium signaling in human keratinocytes. J Invest Dermatol, 1, 1-12, 2008

2. Fink K, Zellweger R, Weber J, Manjarrez-Orduno N, Holdener M, Senn BM, Hemgartner H, Zinkernagel RM, and Macpherson AJ. Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies. Eur J Immunol, 38: 90-101, 2008

3. Daniel C, Sartory NA, Zahn N, Radeke HH, and Stein J. Immunomodulatory treatment of TNBS colitis with calcitriol is associated with a change of Th1/Th17 to Th2 and regulatory T- cell profile. J Pharmacol Exp Ther, 324(1): 23-33, 2008

4. Cevikbas F, Schaefer L, Uhlig P, RobenekH, Theilmeier G, Echtermeyer F, and Bruckner P. Unilateral nephrectomy leads to upregulation of syndecan-2 and TGF-beta mediated glomerulosclerosis in syndecan-4 deficient mice. Matrix Biol, 27(1): 42-52, 2008

5. Johann AM, Weigert A, Eberhardt W, Kuhn A-M, Barra V, von Knethen A, Pfeilschifter J, and Brüne B. Apoptotic cell derived S1P promotes HuR-dependent COX-2 mRNA stabilization and protein expression. J Immunol, 180(2): 1239-1248, 2008

6. Conen A, Weisser M, Orasch JC, Battagay M, Trampuz A, Frei R, Christen S, Heim D, Gratwohl A, and Flückiger U.Candida krusei - a serious complication in patients with hematological malignancies: successful treatment with caspofungin. Transpl Infect Dis, 10(1): 66-70, 2008

7. Hoegl S, Boost KA, Flondor M, Scheiermann P, Muhl H, Pfeilschifter J, Zwissler B, Hofstetter C. Short-term exposure to high-pressure ventilation leads to pulmonary biotrauma and systemic inflammation in the rat. Int J Mol Med, 21(4): 513-519, 2008

8. Rubant SA, Ludwig RJ. Diehl S, Hardt K, Kaufmann R. Pfeilschifter JM, and Boehncke WH. Dimethylfumarate reduces leukocyte rolling in vivo through modulation of adhesion molecule expression. J Invest Dermatol, 128(2): 326-331, 2008

9. Westermann D, Mersmann J, Melchior A, Petrik C, Freudenberger T, Lettau O, Schaefer L, Lüllmann-Rauch R, Jacoby C, Schrader J, Brand-Herrmann SM, Young MF, Levkau B, Babba H, Unger T, Zacharowski K, Tschöpe C, and Fischer JW.Biglycan is required for adaptive remodelling after myocardial infarction. Circulation, 117(10): 1269-1276, 2008

10. Schwalm S, Graf F, Römer I, Bubnova S, Pfeilschifter J, and Huwiler A. Sphingosine kinase-1 is a hypoxia-regulated gene that regulates migration of human endothelial cells. Biochem Biophys Res Commun, 368(4): 1020-1025, 2008

11. Doller A, Akool ES, Huwiler A, Müller R, Radeke HH, Pfeilschifter J, and Eberhardt W. Posttranslational modification of the AU-rich element binding protein HuR by PKCdelta elicits angiotensin II-induced stabilization and nuclear export of COX-2 mRNA. Mol Cell Biol, 28(8): 2608-2625, 2008

12. Poleganov MA, Bachmann M, Pfeilschifter J, and Mühl H. Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: Critical role of two kappaB binding sites in the human EBI3 promotor. Mol Immunol, 45(10): 2869-2880, 2008

13. Koch A, König B, Stangl GI, Eder K. PPAR alpha mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis. Exp Biol Med (Maywood), 233(3): 356-365, 2008

14. König B, Koch A, Giggel K, Dordschbal B, Eder K, Stangl GI. Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha. Biochim Biophys Acta, 1780(6): 899-904, 2008

15. Lastres-Becker, I., Brodesser, S., Lütjohann, D., Azizov, M., Buchmann, J., Hintermann, E., Sandhoff, K., Schürmann, A., Nowock, J., Auburger, G. Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice. Hum Mol Genet. 15: 1465-1481, 2008

16. Janot L, Secher T, Torres D, Maillet I, Pfeilschifter J, Quesniaux VFJ, Landmann, R, Ryffel B, and Erard F. CD14 with Toll-like receptor 2 contributes to recognition and control of Listeria monocytogenes infection. J Infect Dis, 2008 (in press)

17. Huwiler A and Pfeilschifter J. New player on the center stage: sphingosine 1-phosphate and its receptors as drug targets. Biochem Pharmacol, 2008 (in press)

18. Schramme A, Abdel-Bakky MS, Kämpfer-Kolb N, Pfeilschifter J, and Gutwein P. The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells. Biochem Biophys Res Commun, 2008 (in press)

19. Schramme A, Abdel-Bakky MS, Gutwein P, Obermüller N, Baer PC, Hauser IA, Ludwig A, Gauer S, Schäfer L, Sobkowiak E, Altevogt P, Koziolek M, Kiss E, Gröne HJ, Tikkanen R, Goren I, Radeke HH, and Pfeilschifter J.Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney. Kidney Int, 2008 (in press)

20. Oh ST, Schramme A, Stark A, Tilgen W, Gutwein P, and Reichrath J. Overexpression of ADAM10 and ADAM12 in lesional psoriatic skin. Br J Dermatol, 2008 (in press)

21. Schiefelbein D, Goren I, Fißlthaler B, Schmidt H, Geisslinger G, Pfeilschifter J, Frank S. Biphasic regulation of HMG CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses. J Biol Chem, 2008 (in press)

22. Sadik CD, Hunfeld KP, Bachmann M, Kraiczy P, Eberhardt W, Brade V, Pfeilschifter J, and Mühl H. Systematic analysis highlights the key role of TLR2/NFkappaB/MAP kinase signaling for IL-8 induction by macrophage-like THP-1 cells under influence of B.burgdorferi lysates. Int J Biochem Cell Biol, 2008 (in press)

23. Schaefer L, Iozzo RV. Biological functions of the Small leucine-rich proteoglycans: From genetics to signal transduction. J Biol Chem, 2008 (in press)

24. Holdener, M., Hintermann, E., Bayer, M., Rhode, A., Rodrigo, E., Hintereder, G., Johnson, E.F., Gonzalez, F.J., Pfeilschifter, J., Manns, M.P., von Herrath, M.G., and Christen, U. Breaking tolerance to the natural human liver autoantigen Cytochrome P450 2D6 by virus infection. J Exp Med, 2008 (in press)

25. Akool ES, Doller A, Babelova A, Tsalastra W, Moreth K, Schaefer L, Pfeilschifter J, and Eberhardt W. Molecular mechanisms of TGFb-receptor-triggered signalingn cascades rapidly induced by the calcineurin inhibitors cyclosphorine and FK506. J Immunol, 181(4): 2831-2845, 2008 

26. Goren I, Müller E, Pfeilschifter, and Frank S. Thr308 determines Akt1 nuclear localization in insulin-stimulated keratinocytes. Biochem Biophys Res Commun, 372(1): 103-107, 2008

27. Duning K, Schurek EM, Schlüter M, Bayer M, Reinhardt HC, Schwab A, Schaefer L, Benzing T, Saleem MA, Kremerskothen J, Weide T, and Pavenstädt H. KIBRA is involved in cell polarity, migration and adhesion of podocytes. J Am Soc Nephrol, 19: 1891-1903, 2008

28. Doller A, Pfeilschifter J, and Eberhardt, W. Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR. Cell Signal, 20(12): 2165-2173, 2008

29. Boost KA, Sadik CD, Bachmann M, Zwissler B, Pfeilschifter J, and Mühl H. IFNgamma impairs release of IL-8 by IL-1beta stimulated A549 lung carcinoma cells. BMC Cancer, 8: 265, 2008

30. Schielfelbein D, Seitz O, Goren I, Dißmann JP, Schmidt H, Bachmann M, Sader R, Geisslinger G, Pfeilschifter J, and Frank S. Keratinocyte-derived VEGF biosynthesis represents a pleiotropic side effect of PPARgamma agonist troglitazone but not rosiglitazone and involves activation of p38 MAPK: implications for diabetes-impaired skin repair. Mol Pharmacol, 74(4): 952-963, 2008

31. Hofmann LP, Ren S, Schwalm S, Pfeilschifter J, and Huwiler A. Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner. Biol Chem, 389: 1399-1407, 2008

32. Wiesemann E, Deb M, Hemmer B, Radeke HH, and Windhagen A. Early identification of interferon-beta responders by ex vivo testing in patients with multiple sclerosis. Clin Immunol, 128(3): 306-313, 2008

33. Meyer zu Heringdorf. Lysophospholoipids. Encyclopedia of Molecular Pharmacology; Offermanns S,Rosenthal W (Eds); 2nd Edition, Springer-Verlag Heidelberg, 2008

1. Keller C, Rivera GiP, Tölle M, van der Giet M, Chun J, Radeke HH, Schäfer-Korting M, and Kleuser B. Immunmodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signalling. Am J Pathol, 170(1): 281-292, 2007

2. Waibler Z, Kalinke U, Will J, Herrero San Juan M, Pfeilschifter JM, and Radeke HH. TLR-ligand stimulated interleukin-23 subunit expression and assembly is regulated differentially in murine plasmacytoid and myeloid dendritic cells. Mol Immunol, 44(7): 1483-1489, 2007

3. Moreth K, Riester D, Hildmann C, Hempel R, Wegener D, Schober A, Schwienhorst A. An active site tyrosine residue is essential for amidohydrolase but not for esterase activity of a class 2 histone deacetylase-like bacterial enzyme. Biochem J, 401: 659-665, 2007

4. Bachmann M, Dragoi C, Poleganov MA, Pfeilschifter J, Mühl H. Interleukin-18 directly activates T-bet expression and function via p38-MAP kinase and NFkappaB in AML-derived Pre-dendritic KG-1 cells. Mol Cancer Ther, 6(2): 723-731, 2007

5. Daniel C, Sartory NA, Zahn N, Geisslinger G, Radeke HH, and Stein J. FTY720 ameriolates Th1-mediated colitis in mice by directly affecting the functional activity od CD4+CD25+ regulatory T-cells. J Immunol, 178(4): 2458-2468, 2007

6. Ramos-Lopez E, Brück P, Jansen T, Pfeilschifter JM, Radeke HH, and Badenhoop K. CYP2R1-, CYP27B1- and CYP24-mRNA expression in German type 1 diabetes patients. J Steroid Biochem Mol Biol, 103(3-5): 807-810, 2007

7. Buchhaupt M, Pfeifer C, and Entian KD. Analysis of 2`-O-methylated nucleosides and pseudouridines in ribosomal RNAs using DNAzymes. Anal Biochem, 361(1): 102-108, 2007

8. Schaefer L, Tsalastra W, Babelova A, Baliova M, Minneruo J, Sorokin L, Gröne HJ, Reinhardt DP, Pfeilschifter J, Iozzo RV, and Schaefer RM. Decorin-mediated regulation of fibrillin-1 in the kidney involves IGF-1 receptor and mTOR. Am J Pathol, 170(1): 301-315, 2007

9. Bedke J, Kiss E, Schaefer L, Behnes CL, Bonrouhi M, Gretz N, Horuk R, Diedrichs-Moehring M, Wildner G, Nelson PJ, and Gröne HJ. Beneficial effects of CCR1 blockade on the progression of chronic renal allograft-damage. Am J Transplant, 7(3): 527-537, 2007

10. Klawitter S, Hofmann LP, Pfeilschifter J, and Huwiler A. Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity. Br J Pharmacol, 150(3): 225-257, 2007

11. Stoeck A, Gast D, Sanderson MP, Issa Y, Gutwein P, Altevogt P. L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. Gynecol Oncol, 104(2): 461-469, 2007

