Else Kröner-Fresenius-Zentrum (EKFZ)

Independent and Dose-Dependent Contributions of Clonal Hematopoiesis and Mosaic Loss of Y to Incident Heart Failure.
Weyrich M, Ware A, Windschmitt J, Sarakpi T, Abplanalp WT, Dimmeler S, Speer T*, Zeiher AM*.
Eur J Heart Fail. 2026

CCL2 as a microvascular "tone breaker": inflammatory signaling and the failure of kidney autoregulation in salt-sensitive hypertension.
Weyrich M, Speer T.
Kidney Int. 2026

Disconnected universes: advanced kidney research versus absence of basic kidney care in high income countries.
Speer T.
Nephrol Dial Transplant. 2026

Urinary DKK3 as a biomarker for pediatric CKD progression: a review of current evidence.
Boeckhaus J, Licht C, Hall M, Oh J, Speer T.
Biomark Med. 2026

Tubular MAG3 Extraction Rate is a Predictor of Short-Term and Long-Term Outcome After Kidney Transplantation: A Prospective Observational Study.
Buckenmayer A, Werner R, Groener D, Klimek K, Grünwald F, van Drongelen N, Speer T, Weyrich M.
Clin Nucl Med. 2026

The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells.
Herrle N, Malacarne PF, Warwick T, Cabrera-Orefice A, Chen Y, Gheisari M, Chatterjee S, Leisegang MS, Sarakpi T, Wionski S, Lopez M, Kader C, Teichmann T, Drekolia MK, Koch I, Keßler M, Klein S, Erhard Uschner F, Trebicka J, Brunst S, Proschak E, Günther S, Rosas-Lemus M, Baumgarten N, Klatt S, Speer T, Bibli SI, Segarra M, Acker-Palmer A, Wagner JUG, Wittig I, Dimmeler S, Schulz MH, Richards JB, Gilsbach R, T Denton T, Fleming I, Hannibal L, Brandes RP, Rezende F.
EMBO J. 2026

Loss of Y chromosome: proteomic signatures in human cardiovascular disease.
Weyrich M, Windschmitt J, Abplanalp WT, Ware A, Sarakpi T, Zewinger S, Zanders L, Dimmeler S, Zeiher AM, Speer T.
Eur Heart J. 2025

Impaired Secondary Platelet Response in Chronic Kidney Disease as a Consequence of Prior Platelet Activation.
Baaten CCFMJ, Wollenhaupt J, Henning TM, Vondenhoff S, Schröer JR, Stamellou E, Saritas T, Kurt B, Boger L, Antwerpen A, Hermann J, Nagy M, Sternkopf M, Buhl EM, Raffetseder U, van der Meijden PEJ, Kuijpers MJE, Spronk HMH, Schunk SJ, Jankowski J, Fliser D, Speer T, Boor P, Kramann R, Kahles F, Floege J, Marx N, Noels H.
JACC Basic Transl Sci. 2025

Dickkopf 3 - A novel biomarker for chronic kidney disease and its progression in people living with HIV?
Callensee L, Esser S, Jaeger J, Zwanziger D, Kowalczyk M, Mavarani L, Speer T, Gäckler A, Dolff S, Witzke O, Schoenfeld A.
Int J STD AIDS. 2025

Prognostic significance of somatic mutations in myeloid cells of men with chronic heart failure - interaction between loss of Y chromosome and clonal haematopoiesis.
Cremer S, von Scheidt M, Kirschbaum K, Tombor L, Mas-Peiro S, Abplanalp W, Rasper T, Ware A, Schuff A, Berkowitsch A, Krefting J, Leistner D, Schunkert H, Speer T, Dimmeler S, Zeiher AM.
Eur J Heart Fail. 2025

Guanidinylation compromises the anti-inflammatory and anti-oxidative properties of apolipoprotein A-I in chronic kidney disease progression.
Bonnin-Marquez A, Jankowski J, Maas SL, Hermann J, Kahles F, Lellig M, Fliser D, Schunk S, Stamellou E, Berger M, Speer T, Kalim S, Leong Wong DW, van der Vorst EPC, Jankowski V.
Kidney Int. 2025