12. Doller A, Akool ES, Müller R, Gutwein P. Kurowski C, Pfeilschifter J, and Eberhardt W. Molecular Mechanisms of cyclosporin A inhibition of the cytokine-induced matrix metalloproteinase-9 (MMP-9) in glomerular mesangial cells. J Am Soc Nephrol, 18(2): 581-592, 2007

13. Zhang C, Wenger T, Mattern J, Ilea S, Frey C, Gutwein P, Altevogt P., Bodenmuller W, Gassler N, Schnabel PA, Dienemann H, Marme A, Hohenfellner M, Haferkamp A, Pfitzenmaier J, Grone HJ, Kolb A, Buchler P, Buchler M, Friess H, Rittgen W, Edler L, Debatin KM, Krammer PH, Rutz HP, and Herr I. Clinical and Mechanistic Aspects of Glucocorticoid-Induced chemotherapy resitance in the majority of solid tumors. Cancer Biol Ther, 6(2): 278-287, 2007

14. Boost KA, Hoegl S, Hofstetter C, Flondor M, Stegewerth K, Platacis I, Pfeilschifter J, Mühl H, and Zwissler B. Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on Il-1b, IL-18 and downstream pro-inflammatory parameters as detected in rat ecdotoxaemia. Intensive care Med, 33(5): 863-871, 2007

15. Eberhardt W, Doller A, Akool ES, Pfeilschifter J. Modulation of mRNA stability as a novel therapeutic approach. Pharmacology & Therapeutics, 114(1): 56-73, 2007

16. Doller A, Huwiler A, Müller R, Radeke HH, Pfeilschifter J, and Eberhardt W. PKCalpha-dependend phosphorylation of the mRNA stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2. Mol Biol Cell, 18(6): 2137-2148, 2007

17. Ziesché E, Bachmann M, Kleinert H, Pfeilschifter J, Mühl H. The IL-22/STAT3 pathway potentiates expression of iNOS in human colon carcinoma cells. J Biol Chem, 282(22): 16006-16015, 2007

18. Döll F, Pfeilschifter J, and Huwiler A. Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration. Endocrine-Related Cancer, 14(2): 325-335, 2007

19. Daniel C, Sartory NA, Zahn N, Schmidt R, Geisslinger G, Radeke HH, and Stein J. FTY720 ameliorates oxazolone-coliltis in mice by directly affecting T helper 2 functions. Mol Immunol, 44(13): 3305-3316, 2007

20. Eberhardt W and Pfeilschifter J. Nitric oxide and vascular remodeling: Spotlight on the kidney. Kidney Int Suppl, 106: S9-S16, 2007

21. Schacke W, Beck KF, Pfeilschifter J, and Hattenbach LO. Expression of ubiquitin carboxy-terminal hydrolase-11 in photocoagulated human retinal pigment epithelial cells. Curr Eye Res, 32(4): 367-372, 2007

22. Goren I, Müller E, Schiefelbein D, Christen U, Pfeilschifter J, Mühl H, and Frank S. Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages. J Invest Derm, 127(9):2259-2267, 2007

23. Luchtefeld M, Bandlow N, Tietge UJ, Grote K, Pfeilschifter J, Kaszkin M, Beck S, Drexler H, and Schieffer B.Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A(2)-dependent lipid peroxidation. Atherosclerosis, 194(1), 62-70, 2007

24. Gauer S, Sichler O, Obermüller N, Holzmann Y, Kiss E, Sobkowiak E, Pfeilschifter J, Geiger H, Mühl H, Hauser IA. IL-18 is expressed in the intercalated cell of human kidney. Kidney Int, 72(9): 1081-1087, 2007

25. Behrens F, Himsel A, Rehart S, Stanczyk J, Beutel B, Zimmermann SY, Köhl U, Moeller B, Gay S, Kaltwasser JP, Pfeilschifter JM, and Radeke HH. Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis. Annals of the Rheumatic Diseases, 66:1151-1156, 2007

26. Buchhaupt M, Kotter P, and Entian KD. Mutations in the nucleolar proteins Tma23 and Nop6 suppress the malfunction of the Nep1 protein. FEMS Yeats Res, 7(6): 771-781, 2007

27. Schaefer L, Schaefer RM. A primer on iron therapy. Nephrol Dial Transplant, 22(9): 2429-2431, 2007

28. Ulrich S, Huwiler A, Loitsch S, Schmidt H, and Stein JM. De novo ceramide biosysnthesis is associated with resveratrol-induced inhibition or ornithine decarboxylase activity. Biochem Pharmacol, 74(2): 281-289, 2007

29. Xin C, Ren S, Eberhardt W, Pfeilschifter J, and Huwiler A. Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta - induced prostaglandin E2 formation. J Lipd Res, 48(9), 1985-1996, 2007

30. Dwir O, Grabovski V, Pasvolsky R, Manevich E, Shamri R, Gutwein P, Feigelson SW, Altevogt P, and Alon R.Membranal cholestreol is not required for L-selectin adhesiveness in primary lymphocytes but controls a chemokine-induced destabilization of L-selectin rolling adhesions. J Immunol, 179(2): 1030-1038, 2007

31. Nold M, Nold-Petry C, Fischer D, Richter B, Blaheta R, Pfeilschifter J, Mühl H, Schranz D, and Veldman A. Activated protein C downregulates p38 mitogen-activated protein kinase and improves clinical parameters in an in vivo model of septic shock. Thrombosis and Haemostatsis, 98(5), 1118-1126, 2007

32. Keller S, Rupp C, Stoeck A, Runz S, Fogel M, Lugert S, Hager HD, Abdel-Bakky MS, Gutwein P, and Altevogt P. CD24 is a marker of exosomes secreted into urine and amniotic fluid. Kidney Int, 72(9), 1095-1102, 2007

33. Hintermann E and Christen U. Viral infection - a cure for type 1 diabetes? Cur Med Chem, 14: 2048-2052, 2007

34. Christen U and Hintermann E. Dual role of CXCL10 as conductor of cellular traficking during typ 1 diabetes. Int J Biomed Sci, 3: 86-92, 2007

35. Christen U, Holdener M, and Hintermann E. Animal models for autoimmune hepatitis. Autoimmune Rev, 6: 306-311, 2007

36. Christen U. Chemokines as drug targets intype 1 diabetes. Endocr Metab Immun Disord Drug Targets (Curr Drug Targezs), 7: 7-12, 2007

37. Martinic MM, Juedes AE, Bresson D, Homann D, Skak K, Huber C, Ling E, Ejrnares M, Wolfe T, Togher L, Christen U, and von Herrath, MG. Minimal impact of a de-novo expressed B-cell autoantigen on spontaneous diabetes development in NOD mice. Diabetes, 56: 1059-1068, 2007

38. Schneider D, Liaw L, Daniel C, Athanasopoulus AN, Herrmann M, Preissner KT, Nawroth PP, and Chavakis T. Inhibition of breasr cancer cell adhesion and bone metastasis by the extracellular adherence protein of Staphylococcus aureus. Biochem Biophys Res Com, 357(1), 282-288, 2007

39. Daniel C, Schroeder O, Zahn N, Steinhilber D, and Stein J. The TGFbeta-Smad 3-signalling pathway is involved in butyrate-mediated Vitamin D receptor expression. J Cell Biochem, 102(6), 1420-1431, 2007

40. Xin C, Ren S, Eberhardt W, Pfeilschifter J, and Huwiler A. FTY720 suppresses Interleukin -1beta induced secretory phospholipase A2 expression in renal mesangial cells by a transriptional mechanism. Br J Pharmacol, 150, 943-950, 2007

41. König B, Koch A, Spielmann J, Hilgenfeld C, Stangl GI, and Eder K. Activation of PPARalpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2. Biochem Pharmacol, 73(14), 574-585, 2007

42. Koch A, König B, Spielmann J, Leitner A, Stangl, GI and Eder K. Thermally oxidized oil increases the expression of insulin-induced genes and inhibits activation of sterol regulatory elememt-binding protein-2 in rat liver. J Nutr, 137(9), 2018-2023, 2007

43. Koch A, König B, Luci S, Stangl, GI, and Eder K. Dietary oxidzed fat up regulates the expression of organic cation transporters in liver and small intestine and alters carnitine concentrations in liver, muscle and plasma of rats. Br J Nutr, 98(5), 882-889, 2007

44. Hofstetter C, Boost KA, Flondor M, Basagan-Mogol E, Betz C, Homann M, Mühl H, Pfeilschifter J, Zwissler B. Anti-inflammatory effects of sevoflurane and mild hypothermia in endotoxemic rats. Acta Anaesthesiol Scand, 51(7), 893-899, 2007

45. Boost KA, Flondor M, Hofstetter C, Platacis I, Stegewerth K, Hoegl S, Nquyen T, Mühl H, Zwissler B. The beta-adrenoceptor antagonist propranolol counteracts anti-inflammatory effects of isoflurane in rat endotoxemia. Acta Anaesthesiol Scand, 51(7), 900-908, 2007

46. Hofstetter C, Boost KA, Hoegl S, Flondor M. Scheller B, Mühl H, Pfeilschifter J, Zwissler B. Norepinephrine and vasopressin counteract anti-inflammatory effects of isoflurane in endotoxemic rats. Int J Mol Med, 20(4), 597-604, 2007

47. Alemany R, van Koppen CJ, Danneberg K, Ter Braak M, and Meyer Zu Heringdorf D. Regulation and functional roles of sphingosine kinases. Naunyn Schmiedebergs Arch Pharmacol, 374(5-6), 413-428, 2007

48. Meyer Zu Heringdorf D, Jakobs KH. Renal mesangial cells: moving on sphingosine kinase-1. Br J Pharmacol, 150(3), 255-257, 2007

49. Meyer Zu Heringdorf D, Jakobs KH. Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism. Biochim Biophys Acta, 1768(4), 923-940, 2007

50. Mewes KR, Raus M, Bernd A, Zöller NN, Sättler A, and Graf R. Elastin expression in a newly developed full thickness skin equivalent. Skin Pharmacol Physiol, 20, 85-95, 2007

51. Poleganov MA, Pfeilschifter J, and Mühl H. Expanding extracellular zinc beyond levels reflecting the albumin-bound plasma zinc pool potentiates the capability of IL-1beta, IL-18, and IL-12 to act as IFNgamma-inducing factors on PBMC. J Interferon Cytokine Res, 27(12), 997-1002, 2007

52. Huwiler A and Zamgemeister-Wittke U. Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy. Crit Rev Oncol Hemat, 63(2): 150-159, 2007

1. Bachmann M, Kosan C, Xing PX, Montenarh M, Hoffmann I, Möröy T. The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C. Int J Biochem Cell Biol, 38(3): 430-443, 2006

2. Zhang C, Marme A, Wenger T, Gutwein P, Edler L, Rittgen W, Debatin KM, Altevogt P, Mattern J, Herr I. Glucocorticoid-mediated inhibition of chemotherapy in ovarian carcinomas. 
Int J Oncol, 28(2): 551-558, 2006

3. Bachmann M, Horn K, Poleganov MA, Paulukat J, Nold M, Pfeilschifter J, Mühl H. Interleukin-18 secretion and Th1-like cytokine responses in human peripheral blood mononuclear cells under the influence of the toll-like receptor-5 ligand flagellin. Cellular Microbiology, 8(2), 289-300, 2006

4. Plesková M, Beck KF, Behrens MH, Huwiler A, Fichtlscherer B, Wingerter O,Brandes RP, Mülsch A, Pfeilschifter J. Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells. FASEB J, 20(1), 139-141, 2006

5. Xin C, Ren S, Eberhardt W, Pfeilschifter J, Huwiler A. The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signaling cascade and upregulate connective tissue growth factor (CTGF) and collagen type IV expression in renal mesangial cells. Br J Pharmacol., 147(2):164-74, 2006

6. Goren I, Linke A, Müller E, Pfeilschifter J, Frank, S. The Suppressor of Cytokine Signaling (SOCS)-3 is upregulated in impaired skin repair: Implications for keratinocyte proliferation. J Invest Dermatol.,126(2): 477-85, 2006

7. Goren I, Müller E, Pfeilschifter J, Frank, S. Severely impaired insulin signaling in chronic wounds of diabetic ob/ob mice: a potential role of TNFalpha. Am J Pathol, 168(3):765-77, 2006

8. Goren I, Kämpfer H, Müller E, Schiefelbein D, Pfeilschifter J, Frank, S. Oncostatin M expression is functionally connected to neutrophils in the early inflammatory phase of skin repair: implications for normal and diabetis-impaired wounds. J Invest Dermatol.,126(3): 628-37, 2006

9. Ludwig RJ, Werner RJ, Winker W, Boehncke WH, Wolter M, Kaufmann R. Chronic venous insufficiency – a potential trigger for localized scleroderma J Eur Acad Dermatol Venereol., 20(1): 96-9, 2006

10. Stoeck A, Keller S, Riedle S, Sanderson MP, Runz S, Lenaour F, Gutwein P, Ludwig A, Rubinstein E, Altevogt P. A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem J, 393(Pt 3): 609-18, 2006

11. Stirnweiss J, Valkova C, Ziesche E, Drube S, Liebmann C. Muscarinic M2 receptors mediate transactivation of EGF receptor through Fyn kinase and without matrix metalloproteases. Cell Signal. 18(8): 1338-49, 2006

12. Stoeck A, Schlich S, Issa J, Gschwend V, Wenger T, Herr I, Marme A, Bourbie S, Altevogt P, and Gutwein P. L1 on ovarian carcinoma cells is a binding partner for Neuropilin-1 on mesothelial cells. Cancer Letters, 239(2): 212-26, 2006

13. Mühl H, Pfeilschifter J. Controlling the cytokine storm by insulin: Glycogen Synthase Kinase-3 as a target in systemic inflammation. Critical Care Medicine, 34(5): 1567-9, 2006

14. Huwiler A, Döll F, Ren S, Klawitter S, Greening A, Römer I, Bubnova S, Reinsberg L, Pfeilschifter J. Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 in a PKC-alpha dependend mechanism. Biochim. Biophys. Acta - Molecular and Cell Biology of Lipids, 1761(3): 367-76, 2006

15. Boost KA, Hofstetter C, Flondor M, Betz C, Homann M, Pfeilschifter J, Mühl H, Zwissler B. Desflurane differentially affects the release of proinflammatory cytokines in plasma and bronchoalveolar fluid of endotoxemic rats. Int J Mol Med, 17(6): 1139-44, 2006

16. Ludwig RJ, Alban S, Bistrian R, Boehncke WH, Henschler R, Kaufmann R, Gille J. The ability of different forms of heparins to suppress P-selectin function in vitro correlates to their inhibitory capacity on blood-borne metastasis in vivo. 
Thromb Haemost, 95(3): 535-40, 2006

17. Rubant S, Ludwig RJ, Pfeffer J, Schulze-Johann P, Kaufmann R, Pfeilschifter JM, Boehncke WH, Radeke HH.Eukaryotic expression of the broad-spectrum chemokine receptor antagonist vMIP-II and its effects on T-cell function in vitro and in vivo. Exp Dermatol. 15(8): 634-42, 2006

18. Fritzsche J , Alban S, Ludwig RJ, Rubant S, Boehncke WH, Schumacher G, Bendas G. The influence of various structural parameters of semisynthetic sulfated polysaccharides on the P-selectin inhibition capacity. Biochemical Pharmacology, 72(4): 474-85, 2006

19. Wienrich BG, Oostingh GJ, Ludwig RJ, Enders S, Harms G, Tauber R, Krahn T, Kramer B, Boehncke WH, and Schön MP. reply to "Efomycine M: an inhibitor of selections ?". Nat Med, 12(8); 873-874, 2006

20. Beck S, Beck G, Ostendorf T, Floege J, Lambeau G, Nevalainen T, Radeke HH, Gurrieri S, Haas U, Thorwart B, Pfeilschifter J, Kaszkin M. Upregulation of group IB secreted phospholipase A2 and its M-type receptor in rat anti-Thy-1 glomerulonephritis. Kidney Int. 70: 1251-1260, 2006

21. Huwiler A, Pfeilschifter J. Altering the Sphingosine-1-phosphate/Ceramide Balance: A Promising Approach for Tumor Therapy? Curr Pharmaceut Design, 12(35): 4625-4635, 2006

22. Dequiedt F, Martin M, von Blume J, Vertommen D, Lecomte E, Mari N, Heinen MF, Bachmann M, Twizere JC, Huang C, Rider MH, Piwnica-Worms H, Seufferlein T, Kettmann R. A new role for hPar-1 kinases, EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. Mol Cell Biol, 26(19); 7086-7102, 2006

23. Hartner A, Schaefer L, Porst M, Cordasic N, Gabriel N, Klanke B, Reinhardt DP, and Hilgers KF. Role of fibrillin-1 for hypertensive and diabetic glomerular disease. Am J Physiol Renal Physiol 290: F1329-F1336, 2006

24. Kurylowicz A, Ramos-Lopez E, Bednarczuk T, and Badenhoop K. Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves`disease and the vitamin D status in a Polish population study. Exp Clin Endocrinol Diabetes, 114(6): 329-325, 2006

25. Ramos-Lopez E, Ghebru S, van Autreve J, Aminkeng F, Herwig J, Seifried E, Seidl C, van der Auwera B, and Badenhoop K. Neither an intronic CA repeat within the CD48 gene nor the HERV-K18 polymorphisms are associated with type 1 diabetes. Tissue Antigens, 68(2): 147-152, 2006

26. Lieb B, Dimitrova K, Kang HS, Braun S, Gebauer W, Martin A, Hanelt B, Saenz SA, Adema CM, and Markl J. Red blood with blue-blood ancestry: intriguing structure of a snail hemoglobin. Proc Natl Acad Sci USA, 103(32): 12011-12016, 2006

27. Huwiler A and Pfeilschifter J. Hypoxia and lipid signaling. Biol. Chem., 387 (10-11): 1321-1328, 2006

28. Ludwig RJ, Alban S, Boehncke WH. Structural requirements of modified glycosaminoglycans to exert polyvalent anti-inflammatory activities 
Mini-Rev Med Chem, 6(9): 1009-1023, 2006

29. Rüster B, Gottig S, Ludwig RJ, Bistrian R, Müller S, Seifried E, Gille J, and Henschler R. Mesenchymal stem cells (MSC) display coordinated rolling and adhesion behaviour on endothelial cells. Blood, 108(12): 3938-3944, 2006

30. Ramos-Lopez E, Jansen T, Ivaskevicius V, Kahles H, Klepzig C, Oldenburg J, Badenhoop K. Protection from type 1 diabetes by vitamin D receptor haplotypes. Ann N Y Acad Sci, 1079: 327-334, 2006

31. Daniel C, Radeke HH, Sartory NA, Zuegel U, Steinmeyer A, and Stein J. The new low calcemic vitamin D analogue 22-ene-25-oxa-vitamin D ameliorates Th1-mediated colitis in mice. J Pharmacol Experimental Therapeutics, 319(2): 622-631, 2006

32. Ludwig RJ, Schindewolf M, Utikal J, Lindhoff-Last E, and Boencke WH. Management of cutanenous heparin hypersensitivity reactions. Thromb Haemost, 96(5): 611-617, 2006

33. Buchhaupt M, Meyer B, Kotter P, Entian KD. Genetic evidence for 18S rRNA binding and an Rpr19p assembly function of yeast nucleolar protein Nep1p. Mol Genet Genomics, 276(3): 273-284, 2006

34. Hankeln T, Klawitter S, Kramer M, Burmester T. Molecular characterization of hemoglobin from the honeybee Apis mellifera. J Insect Physiol, 52(7): 701-710, 2006

35. Burmester T, Storf J, Hasenjager A, Klawitter S, Hankeln T. The hemoglobin genes of Drosophila. FEBS J, 273(3): 468-480, 2006

36. Fujinami RS, von Herrath MG, Christen U, Whitton JL. Molecular mimicry, bystander activation, or viral persistence: Infections and autoimmune disease. Clin Microbiol Rev, 19(1): 80-94, 2006

37. Ejrnaes M, von Herrath MG, Christen U. Cure of chronic viral infection and virus-induced type-1 diabetes by neutralizing antibodies. Clin Dev Immunol, 13(2-4): 337-347, 2006

38. Barral AM, Thomas HE, Ling EM, Darwiche R, Rodrigo E, Christen U, Ejrnaes M, Wolfe T, Kay TW, von Herrath MG.SOCS-1 protects from virally-induced CD8 T-cell mediated type 1 diabetes. J Autoimmun, 27(3), 166-173, 2006

39. von Allmen N, Christen S, Forster U, Gottstein B, Welle M, Muller N. Acute trchinellosis increases susceptibilityto Giardia lamblia infection in the mouse model. Parasitology, 133(Pt2), 139-149, 2006

40. Fink, K, Lang KS, Manjarrez-Orduno N, Junt T, Senn BM, Holdener M, Akira S, Zinkernagel RM, and Hengartner H.Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses. Eur J Immunol, 36(8), 2094-2105, 2006

41. Brück P, Vilches CN, Ramos-Lopez E, Barboza QO, Ancer RJ, and Flores GJP. Expresion del Her2-Neu en el adenocarcinoma ductal de la glandula mamaria: correlacion con parametros istopatologicos y expresion de receptores estrogenicos en pacientes mexicanas. Ginecol Obstet Mex, 74(10), 516-522, 2006

1. Kautz K, Schwarz M, Radeke HH. Interference with MCP-1 gene expression by vector generated triple helix-forming RNA oligonucleotides. 
CMLS, Cell Mol Life Sci, 62:001-015, 2005

2. Djordjevic T, Belaiba RS, Bonello S, Pfeilschifter J, Hess J, Görlach A. Human Urotensin II Is a Novel Activator of NADPH Oxidase in Human Pulmonary Artery Smooth Muscle Cells. Arterioscler Thromb Vasc Biol., 25(3): 519-525, 2005

3. Vlachojannis GJ, Scholz-Pedretti K, Fierlbeck W, Geiger H, Pfeilschifter J, Kaszkin M. Enhanced expression of group IIA secreted phospholipase A2 by elevated glucose levels in cytokine-stimulated rat mesangial cells and in kidneys of diabetic rats. 
Clin Nephrol, 63 (5): 356-367, 2005

4. Gunia S, Behrens MH, Stosiek P. Mycobacterial spindle cell pseudotumour (MSP) of the nasal septum clinically mimicking Kaposi's sarcoma: A case report. Rhinology, 43(1): 70-71, 2005

5. Bachmann M, Moroy T. The serine/threonine kinase Pim-1. Int J Biochem Cell Biol, 37(4): 726-30, 2005

6. Haas U, Podda M, Behne M, Gurrieri S, Alonso A, Fürstenberger G, Pfeilschifter J, Lambeau G, Gelb MH, Kaszkin M. Characterization and differentiation-dependent regulation of secreted phospholipases A2 in human keratinocytes and healthy and psoriatic human skin. J Invest Dermatol 124: 204 –211, 2005

7. Kämpfer H, Schmidt R, Geisslinger G, Pfeilschifter J, Frank S. Wound inflammation in diabetic ob/ob mice: functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing. Diabetes, 54(5): 1543-1551, 2005

8. Hoth A, Johannisson R, Syed Ali S, Schulze J, Siegers C-P. Cytotoxicity of organotin compounds in different cultured cell lines. Toxicol. Industr. Health, 131-136, 2005

9. Beck KF, Güder G, Schaefer L, Pleskova M, Babelova A, Behrens MH, Mihalik D, Beck M, Schaefer RM, Pfeilschifter, J.Nitric oxide upregulates induction of plateled-derived growth factor receptor a expression in rat renal mesangial cells and in anti-Thy-1 glomerulonephritis. J Am Soc Nephrol, 16(7): 1948-1957, 2005

10. Hofstetter C, Flondor M, Boost KA, Koehler P, Bosmann M, Pfeilschifter J, Zwissler B, Mühl H. A brief exposure to Isoflurane (50 seconds) significantly impacts on plasma cytokine levels in endotoxemic rats. International Immunopharmacology, 5(10): 1519-1522, 2005

11. Eberhardt W, Kilz T, Akool El-Sayed, Müller R, Pfeilschifter J. Dissociated Glucocorticoids equipotently inhibit cytokine- and cAMP-induced matrix degrading proteases in rat mesangial cells. Biochem Pharmacol, 70(3): 433-445. 2005

12. Calderwood JW, Williams JM, Morgan MB, Nash GB, Savage CO. ANCA induces beta2 integrin and CXC chemokine-dependend neutrophil-endothelial cell interactions that mimic those of highly cytokine-activated endothelium. J Leukoc Biol. 77: 33-43, 2005

13. Daniel C, Schlauch T, Zugel U, Steinmeyer A, Radeke HH, Steinhilber D, Stein J. 22-ene-25-oxa-vitamin D: a new vitamin D analogue with profound immunosuppressive capacities. Eur J Clin Invest 35(5): 343-349, 2005

14. Hauser IA, Spiegler S, Kiss E, Gauer S, Sichler O, Scheuermann EH, Ackermann H, Pfeilschifter JM, Geiger H, Grone HJ, Radeke HH. Prediction of acute renal allograft rejection by urinary monokine induced by IFNgamma (MIG). J Am Soc Nephrol. 16(6): 1849-1858, 2005

15. Radeke HH, von Wenckstern H, Stoidtner K, Sauer B, Hammer S, Kleuser B. Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine langerhans cell line XS52. J Immunol. 174(5): 2778-2786, 2005

16. Hofstetter C, Flondor M, Hoegl S, Mühl H, Zwissler B. Interleukin-10 aerosol reduces proinflammatory mediators in bronchoalveolar fluid of endotoxemic rat. Crit Care Med, 33(10): 2317-2322, 2005

17. Petry C, Huwiler A, Eberhardt W, Kaszkin M, and Pfeilschifter J. Hypoxia increases group IIA phospholipase A2 expression under inflammatory conditions in rat renal mesangial cells. J Am Soc Nephrol, 16(10): 2897-2905, 2005

18. Christen U, von Herrath MG. Infections and autoimmunity--good or bad? J Immunol. 174(12): 7481-7486, 2005

19. Ejrnaes M, Videbaek N, Christen U, Cooke A, and Michelsen BK, von Herrath M. Different diabetogenic potential of autoaggressive CD8+ clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic activity, or homing characteristics. J Immunol. 174(5): 2746-2755, 2005

20. Hintermann E, Yang N, O'Sullivan D, Higgins JM, and Quaranta V. Integrin alpha6beta4-erbB2 complex inhibits haptotaxis by up-regulating E-cadherin cell-cell junctions in keratinocytes. J Biol Chem. 280(9): 8004-8015, 2005

21. Gutwein P, Stoeck A, Riedle S, Gast D, Runz S, Condon TP, Marme A, Phong MC, Linderkamp O, Skorokhod A, and Altevogt P. Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells. Clin Cancer Res. 11(7): 2492-2501, 2005

22. Gast D, Riedle S, Riedle S, Schabath H, Schlich S, Schneider A, Issa Y, Stoeck A, Fogel M, Joumaa S, Wenger T, Herr I, Gutwein P, and Altevogt P. L1 augments cell migration and tumor growth but not beta3 integrin expression in ovarian carcinomas. Int J Cancer 115(4): 658-665, 2005

23. Ludwig RJ, Zollner TM, Santoso S, Hardt K, Gille J, Baatz H, Schulze Johann P, Pfeffer J, Radeke HH, Kaufmann R, Boehncke WH, and Podda M. Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation. J Invest Dermatol, 125(5): 969-976, 2005

24. Radeke HH, Ludwig RJ, and Boehncke WH. Experimental approaches to lymphocyte migration in dermatology in vitro and in vivo. Experimental Dermatology 14(9): 641-666, 2005

25. Calderwood JW and Radeke HH. Chapter 4: In vitro techniques to investigate lymphocyte extravasation. In: "Lymphocyte homing to the skin” Boehncke WH (Ed.), CRC Press, Boca Raton, FL, USA, 2005

26. Rhode A, Pauza M, Barral AM, Rodrigo E, Oldstone MB, von Herrath MG, Christen U. Islet-specific expression of IP10 (CXCL10) targets lymphocytes to the pancreas and accelerate type 1 diabetes. J Immunol. 175(6): 3516-3524, 2005

27. Hattenbach LO, Beck KF, Pfeilschifter J, Koch F, Ohrloff C, Schacke W. Pigment-Epithelium-Derived Factor is upregulated in photocoagulated human retinal pigment epithelial cells. Ophthalmic Res. 37 (6): 341-346, 2005

28. Akool ES, Doller A, Müller R, Gutwein P, Xin C, Huwiler A, Pfeilschifter J, Eberhardt W. Nitric oxide induces Timp-1 expression by activating the TGFß-Smad signaling pathway. J Biol Chem., 280 (47): 39403-39416, 2005

29. Haase H, Alvarez J, Petzhold D, Doller A, Behlke J, Erdmann J, Hetzer R, Regitz-Zagrosek V, Vassort G, Morano I.Ahnak is critical for cardiac Ca(v)1.2 calcium channel function and its [beta]-adrenergic regulation. FASEB J. 19 (14): 1969-1977, 2005

30. Christen U, von Herrath MG. Viruses as initiators, accelerators or terminators of autoimmunity?- A question of time and location of infection. Autoimmune Liver Disease (Falk Symposium 142), 2005

31. Pfeilschifter J, Beck KF. Chapter 15, pages: 327-340: Nitric oxide and gene expression. In " Nitric oxide cell signaling and gene expression", Cadenas E and Lamas S (Eds.), Taylor and Francis group, Boca Raton, Fl, USA, 2005

32. Ren S, Xin, C, Beck KF, Saleem MA, Mathieson P, Pavenstädt H, Pfeilschifter J, Huwiler A. PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism. Biochim. Biophys. Res. Commun., 338(4): 1818-24, 2005

33. Döll F, Pfeilschifter J, Huwiler A. The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7. Biochim. Biophys. Acta, 1738(1-3): 72-81, 2005

34. Wahab NA, Schaefer L, Weston BS, Yiannikouris O, Wright A, Babelova A, Schaefer R, Mason RM. Glomerular expression of thrombospondin-1., transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli. Diabetologia, 48: 2650-2660, 2005

35. Schaefer L, Babelova A, Kiss E, Hausser HJ, Baliova M, Krzyzankova M, Marsche G, Young MF, Mihalik D, Gotte M, Malle E, Schaefer RM, Grone HJ. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest, 115, 2223-2233, 2005

36. Heeg MH, Koziolek MJ, Vasko R, Schaefer L, Sharma K, Muller GA, Strutz F. The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway. Kidney Int, 68(1): 96-109, 2005

37. Seidler DG, Schaefer L, Robenek H, Iozzo RV, Kresse H, Schönherr E. A physiologic three-dimensional cell culture system to investigate the role of decorin in matrix organisation and cell survival. Biochem Biophys Res Commun, 15, 332(4): 1162-1170, 2005

38. Schönherr E, Sunderkötter C, Iozzo R, Schaefer L. Decorin, a novel player in the insulin-like growth factor system. J Biol Chem, 280(16): 15767-15772, 2005

1. Petry C, Fritz G, Pfeilschifter J, and Huwiler A. Inhibition of Rho modulates cytokine- induced prostaglandin E2 formation in renal mesangial cells. Biochem Biophys Acta1636:0108-118, 2004

2. Chatterjee PK, Patel NSA, Cuzzocrea S, Brown PAJ, Stewart KN, Mota-Filipe H, Britti D, Eberhardt W, Pfeilschifter J, Thiemermann C: The cyclopentenone prostaglandin 15-deoxy-delta12, 14-prostaglandin J2 ameliorates ischemic acute renal failure. Cardiovasculare Research 61:630-643, 2004

3. Kaszkin M, Beck KF, Eberhardt W, and Pfeilschifter J. Unravelling Green Tea's Mechanisms of Action: More than Meets the Eye. Mol Pharmacol 65: 15-17, 2004

4. Hocher B, Schwarz A, Slowinski T, Bachmann S, Pfeilschifter J, Neumayer HH, Bauer C: In-vivo interaction of nitric oxide and endothelin. Journal of Hypertension (22) 111-119, 2004

5. Rodriguez I, Holloschi A, Kaszkin M, Cheng H, Kabsch K, Hafner M, Alonso A: Activation of phospholipase C-gamma1 in human keratinocytes by hyperosmolar shock without enzyme phosphorylation. Arch Dermatol Res 295(11):490-497, 2004

6. Kaszkin M, Beck KF, Koch E, Erdelmeier C, Kusch S, Pfeilschifter J, Loew D: Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects. Phytomedicine, 11:585-595, 2004

7. Blume C, Sabuda-Widemann D, Pfeilschifter J, Plum J, Schror K, Grabensee B, Beck KF: Cerivastatin inhibits proliferation of interleukin-1beta-induced rat mesangial cells by enhanced formation of nitric oxide. Eur J Pharmacol 485(1-3):1-10, 2004

8. Hellmuth M, Paulukat J, Ninic R, Pfeilschifter J, Mühl H: Nitric oxide differentially regulates pro- and anti-angiogenic markers in DLD-1 colon carcinoma cells. FEBS Lett 563(1-3):98-102, 2004

9. Boissel JP, Ohly D, Bros M, Gödtel-Armbrust U, Förstermann U, Frank S: The neuronal nitric oxide synthase is upregulated in mouse skin repair and in responce to epidermal growth factor in human HaCaT keratinocytes. J Invest Dermatol 123(1):132-139, 2004

10. Zampetaki A, Mitsialis SA, Pfeilschifter J, Kourembanas S: Hypoxia induces macrophage inflammatory protein-2 (MIP-2) gene expression in murine macrophages via NF-kB. FASEB J 18(10):1090-1092, 2004

11. Gunia S, Behrens MH, Stosiek P: A rare course of Whipple`s disease with atypical cardiac manifestation. Acta Pathologica, Microbiologica, et Immunologica Scandinavica 112(3): 222-224, 2004

12. Fichtlescherer S, Kaszkin M, Breuer S, Dimmler S, Zeiher AM. Elevated secretory group II phospholipase A2 serum activity is assiciated with impaired endothelial vasodilator function in patients with coronary artery disease. Clin Sci (Lond) 106: 511-517, 2004

13. Xin C, Ren S, Kleuser B, Shabahang S, Eberhardt W, Radeke H, Schäfer-Korting M, Pfeilschifter J and Huwiler A.Sphingosine-1-phosphate cross-activates the Smad-signaling cascade and mimics TGFb-induced cell responses. J Biol Chem 279(34):35255-35262, 2004

14. Huwiler A, Xin C, Brust AK, Briner VA, Pfeilschifter J. Differential binding of ceramide to MEKK1 in glomerular endothelial and mesangial cells. Biochim Biophys Acta 1636:159-168, 2004

15. Huwiler A, Pfeilschifter J. Erythropoietin is more than just a promoter of erythropoiesis. 
J Am Soc Nephrol. 15(8):2240-2241, 2004

16. Mühl, H, Pfeilschifter J. Interleukin-18 bioactivity: a novel target for immunopharmacological anti-inflammatory intervention. Eur J Pharmacol 500(1-3): 63-71, 2004

17. Kahlina K, Goren I, Pfeilschifter J, Frank S. p68 dead box RNA helicase expression in 
keratinocytes: Regulation, nuclear localisation, and functional connection to proliferation and 
VEGF gene expression. J Biol Chem 279(43):44872-44882, 2004

18. Xin C, Ren S, Pfeilschifter J, Huwiler A. Heterologous desensitivation of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells. 
Br J Pharmacol, 143(5):581-589, 2004

19. Schäfer L, Ren S, Schäfer RM, Mihalik D, Babelova A, Huwiler A, Pfeilschifter J. Nephrin expression is increased in anti-Thy1.1-induced glomerulonephritis in rats. 
Biochem Biophys Res Commun, 5;324(1):247-254, 2004

20. Mühl H, Paulukat J, Höfler S, Hellmuth M, Franzen R, Pfeilschifter J. The HIV protease inhibitor Ritonavir synergizes with butyrate for induction of apoptotic cell death and mediates expression of heme oxygenase-1 in DLD-1 colon carcinoma cells. Br J Pharmacol, 143(7):890-898, 2004

21. Sun M, Kong L, Wang X, Holmes C, Gao Q, Zhang G-R, Pfeilschifter J, Goldstein DS, Geller A. Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter-2 from a helper virus-free HSV-1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease. Human Gene Ther, 15:1177-1196, 2004

22. Bachmann M, Hennemann H, Xing PX, Hoffmann I, Moroy T. The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint. 
J Biol Chem 12;279(46):48319-48328, 2004

23. Potapov EV, Ignatenko S, Nasseri BA, Loebe M, Harke C, Bettmann M, Doller A, Regitz-Zagrosek V, Hetzer R. Clinical significance of PlA polymorphism of platelet GP IIb/IIIa receptors during long-term VAD support. Ann Thorac Surg 77(3):869-874, 2004

24. Fähling M, Perlewitz A, Doller A, Thiele BJ. Regulation of collagen prolyl4-hydroxylase and matrix metalloproteinases in fibrosarcoma cells by hypoxia. 
Comp Biochem Physiol C Toxicol Pharmacol 139(1-3):119-126, 2004

25. Itoh K, Cheng L, Kamei Y, Fushiki S, Kamiguchi H, Gutwein P, Stoeck A, Arnold B, Altevogt P, Lemmon V. Brain development in mice lacking L1-L1 homophilic adhesion. 
J Cell Biol 165(1):145-154, 2004

26. Thiele BJ, Doller A, Kähne T, Pregla R, Hetzer R, Regitz-Zagrosek V. RNA-Binding Proteins Heterogeneous Nuclear Ribonucleoprotein A1, E1, and K Are Involved in Post-Transcriptional Control of Collagen I and III Synthesis. Circ Res 95(11):1058-1066, 2004

27. Kaszkin M, Schneider B, and Loew D. Kasuistik: Ein hochdosierter Harpagophytum- Spezialextrakt als Phytoanalgetikum und -antiphlogistikum zur Remissionserhaltung des Morbus Crohn. Ärztezeitschrift fuer Naturheilverfahren (2):102-106 2004

28. Kaszkin M, Pfeilschifter J, and Loew D. Harpagophytum-Extrakte als sinnvolle Phytoanalgetika/-antiphlogistika? Schweizer Medizinische Zeitschrift für Phytotherapie (4): 4-8, 2004

29. Jiang X, Multhaupt H, Chan E, Schaefer L, Schaefer RM, Couchman JR. Essential contribution of tumor-derived perlecan to epidermal tumor growth and angiogenesis. J Histochem Cytochem, 52(12): 1575-1590, 2004

30. Schönherr E, Sunderkötter C, Schaefer L, Thanos S, Grassel S, Oldberg A, Iozzo RV, Young MF, Kresse H. Decorin deficiency leads to impaired angiogenesis in injured mouse cornea. J Vasc Res, 41(6): 499-508, 2004

31. Schaefer L, Mihalik D, Babelova A, Krzyzankova M, Grone HJ, Iozzo RV, Young MF, Seidler DG, Lin G, Reinhardt DP, Schaefer RM. Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury. Am J Pathol, 65(2): 383-396, 2004

32. Yung S, Hausser H, Thomas G, Schaefer L, Kresse H, Davies M. Catabolism of newly synthesized decorin in vitro by human peritoneal mesothelial cells. Perit Dial Int, 24(2): 147-155, 2004 

1. Beck GCh, Hermes WC, Yard BA, Kaszkin M, von Zabern D, Schulte J, Haak M, Prem K, Krimsky W, van Ackern K, van der Woude FJ, and Yedgar S. Amelioration of endotoxin-induced sepsis in rats by membrane anchored lipid conjugates. Crit Care Med 31, 2015-2021, 2003

2. Kämpfer H, Bräutigam L, Geisslinger G, Pfeilschifter J, and Frank S. Cyclooxygenase-1-coupled prostaglandin biosynthesis constitues an essential prerequisite for skin repair. J Invest Dermatol 120, 880-890, 2003

3. Beck GCh, Yard BA, Schulte J, Haak M, van Ackern K, van der Woude FJ, and Kaszkin M. Secreted phospholipases A2 induce the expression of chemokines in microvascular endothelium. Biochem Biophys Res Commun. 300, 731-737, 2003

4. Heese K., Beck KF, Behrens MH, Pluss K, Fierlbeck W, Huwiler A, Mühl H, Geiger H, Otten U, and Pfeilschifter J. Effects of high glucose on cytokine-induced nerve growth factor (NGF) expression in rat renal mesangial cells. Biochem Pharmacol 65, 293-301, 2003

5. Uhlenbrock K, Huber J, Ardati A, BuschAE and Kostenis E Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. Cell Physiol Biochem 13, 75-84, 2003

6. Bruch-Gerharz D, Schnorr O, Suschek C, Beck KF, Pfeilschifter J, Ruzicka T, and Kolb-Bachofen V. Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocytes hyperproliferation. Am J Pathol 162, 203-211, 2003

7. Pfeilschifter J, Eberhardt W, Beck KF, and Huwiler A. Redox signaling in mesangial cells. 
Nephron 93, 23-26, 2003

8. Madsen JT, Jansen P, Hesslinger C, Meyer M, Zimmer J and Gramsbergen JB. Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of 
1-methyl-4-phenylpyridinium in nigral slice cultures. J Neurochem 85(1):214-23, 2003

9. Möller B, Paulukat J, Nold M, Behrens MH, Kukoc-Zivojnov N, Kaltwasser JP, Pfeilschifter J, and Mühl H. Interferon-g induces expression of interleukin-18 binding protein in fibroblast-like synoviocytes. Rheumatology, 42, 442-445, 2003

10. Rölz W, Xin C, Ren S, Pfeilschifter J, and Huwiler A. Interleukin-1b inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide. Br. J. Pharmacol 138, 461-468, 2003

11. Nold M, Goede A, Eberhardt W, Pfeilschifter J, and Mühl H. IL-18 initiates release of matrix metalloproteinase-9 from peripheral blood mononuclear cells without affecting tissue inhibitor of matrix metalloproteinases-1: Supression by TNFa blockage and modulation by IL-10. Naunyn-Schmiedeberg's Archives of Pharmacology 367, 68-75, 2003

12. Goren I, Pfeilschifter J, and Frank S. Determination of leptin signaling pathways in human 
and murine keratinocytes. Biochem Biophys Res Commun. 303, 1080-1085, 2003

13. Gurrieri S, Fürstenberger G, Schadow A, Haas U, Singer AG, Ghomashchi F, Pfeilschifter J, Lambeau G, Gelb MH, and Kaszkin M. Differentiation-dependent regulation of secreted phospholipases A2 in murine epidermis. J Invest Dermatol 121:156-164, 2003

14. Nold M, Hauser IA, Höfler S, Goede A, Eberhardt W, Ditting T, Geiger H, Pfeilschifter J, and Mühl H. IL-18BPa:Fc cooperates with immunosuppressive drugs in human whole blood. Biochem Pharmacol 66, 505-510, 2003

15. Huwiler A, Ren Shuyu, Holthöfer Harry, Pavenstädt H, and Pfeilschifter J. Inflammtory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes. Biochem Biophys Res Commun. 305, 136-142, 2003

16. Failer BU, Aschrafi A, Schmalzing G, and Zimmermann H. Determination of native oligomeric state and substrate specificity of rat NTPDase1 and NTPDase2 after heterologous expression in Xenopus oocytes. Eur J Biochem 271, 1802-1809, 2003

17. Akool ES, Kleinert H, Hamada FMA, Abdelwahab MH, Förstermann U, Pfeilschifter J, and Eberhardt W. Nitric oxide increases the decay of MMP-9 mRNA by inhibiting the expression of mRNA stabilizing factor HuR. Mol Cell Biol 23, 4901-4916, 2003

18. Schaefer L, Beck KF, Raslik I, Walpen S, Mihalik D, Micegova M, Macakova K, Schonherr E, Seidler DG, Varga G, Schaefer RM, Kresse H, and Pfeilschifter J. Biglycan, a nitric oxide-regulated gene, affects adhesion, growth and survival of mesangial cells. J Biol Chem 278, 26227-26237, 2003

19. Deja M, Busch T, Bachmann S, Riskowski K, Campean V, Wiedmann B, Schwabe M, Hell B, Pfeilschifter J, Falke KJ, and Lewandowski K. Reduced nitric oxide in sinus epithelium of patients with radiologic maxillary sinusitis and sepsis. Am J Respir Crit Care Med 168(3):281-6, 2003

20. Gauer S, Hartner A, Hauser IA, Fierlbeck W, Eberhardt W, and Geiger H. Differential regulation of osteopontin expression in the clipped and nonclipped kidney of two-kidney, one-clip hypertensive rats. Am J Hypertens 16, 214-222, 2003

21. Mühl H and Pfeilschifter J. Anti-inflammatory properties of pro-inflammatory Interferon-g. Int Immunopharmacol 3, 1247-1255, 2003

22. Beck S, Lambeau G, Scholz-Pedretti K, Gelb MH, Janssen MJW, Edwards SH, Wilton DC, Pfeilschifter J, and Kaszkin M. Potentiation of TNFalpha-induced sPLA2-IIA expression in mesangial cells by an autocrine loop involving secreted phospholipase A2 and PPARalpha activation. J Biol Chem 278(32): 29799-29812, 2003

23. Huwiler A and Pfeilschifter J. Nitric oxide signalling with a special focus on lipid derived 
mediators. Biol Chem 384(10-11):1379-89, 2003

24. Kämpfer H, Pfeilschifter J, and Frank S. Expression and activity of arginase isoenzymes 
during normal and diabetes-impaired skin repair. J Invest Dermatol 121(6):1544-51, 2003

25. Aschrafi A, Franzen R, Shabahang S, Fabbro D, Pfeilschifter J, and Huwiler A. Ceramide induces translocation of protein kinase C-ato the Golgi compartment of human embryonic kidney cells by interacting with C2 domain. Biochim Biophys Acta 1634(1-2):30-9, 2003

26. Goren I, Kämpfer H, Podda M, Pfeilschifter J, and Frank S. Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators. Diabetes 52(11):2821-32, 2003

27. Mühl H and Pfeilschifter J. Endothelial nitric oxide synthase: a determinant of TNFa production by human monocytes/macrophages. Biochem Biophys Res Commun 310, 677-680, 2003

28. Kaszkin M and Loew D. Comparability of herbal medicinal products. Journal of the European Society of Regulatory AffairsMay/June Vol. 10, No. 3, 2003

29. Mühl H, Höfler S, and Pfeilschifter J. Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide. Eur J Pharmacol 482(1-3):325-8, 2003

30. Huwiler A, Akool El-S, Aschrafi A, Hamada FM, Pfeilschifter J, and Eberhardt W. ATP potentiates IL-1b-induced MMP-9 expression in mesangial cells via recruitment of the ELAV protein HuR. J Biol Chem 278(51):51758-69, 2003

31. Pfeilschifter J, Eberhardt W, and Huwiler A. Nitric Oxide and Mechanisms of Redox Signaling. J Am Soc Nephrol 14, 237-240, 2003

32. Fichtlescherer S, Kaszkin M, Breuer S, Dimmler S, and Zeiher AM. Elevated secretory group II phospholipase A2 serum activity is assiciated with impaired endothelial vasodilator function in patients with coronary artery disease. Clin Sci (Lond) 2003 Dec 19

33. El-Gayar S, Thuring-Nahler H, Pfeilschifter J, Rollinghoff M, and Bogdan C. Translational control of inducible nitric oxide synthase by IL-13 and arginine availability in inflammatory macrophages. J Immunol 171, 4561-4568, 2003

34. Leckel K, Beecken WD, Jonas D, Oppermann E, Coman MC, Beck KF, Cinatl J, Hailer NP, Auth MK, Bechstein WO, Shipkova M, and Blaheta RA. The immunosuppressive drug mycophenolate mofetil impairs the adhesion capacity of gastrointestinal tumour cells. Clin Exp Immunol 134(2):238-45, 2003

35. Xu D, Falke D, and Juliano RL. P53-dependent cell-killing by selective repression of thymidine kinase and reduced prodrug activation. Mol Pharmacol 64(2):289-97, 2003

36. Falke D and Juliano RL. Selective gene regulation with designed transcription factors: implications for therapy. Curr Opin Mol Ther 5(2):161-6, 2003

37. Falke D, Fisher M, Ye D, and Juliano RL. Design of artificial transcription factors to selectively regulate the pro-apoptotic bax gene. Nucleic Acids Res 31(3):e10, 2003

38. Wolter F, Turchanowa L, and Stein J. Resveratrol-induced modification of polyamine metabolism is accompanied by induction of c-Fos. Carcinogenesis 24(3):469-74, 2003

39. Milovic V and Turchanowa L. Polyamines and colon cancer. Biochem Soc Trans 31(2):381-3, 2003

40. Mühl H and Pfeilschifter J. A short summary. The history of glucocorticoids. Pharm Unserer Zeit 32(4):284-7, 2003

41. Pfeilschifter J and Huwiler A. Inflammation. Encyclopedic Reference of Molecular Pharmacology, 2003

42. Eberhardt W and Kilz T. On genomic and nongenomic effects. Molecular basis of glucocorticoid action. Pharm Unserer Zeit 32(4):288-94, 2003

43. Frank S and Kämpfer H. Excisional wound healing. An experimental approach. Methods Mol Med 78:3-15, 2003

44. Gilchrist M, Hesslinger C, and Befus AD. Tetrahydrobiopterin, a Critical Factor in the Production and Role of Nitric Oxide in Mast Cells. J Biol Chem 278:50607-14, 2003

45. Raschke K, Shabahang M, and Wolf R. The slow and the quick anion conductance in whole guard cells: their voltage-dependent alternation, and the modulation of their activities by abscisic acid and CO2. Planta 217:639-50 (2003)

46. Keller T, Pleskova M, McDonald MC, Thiemermann C, Pfeilschifter J, and Beck KF. 
Identification of manganese superoxide dismutase as a NO-regulated gene in rat glomerular mesangial cells by 2D gel electrophoresis. Nitric Oxide 9:183-193, 2003

47. Aschrafi A, Shabahang S, Pfeilschifter J, and Huwiler A. Regulatory functions of protein 
kinase C isoenzymes in the kidney. Current Topics in Biochemical Research, Vol. 5, 2003

48. Shabahang S, Aschrafi A, Pfeilschifter J, and Huwiler A. Sphingolipids in Health and Disease. Recent Research Developments in Human Pathology, Vol. 1, 2003

49. Cornelissen G, Bertelsen HP, Lenz K, Hahn B, Schultz M, Scheffler U, Werner E, Leptien H, Krüß S, Jansen AK, Elsholz O, Gliem T, Wilhelm BU, Sowa E, Radeke HH, and Luttmann R. Production of recombinant proteins with Pichia pastoris in integrated processing. Engineering in Life Sciences, 3(9):361-370, 2003

50. Cornelissen G, Bertelsen HP, Hahn B, Schultz M, Scheffler U, Werner E, Leptien H, Krüß S, Jansen AK, Gliem T, Hielscher M, Wilhelm BU, Sowa E, Radeke HH, and Luttmann R. Herstellung rekombinanter Proteine mit Pichia pastoris in integrierter Prozessführung. Chemie Ingenieur Technik, 75(3):281-290, 2003

51. Lykke-Andersen K, Schaefer L, Menon S, Deng XW, Miller JB, Wei N. Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Mol Cell Biol, 23(19): 6790-6797, 2003

52. Tralhão JG, Schaefer L, Micegova M, Evaristo C, Schönherr E, Kayal S, Veiga-Fernandes H, Danel C, Aresta S, Iozzo RV, Kresse H, Lemarchand P. In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer. FASEB J, 17(3): 464-466, 2003

1. Pfeilschifter J, Beck KF, Eberhardt W, and Huwiler A. Changing gears in the course of glomerulonephritis by shifting superoxide to nitric oxide-dominated chemistry: a working hypothesis. Kidney Int. 61, 809-815, 2002

2. Pautz A, Franzen R, Dorsch S, Böddingshaus B, Briner VA, Pfeilschifter J, and Huwiler A. Cell-specific cross-communication between nitric oxide and superoxide determines ceramide formation and apoptosis in renal glomerular cells. Kidney Int. 61, 790-796, 2002

3. Frank S, Kämpfer H, Wetzler C, and Pfeilschifter J. Nitric oxide drives skin repair: novel functions of an established mediator. Kidney Int. 61, 882-888, 2002

4. Manderscheid M, Pereda-Fernandez C, and Pfeilschifter J. Cyclic AMP increases rat inhibitor of Apoptosis Protein (RIAP1) mRNA in Renal Mesangial Cells. Kidney Int. 61, 797-803, 2002

5. Stefan Frank and Heiko Kämpfer. Excisional Wound Healing: An Experimental Approach in "Wound healing: Methods and Protocols." Humana Press In., Totowa, USA, 3-15, 2002

6. Loew D and Kaszkin M. Biovailabilityof harpagoside and its relation to in-vitro/in-vivo conformity of cysteinyl-leukotriene biosynthesis. Clin. Pharmacol. Ther - Vol. 71, Nr 1, Jan 2002

7. Pfeilschifter J. Nitric oxide triggers the expression of proinflammatory and protective gene 
products in mesangial cells and the inflamed glomerulus. Nephrol. Dial. Transplant 17, 347-348, 2002

8. Eberhardt W, Beck KF, and Pfeilschifter J. Cytokine-induced expression of tPA is differentially modulated by NO and ROS in rat mesangial cells. Kidney Int. 61, 20-30, 2002

9. Dieter P, Kolada A, Kamionka S, Schadow A, and Kaszkin M. LPS-induced release of arachidonic acid and prostaglandins in liver macrophages: Involvement of group IV cytosolic phospholipase A2, but not by group V and group IIA secretory phosholipase A2. Cell Signal. 14, 199-204, 2002

10. Stallmeyer B, Anhold M, Wetzler C, Kahlina K, Pfeilschifter J, and Frank S. Regulation of eNOS in normal and diabetes-impaired skin repair: implications for tissue regeneration. Nitric Oxide: Biology and Chemistry 6, 168-177, 2002

11. Scholz-Pedretti K, Gans A, Beck KF, Pfeilschifter J, and Kaszkin M. Potentiation of TNFa-stimulated group IIA phospolipase A2 expression by PPARa activators in rat mesangial cells. J. Am. Soc. Nephrol. 13, 611-620, 2002

12. Beck GCH, Yard BA, Schulte J, Oberacker R, van Ackern K, van der Woude FJ, Krimsky M, Kaszkin M, and Yedgar S. Inhibition of LPS-induced chemokine production in human lung endothelial cells by lipid conjugates anchored to the membrane. Brit J of Pharm 135, 1665-1674, 2002

13. Urbich C, Reissner A, Chavakis E, Dernbach E, Haendeler J, Fleming I, Zeiher A, Kaszkin M, and Dimmeler S.Dephosphorylation of endothelial nitric oxide synthase contributes to the anti-angiogenic effects of endostatin. FASEB J. 16(7), 706-708, 2002

14. Schwarz M, Wahl M, Resch K, and Radeke HH. IFNg induces functional chemokine receptor expression in human mesangial cells. Clin Exp Immunol 2002, 128:285-294, 2002

15. Pfeilschifter J and Huwiler A. Inflammation. In Encyclopedic Reference of Molecular Pharmacology, Offermanns S, Rosenthal W (eds), Springer, Heidelberg 2002

16. Cattell V and Pfeilschifter J. Nitric oxide and renal inflammation. Kidney Int. 61, 781-782, 2002

17. Rodriguez I, Kaszkin M, Holloschi A, Kabsch K, Marques MM, Mao X, and Alonso A. Hyperosmotic stress induces phosphorylation of cytosolic phospholipase A2 in HaCaT cells by an epidermal growth factor receptor-mediated process. Cell Signal. 14, 839-848, 2002

18. Loew D und Kaszkin M. Äquivalenz von Extrakten: Möglichkeiten und Forschungsbedarf. In: Phytopharmaka VII – Forschung und klinische Anwendung. Schulz, Rietbrock, Roots, Loew eds.,Steinkopff Verlag, Darmstadt, Vol. 7, Kapitel 20, 2002

19. Rölz W, Xin C, Ren S, Pfeilschifter J, and Huwiler A. Interleukin-1 inhibits angiotensin II stimulated protein kinase B pathway in renal mesangial cells via the inducible nitric oxide synthase. Eur. J. Pharmacol. 10, 195-203, 2002

20. Eberhardt W, Schulze M, Engels C, Klasmeier E, and Pfeilschifter J. Glucocorticoid-mediated suppression of cytokine-induced matrix metalloproteinase-9 expression in rat mesangial cells: involvement of NF-kB and Ets transcription factors. Mol. Endocrinol. 16, 1752-1766, 2002

21. Huwiler A, Rölz W, Dorsch S, Ren S, and Pfeilschifter J. Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y2 purinoceptor in renal mesangial cells. Br. J. Pharmacol 136, 520-529, 2002

22. Schacke W, Beck KF, Pfeilschifter J, Koch F, and Hattenbach LO. Modulation of tissue 
plasminogen activator and plasminoge activator inhibitor-1 by transforming growth factor-b in human retinal glial cells. Invest Ophthalmol Vis Sci, 43, 2799-2805, 2002

23. Hellmuth M, Wetzler C, Nold M, Chang J-H, Frank S, Pfeilschifter J, and Mühl H. Expression of Interleukin-8, Heme Oxygenase-1, and Vascular Endothelial Growth Factor in DLD-1 Colon Carcinoma Cells Exposed to Pyrrolidine Dithiocarbamate. Carcinogenesis 8, 1273-1279, 2002

24. Eberhardt W, Engels C, Müller R, and Pfeilschifter J. Mechanism of dexamethasone-mediated inhibition of cAMP-induced tPA expression in rat mesangial cells. Kidney Int. 162, 809-821, 2002

25. Janssen U, Sowa E, Marchand P, Floege J, Phillips AO, and Radeke HH. Differential Expression of MCP-1 and its receptor CCR2 in glucose primed human mesangial cells. Nephron 92(4), 797-806, 2002

26. Radeke HH, Janssen-Graalfs I, Sowa EN, Löscher F, Schmidt RE, and Gessner J. Opposite regulation of type II and II receptors for immunoglobulin G in mouse glomerula mesangial cells. J Biol Chem 277(30), 27535-27544, 2002

27. Radeke HH, Tschernig T, Karulin A, Schumm G, Emancipator SN, Resch K, and Tary-Lehmann M. CD4+ T cells recognizing specific antigen deposited in glomeruli cause glomerulonephritis-like kidney injury. Clinical Immunology 104(2), 161-173, 2002

28. Eberhardt W, Akool EL-S, Rebhan J, Frank S, Beck KF, Franzen R, Hamada F MA, and Pfeilschifter J. Inhibition of cytokine-induced MMP-9 expression by PPARa agonists is indirect and is due to NO-mediated reduction of mRNA stability. J Biol Chem. 36, 33518-33528, 2002

29. Turchanowa L, Shvetsov AS, Demin AV, Khomutov AR, Wallace HM, Stein J, and Milovic V. Insufficiently charged isoteric analogue of spermine: interaction with polyamine uptake, and effect on Caco-2 cell growth. Biochem Pharmacol 64, 649-655, 2002

30. Li H, Junk P, Huwiler A, Burkhardt C, Strauch S, Wallerath T, Pfeilschifter J, and Förstermann U. Dual Effect of Ceramide on Human Endothelial Cells. Circulation 106, 2250-2256, 2002

31. Loew D and Kaszkin M. Approaching the problem of bioequivalence of Herbal Medicinal Products. Phytother.Res. 16, 705-711, 2002

32. Franzen R, Fabbro D, Aschrafi A, Pfeilschifter J, and Huwiler A. Nitric oxide induces degradation of the neutral ceramidase in rat renal mesangial cells and is counterregulated by protein kinase C. J. Biol. Chem 277, 46184-46190, 2002

33. Shabahang S, Huwiler A, and Pfeilschifter J. Identification of the LIM kinase-1 as a cermaide-regulated gene in renal mesangial cells. Biochem. Biophys. Res. Commun. 298, 408-413, 2002

34. Schnorr O, Bruch-Gerharz D, Suschek C, Beck KF, Pfeilschifter J, Ruzicka T, and Kolb-Bachofen V. Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation. American Journal of Pathology 2002

35. Uhlenbrock K, Gassenhuber H, and Kostenis E. Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. Cell Signal 14, 941-953, 2002

36. Franzen R, Pfeilschifter J, and Huwiler A. Nitric oxide induces neutral ceramidase degradation by the ubiquitin/proteasome complex in renal mesangial cell cultures. FEBS Letters 532, 441-444, 2002

37. Feng WH, Westphal E, Mauser A, Raab-Traub N, Gulley ML, Busson P, and Kenney SC. Use of adenovirus vectors expressing Epstein-Barr virus (EBV) immediate-early protein BZLF1 or BRLF1 to treat EBV-positive tumors. J Virol. 76, 10951-10959, 2002

38. Westphal EM and Melchner Hv H. Gene therapy approaches for the selective killing of cancer cells. Curr Pharm Des. 8, 1683-1694, 2002 Review

39. Loew D and Kaszkin M. Experimentell- und klinisch-pharmakologische Modelle zum Nachweis der analgetischen und antiphlogistischen Wirkungen von Teufelskralle. Ärztezeitschrift für Naturheilverfahren 43 (9), 576-585, 2002

40. Bauer M, Suppmann S, Meyer M, Hesslinger C, Gasser T, Widmer HR, and Ueffing M. Glial cell line-derived neurotrophic factor up-regulates GTP-cyclohydrolase I activity and tetrahydrobiopterin levels in primary dopaminergic neurones. J. Neurochem. 82, 1300-1310, 2002

41. Münchow S, Ferring D, Kahlina K, and Jansen RP. Characterization of Candida albicans ASH1 in Saccharomyces cerevisiae. Curr Genet 41, 73-81, 2002

1. Schadow A, Scholz K, Lambeau G, Gelb MH, Fürstenberger G, Pfeilschifter J, and Kaszkin M: Characterization of group X phospholipase A2 as the major enzyme secreted by human keratinocytes and its regulation by the phorbol ester TPA. J. Invest. Dermatol. 116, 31-39, 2001

2. Scholz-Pedretti K, Pfeilschifter J, and Kaszkin M: Potentiation of cytokine induction of group IIA phospholipase A2 in rat mesangial cells by ATP and adenosine via the A2A adenosine receptor. Brit. J. Pharmacol. 132, 37-46, 2001

3. Walpen S, Beck KF, Schaefer L, Raslik I, Eberhardt W, Schaefer RM, and Pfeilschifter J: Nitric oxide induces MIP-2 transcription in rat renal mesangial cells and in a rat model of glomerulonephritis. FASEB J. 15, 571-573, 2001

4. Milovic V, Turchanowa L, Khomutov AR, Khomutov RM, Caspary WF, and Stein J: Hydroxylamine-containing inhibitors of polyamine biosynthesis and impairment of colon cancer cell groth. Biochem. Pharmacol. 61, 199-206, 2001

5. Klasen S, Hammermann R, Fuhrmann M, Lindemann D, Beck KF, and Pfeilschifter J & Racké K: Glucocorticoids inhibit lipopolysaccharide-induced up-regulation of arginase in rat alveolar macrophages. Brit. J. Pharmacol. 132, 1349-1357, 2001

6. Manderscheid M, Messmer UK, Franzen R, and Pfeilschifter J: Regulation of IAP expression by nitric oxide and cytokines: relation to apoptosis induction in rat mesangial cells and RAW 264.7 macrophages. J. Am. Soc. Nephrol. 12, 1151-1163, 2001

7. Stallmeyer B, Pfeilschifter J, and Frank S: Systemically and topically supplemented leptin fails to reconstitute a normal angiogenic response during skin repair in diabetic ob/ob mice. Diabetologia 44, 471-479, 2001

8. Kämpfer H, Pfeilschifter J, and Frank S: Expressional regulation of angiopoietin-1 and -2 and the Tie-1 and -2 receptor tyrosine kinases during cutaneous wound healing: a comparative study of normal and impaired repair. Lab. Invest. 81, 361-373, 2001

9. Stallmeyer B, Kämpfer H, Podda M, Kaufmann R, Pfeilschifter J, and Frank S: A novel keratinocyte mitogen: regulation of leptin and its functional receptor in skin repair. J. Invest. Dermatol. 117, 98-105, 2001

10. Kämpfer H, Kolb N, Manderscheid M, Wetzler C, Pfeilschifter J, and Frank S: Macrophage-derived heme-oxygenase 1: expression, regulation, and possible functions in skin repair. Mol. Med. 7, 488-498, 2001

11. Pfeilschifter J, Eberhardt W, and Beck KF: Regulation of gene expression by nitric oxide. Pflügers Arch. Eur. J. Physiol. 442, 479-486, 2001

12. Loew D, Möllerfeld J, Schrödter A, Puttkammer S, and Kaszkin M: Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo. Clin. Pharmacol. Ther. 69, 356-364, 2001

13. Messmer UK, Pereda-Fernandez C, Manderscheid M, and Pfeilschifter J: Dexamethasone inhibits TNF-a-induced apoptosis and IAP protein downregulation in MCF-7 cells. Brit. J. Pharmacol. 133, 467-476, 2001

14. Huwiler A, Böddinghaus B, Pautz A, Dorsch S, Franzen R, Briner VA, Brade V, and Pfeilschifter J: Superoxide potently induces ceramide formation in glomerular endothelial cells.Biochem. Biophys. Res. Commun. 284, 404-410, 2001

15. Pfeilschifter J, Eberhardt W, and Huwiler A: Nitric oxide and mechanisms of redox signalling: Matrix and matrix-metabolizing enzymes as prime NO targets. Eur. J. Pharmacol. 429, 279-286, 2001

16. Schwarz M, and Murphy PM: Kaposi’s sarcoma-associated herpesvirus G protein-coupled receptor constitutively activates NF-kB andinduces proinflammatory cytokine and chemokine production via a C-terminal signaling determinant. J Immunol 167, 505-513, 2001

17. Franzen R, Pautz A, Brautigam L, Geisslinger G, Pfeilschifter J, and Huwiler A: Interleukin 1b induces chronic activation and de-novo synthesis of neutral ceramidase in renal mesangial cells. J Biol Chem 276, 35382-35389, 2001

18. Eberhardt W: Differentielle Modulierung der IL-1b vermittelten Expression der Matrixmetalloprotease-9 (MMP-9) durch ROS und NO. Immunologie Aktuell 1, 132-133, 2001

19. Tegeder I, Pfeilschifter J, and Geisslinger G: Cyclooxygenase-independent actions of cyclooxygenase inhibitors. FASEB J. 15, 2057-2072, 2001

20. Beck KF, Walpen S, Eberhardt W, and Pfeilschifter J: Downregulation of integrin-linked kinase mRNA expression by nitric oxide in rat glomerular mesangial cells. Life Sci 69, 2945-2955, 2001

21. Schwarz M, and Radeke HH: Chemokines and Inflammatory Renal Diseases. Kidney Blood Press Res, 24, 409-411, 2001

22. Paulukat J, Bosmann M, Nold M, Garkisch S, Kämpfer H, Frank S, Raedle J, Zeuzem S, Pfeilschifter J, and Mühl H:Expression and release of IL-18 binding protein in response to Interferon-g. J Immunol, 167 (12), 7038-7043, 2001

23. Turchanowa L, Dauletbaev N, Milovic V, and Stein J: Nonsteroidal anti-inflammatory drugs stimulate spermidine/spermine acetyltransferase and deplete polyamine content in colon cancer cells.Europ. J Clin Invest, 31, 887-893, 2001

24. Walker G, Pfeilschifter J, Otten U and Kunz D: Proteolytic cleavage of inducible nitric oxide synthase (iNOS) by calpain I. Biochim Biophys Acta 19, 1568: 216-214, 2001

25. Pfeilschifter J and Beck KF Beck: Räumliche und zeitliche Aspekte der Genregulation durch Stickoxid (NO) . NephroNews 2001, 2: 13-15

26. Andreu T, Ebensperger C, Westphal EM, Klenner T, Stewart AF, Westhof A, Müller P, Knaus R, and von Melchner H:Self-deleting suicide vectors (SDSV): selective killing of p53-deficient cancer cells. Cancer Res, 61, 6925-6930, 2001

1. Eberhardt W, Beeg T, Beck KF, Walpen S, Gauer S, Böhles H, and Pfeilschifter J: Nitric oxide modulates expression of matrix metalloproteinase-9 in rat mesangial cells. Kidney Int. 57, 59-69, 2000

2. Walpen S, Beck KF, Eberhardt W, Apel M, Chatterjee PK, Wray G, Thiemermann C, and Pfeilschifter J: Downregulation of SPARC expression is mediated by nitric oxide in rat mesangial cells and during endotoxemia in the rat. J. Am. Soc. Nephrol. 11, 468-476, 2000

3. Huwiler A, Wartmann M, van den Bosch H, and Pfeilschifter J: Extracellular nucleotides activate the p38-stress-activated protein kinase cascade in glomerular mesangial cells. Br. J. Pharmacol. 129, 612-618, 2000

4. Frank S, Kämpfer H, Podda M, Kaufmann R, and Pfeilschifter J: Identification of Copper/Zinc Superoxide Dismutase as a Nitric Oxide-regulated Gene in human Keratinocytes (HaCaT): Implications for Keratinocyte Proliferation. Biochem. J. 346, 719-728, 2000

5. Pfeilschifter J, and Huwiler A: Ceramides as key players in cellular stress response. News Physiol. Sci. 15, 11-15, 2000

6. Muhl H, Kämpfer H, Bosmann M, Frank S, Radeke H, and Pfeilschifter J: Interferon-gamma mediates gene expression of IL-18 binding protein in non-leukocytic cells. Biochem. Biophys. Res. Commun. 267, 960-963, 2000

7. Frank S, Kämpfer H, Wetzler C, Stallmeyer B, and Pfeilschifter J: Large induction of the chemotactic cytokine RANTES during wound repair: a regulatory role for nitric oxide in keratinocyte-derived RANTES expression. Biochem J. 347, 265-273, 2000

8. Messmer UK, Winkel G, Briner VA, and Pfeilschifter J: Suppression of apoptosis by glucocorticoids in glomerular endothelial cells: Effects on cytochrome c-release, Bak upregulation, Bcl-xL downregulation and caspase-3-activation. Br. J. Pharmacol. 129, 1673-1683, 2000

9. Aicher A, Hayden-Ledbetter M, Brady WA, Pezzutto A, Richter G, Magaletti D, Buckwalter S, Ledbetter JA, and Clark EA: Characterization of human inducible costimulator ligand expression and function. J. Immunol. 164, 4689-4696, 2000

10. Zacharowski K, Frank S, Otto M, Chatterjee PK, Cuzzocrea S, Hafner G, Pfeilschifter J, and Thiemermann C:Lipoteichoic acid induces delayed protection in the rat heart: a comparison with endotoxin. Arteriosc. Thromb. Vasc. Biol. 20, 1521-1528, 2000

11. Pfeilschifter J: Adhesion Molecules. Schweiz. Rundsch. Med. Prax. 89, 439-442, 2000

12. Scholz K, Eberhardt W, Rupprecht G, Beck KF, Spitzer S, Pfeilschifter J, and Kaszkin M: Inhibition of NFkB-mediated proinflammatory gene expression in rat mesangial cells by the enolized 1,3-dioxane-4,6-dione-5-carboxamide CGP-43182. Brit. J. Pharmacol. 130, 1183-1190, 2000

13. Huwiler A, Kolter T, Pfeilschifter J, and Sandhoff K: Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochem. Biophys. Acta 1485, 63-99, 2000

14. Wetzler C, Kämpfer H, Stallmeyer B, Pfeilschifter J, and Frank S: Large and sustained inductionof chemokines during impaired wound healing in the genetically diabetic mouse: Prolonged persistance of neutrophils and macrophages during the late phase of repair. J. Invest. Dermatol. 115, 245-253, 2000

15. Wetzler C, Kämpfer H, Pfeilschifter J, and Frank S: Keratinocyte-derived chemotactic cytokines: expressional modulation by nitric oxide in vitro and during cutaneous wound repair in vivo. Biochem. Biophys. Res. Commun. 274, 689-696, 2000

16. Frank S, Stallmeyer B, Kämpfer H, Kolb N, and Pfeilschifter J: Leptin enhances wound reepithelialization: Implication for a direct function of leptin in skin repair. J. Clin. Invest. 106, 501-509, 2000

17. Maihofner C, Euchenhofer C, Tegeder I, Beck KF, Pfeilschifter J, and Geisslinger G: Regulation and immunhistochemical localization of nitric oxide synthases and soluble guanylyl cyclase in mouse spinal cord following nociceptive stimulation.Neurosci. Lett. 290, 71-75, 2000

18. Ziegler I, McDonaldo T, Hesslinger C, Pelletier I, and Boyle P: Development of the pteridine pathway in the zebrafish, Danio rerio. J. Biol. Chem. 275, 18926-18932, 2000

19. Muhl H, Chang JY, Huwiler A, Bosmann M, Paulukat J, Ninic R, Nold M, Hellmuth M, and Pfeilschifter J: Nitric oxide augments release of chemokines from monocytic U937 cells: Modulation by antiinflammatory pathways. Free Radical Bio. Med. 29, 969-980, 2000

20. Messmer UK, Briner VA, and Pfeilschifter J: Basic fibroblast growth factor selectively enhances tumor necrosis factor-alpha-induced apoptotic cell death in glomerular endothelial cells: Effects on apoptotic signaling pathways. J. Am. Soc. Nephrol. 11, 2199-2211, 2000

21. Messmer UK, and Pfeilschifter J: New insights into the mechanism for clearance of apoptotic cells. Bio Essays 22, 878-881, 2000

22. Eberhardt W, Huwiler A, Beck KF, Walpen S, and Pfeilschifter J: Amplification of interleukin-1beta-induced MMP-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-kappaB and AP-1 and involves activation of the MAPK-pathways. J. Immunol. 165, 5788-5797, 2000

23. Huwiler A, Johansen B, Skarstad A, and Pfeilschifter J: Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and faciliates its membrane docking and arachidonic acid release. FASEB J. 10.1096/fj.00-0370fje, 2000

24. Pfeilschifter J: Signalling pathways of nitric oxide (NO). Kidney Blood Press. Res. 23, 159-161, 2000

25. Kämpfer H, Muhl H, Manderscheid M, Kalina U, Kauschat D, Pfeilschifter J, and Frank S: Regulation of IL-18 expression in keratinocytes (HaCaT): Implications for early wound healing. Eur. Cytokine Network 11, 626-633, 2000

26. Kämpfer H, Paulukat J, Muhl H, Wetzler C, Pfeilschifter J, and Frank S: Lack of interferon- gamma production despite the presence of interleukin-18 during cutaneous wound healing. Molecular Medicine 6, 1016-1027, 2000

27. Turchanowa L, Rogozkin VA, Milovic V, Feldkoren BI, Caspary WF, and Stein J: Influence of physical exercise on polyamine synthesis in the rat skeletal muscle. Eur. J. of Clin. Invest. 30, 72-78, 2000

28. Mankel A, Krause K, Genenger M, Kost G and Kothe E: A hydrophobin accumulated in the Hartig' net of ectomycorrhiza formed between Tricholoma terreum and its compatible host tree is missing in an incompatible association. J. of Applied Botany 74, 95-99, 2000

29. Martin U, Winkler ME, Id M, Radeke H, Arseniev L, Takeuchi Y, Simon AR, Patience C, Haverich A and Steinhoff G:Productive infection of primary human endothelial cells by pig endogenous retrovirus (PERV). Xenotransplantation 7, 138-142, 2000

30. Marchand P, Resch K and Radeke HH: Selective inhibition of monocyte chemoattractant protein-1 gene expression in human embryonal kidney cells by specific triple helix-forming oligonucleotides. J. Immunol. 164, 2070-2076, 2000

1. Frank S, Stallmeyer B, Kämpfer H, Schaffner C, and Pfeilschifter J: Differential regulation of vascular endothelial growth factor and its receptor fms-like-tyrosine kinase is mediated by nitric oxide in rat renal mesangial cells. Biochem. J. 338, 367-374, 1999

2. Huwiler A, Pfeilschifter J, and van den Bosch H: Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells. J. Biol. Chem. 274, 7190-7195, 1999

3. Huwiler A, and Pfeilschifter J: Nitric oxide stimulates the stress-activated protein kinase p38 in rat renal mesangial cells. J. Exp. Biol. 202, 655-660, 1999

4. Beck KF, Eberhardt W, Frank S, Huwiler A, Messmer UK, Muhl H, and Pfeilschifter J: Inducible NO synthase: role in cellular signaling. J. Exp. Biol. 202, 645-653, 1999

5. Stallmeyer B, Schwarz G, Schulze J, Nerlich A, Reiss J, Kirsch J, and Mendel RR: The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells. Proc. Natl. Acad. Sci. USA 96,1333-1338, 1999

6. Frank S, Zacharowski K, Wray GM, Thiemermann C, and Pfeilschifter J: Identification of copper/zinc superoxide dismutase as a novel nitric oxide-regulated gene in rat glomerular mesangial cells and kidneys of endotoxemic rats. FASEB J. 13, 869-82, 1999

7. Rupprecht G, Scholz K, Beck KF, Geiger H, Pfeilschifter J, and Kaszkin M: Cross-talk between group IIA-phospholipase A2 and inducible NO-synthase in rat renal mesangial cells. Brit. J. Pharmacol. 127, 51-56, 1999

8. Messmer UK, Briner V, and Pfeilschifter J: Tumor necrosis factor alpha and lipopolysaccharide potently induce apoptotic cell death in bovine glomerular endothelial cells. Kidney Int. 55, 2322-2337, 1999

9. Huwiler A, Dorsch S, Briner V, van den Bosch H, and Pfeilschifter J: Nitric oxide stimulates chronic ceramide formation in glomerular endothelial cells. Biochem. Biophys. Res. Commun. 258, 60-65, 1999

10. Messmer UK, Winkel G, Briner V, and Pfeilschifter J: Glucocorticoids potently block tumor necrosis factor alpha and lipopolysaccharide-induced apoptotic cell death in bovine glomerular endothelial cells upstream of caspase 3 activation. Brit. J. Pharmacol. 127, 1633-1640, 1999

11. Pfeilschifter J, and Muhl H: Immunopharmacology: Antiinflammatory therapy targeting transcription factors. Eur. J. Pharmacol. 375, 237-245, 1999

12. Kämpfer H, Kalina U, Muhl H, Pfeilschifter J, and Frank S: Counterregulation of Interleukin-18 mRNA and protein expression during cutaneous wound repair in mice. J. Invest. Dermatol. 113, 369-374, 1999

13. Muhl H, Nold M, Chang J, Frank S, Eberhardt W, and Pfeilschifter J: Expression and release of chemokines associated with apoptotic cell death in human promonocytic U937 cells and peripheral blood mononuclear cells. Eur. J. Immunol. 29, 3225-3235, 1999

14. Scholz K, Vlachojannis G, Schini-Kerth V, Van den Bosch H, Kaszkin M, and Pfeilschifter J: Protein kinase C modulates cytokine-induced expression of group IIA phospholipase A2 in rat renal mesangial cells. Biochem. Pharmacol. 58, 1751-1758,1999

15. Crusius K, Kaszkin M, Kinzel V, and Alonso A: The human papillomavirus type 16 E5 protein modulates phospholipase c-gamma-1 activity and phosphatidylinositol turnover in mouse fibroblasts. Oncogene 18, 6714-6718, 1999

16. Stallmeyer B, Drugeon G, Reiss J, Haenni AL, and Mendel RR: Human molybdopterin synthase gene: identification of a bicistronic transcript with overlapping reading frames. Am. J. Hum. Genet. 64, 698-705, 1999

17. Reiss J, Dorche C, Stallmeyer B, Mendel RR, Cohen N, and Zabot MT: Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B. Am. J. Hum. Genet. 64, 706-711, 1999

18. Frank S, Stallmeyer B, Kämpfer H, Kolb N, and Pfeilschifter J: Nitric oxide triggers enhanced induction of Vascular Endothelial Growth Factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair. FASEB J. 13, 2002-2014, 1999

19. Stallmeyer B, Kämpfer H, Kolb N, Pfeilschifter J, and Frank S: The function of nitric oxide in wound repair: Inhibition of inducible Nitric-Oxide-Synthase severely impairs wound reepithelialization. J. Invest. Dermatol. 113, 1090-1098, 1999

20. Aicher A, Shu GL, Magaletti D, Mulvania T, Pezzutto A, Craxton A, and Clark EA: Differential Role for p38 Mitogen-Activated Protein Kinase in Regulating CD40-Induced Gene Expression in Dendritic Cells and B Cells. J. Immunol. 163, 5786-5795, 1999