Mosaic loss of Y chromosome and mortality after coronary angiography.
Weyrich M, Zewinger S, Sarakpi T, Rasper T, Kleber ME, Cremer S, Zanders L, Fleck F, Siegbahn A, Wallentin L, Abplanalp WT, Nerbas L, Fay S, Eberle AL, Dimmeler S, März W, Zeiher AM*, Speer T*.
Eur Heart J. 2025

Purinergic receptor P2X7 regulates interleukin-1α mediated inflammation in chronic kidney disease in a reactive oxygen species-dependent manner.
Amini M, Frisch J, Jost P, Sarakpi T, Selejan SR, Becker E, Sellier A, Engel J, Böhm M, Hohl M, Noels H, Maack C, Schunk S, Roma LP, Niemeyer BA, Speer T, Alansary D.
Kidney Int. 2025

Urinary Dickkopf-3 Reflects Disease Severity and Predicts Short-Term Kidney Function Decline in Renal Ciliopathies.
Dahmer-Heath M, Gerß J, Fliser D, Liebau MC, Speer T, Telgmann AK, Burgmaier K, Pennekamp P, Pape L, Schaefer F, Konrad M, König JC; NEOCYST Consortium.
Kidney Int Rep. 2024

Molecular imaging along the heart-kidney axis.
Klimek K, Groener D, Chen X, Rowe SP, Speer T, Higuchi T, Werner RA.
Theranostics. 2024

Novel Long Noncoding RNA HEAT4 Affects Monocyte Subtypes, Reducing Inflammation and Promoting Vascular Healing.
Kneuer JM, Grajek IA, Winkler M, Erbe S, Meinecke T, Weiss R, Garfias-Veitl T, Sheikh BN, König AC, Möbius-Winkler MN, Kogel A, Kresoja KP, Rosch S, Kokot KE, Filipova V, Gaul S, Thiele H, Lurz P, von Haehling S, Speer T, Laufs U, Boeckel JN.
Circulation. 2024

Loss of Y Chromosome and Cardiovascular Events in Chronic Kidney Disease.
Weyrich M, Cremer S, Gerster M, Sarakpi T, Rasper T, Zewinger S, Patyna SR, Leistner DM, Heine GH, Wanner C, März W, Fliser D, Dimmeler S, Zeiher AM, Speer T.
Circulation. 2024

FAPI-PET in Cardiovascular Disease.
Higuchi T, Serfling SE, Leistner DM, Speer T, Werner RA.
Semin Nucl Med. 2024

Lineage tracing reveals transient phenotypic adaptation of tubular cells during acute kidney injury.
Buse M, Cheng M, Jankowski V, Lellig M, Sterzer V, Strieder T, Leuchtle K, Martin IV, Seikrit C, Brinkkoettter P, Crispatzu G, Floege J, Boor P, Speer T, Kramann R, Ostendorf T, Moeller MJ, Costa IG, Stamellou E.
iScience. 2024

Platelets from patients with chronic inflammation have a phenotype of chronic IL-1β release.
Berger M, Maqua H, Lysaja K, Mause SF, Hindle MS, Naseem K, Dahl E, Speer T, Marx N, Schütt K.
Res Pract Thromb Haemost. 2023

Mapping cardiac remodeling in chronic kidney disease.
Kaesler N, Cheng M, Nagai J, O'Sullivan J, Peisker F, Bindels EMJ, Babler A, Moellmann J, Droste P, Franciosa G, Dugourd A, Saez-Rodriguez J, Neuss S, Lehrke M, Boor P, Goettsch C, Olsen JV, Speer T, Lu TS, Lim K, Floege J, Denby L, Costa I, Kramann R.
Sci Adv. 2023

Leukocyte-endothelial interaction in CKD.
Sarakpi T, Mesic A, Speer T.
Clin Kidney J. 2023

Membrane-bound Interleukin-1α mediates leukocyte adhesion during atherogenesis.
Maeder C, Speer T, Wirth A, Boeckel JN, Fatima S, Shahzad K, Freichel M, Laufs U, Gaul S.
Front Immunol. 2023

Urinary DKK3 as a biomarker for short-term kidney function decline in children with chronic kidney disease: an observational cohort study.
Speer T, Schunk SJ, Sarakpi T, Schmit D, Wagner M, Arnold L, Zewinger S, Azukaitis K, Bayazit A, Obrycki L, Kaplan Bulut I, Duzova A, Doyon A, Ranchin B, Caliskan S, Harambat J, Yilmaz A, Alpay H, Lugani F, Balat A, Arbeiter K, Longo G, Melk A, Querfeld U, Wühl E, Mehls O, Fliser D, Schaefer F; 4C Study Investigators, ESCAPE Trial Investigators.
Lancet Child Adolesc Health. 2023

Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form.
Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, Klug M, Schunk SJ, Schmit D, Kramann R, Körbel C, Ampofo E, Laschke MW, Selejan SR, Paschen A, Herter T, Gaul S, Silbernagel G, Sester M, Sester U, Aßmann G, Bals R, Kostner G, Jahnen-Dechent W, Menger MD, Rohrer L, März W, Böhm M, Jankowski J, Kopf M, Latz E, Niemeyer BA, Fliser D, Laufs U, Speer T.
Nat Immunol. 2023

Adult human kidney organoids originate from CD24⁺ cells and represent an advanced model for adult polycystic kidney disease.
Xu Y, Kuppe C, Perales-Patón J, Hayat S, Kranz J, Abdallah AT, Nagai J, Li Z, Peisker F, Saritas T, Halder M, Menzel S, Hoeft K, Kenter A, Kim H, van Roeyen CRC, Lehrke M, Moellmann J, Speer T, Buhl EM, Hoogenboezem R, Boor P, Jansen J, Knopp C, Kurth I, Smeets B, Bindels E, Reinders MEJ, Baan C, Gribnau J, Hoorn EJ, Steffens J, Huber TB, Costa I, Floege J, Schneider RK, Saez-Rodriguez J, Freedman BS, Kramann R.
Nat Genet. 2022

Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease.
Wollenhaupt J, Frisch J, Harlacher E, Wong DWL, Jin H, Schulte C, Vondenhoff S, Moellmann J, Klinkhammer BM, Zhang L, Baleanu-Curaj A, Liehn EA, Speer T, Kazakov A, Werner C, van der Vorst EPC, Selejan SR, Hohl M, Böhm M, Kramann R, Biessen EAL, Lehrke M, Marx N, Jankowski J, Maack C, Boor P, Prates Roma L, Noels H.
Redox Biol. 2022

Targeting innate immunity-driven inflammation in CKD and cardiovascular disease.
Speer T, Dimmeler S, Schunk SJ, Fliser D, Ridker PM.
Nat Rev Nephrol. 2022

Klotho in diabetic kidney disease: more than dust in the Wnt.
Speer T, Schunk SJ.
Kidney Int. 2022

Renal denervation reduces atrial remodeling in hypertensive rats with metabolic syndrome.
Selejan SR, Linz D, Mauz M, Hohl M, Huynh AKD, Speer T, Wintrich J, Kazakov A, Werner C, Mahfoud F, Böhm M.
Basic Res Cardiol. 2022

Targeting Pancreatic Islet NLRP3 Improves Islet Graft Revascularization.
Wrublewsky S, Speer T, Nalbach L, Boewe AS, Pack M, Alansary D, Roma LP, Hoffmann MDA, Schmitt BM, Weinzierl A, Menger MD, Laschke MW, Ampofo E.
Diabetes. 2022

Response by Schunk and Speer to the Letter Regarding Article, "Interleukin-1α Is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease".
Schunk SJ, Speer T.
Circulation. 2022

Chemokine CCL9 Is Upregulated Early in Chronic Kidney Disease and Counteracts Kidney Inflammation and Fibrosis.
Hemmers C, Schulte C, Wollenhaupt J, Wong DWL, Harlacher E, Orth-Alampour S, Klinkhammer BM, Schirmer SH, Böhm M, Marx N, Speer T, Boor P, Jankowski J, Noels H.
Biomedicines. 2022

Renal Denervation Prevents Atrial Arrhythmogenic Substrate Development in CKD.
Hohl M, Selejan SR, Wintrich J, Lehnert U, Speer T, Schneider C, Mauz M, Markwirth P, Wong DWL, Boor P, Kazakov A, Mollenhauer M, Linz B, Klinkhammer BM, Hübner U, Ukena C, Moellmann J, Lehrke M, Wagenpfeil S, Werner C, Linz D, Mahfoud F, Böhm M.
Circ Res. 2022

Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk.
Böhm M, Schumacher H, Werner C, Teo KK, Lonn EM, Mahfoud F, Speer T, Mancia G, Redon J, Schmieder RE, Sliwa K, Marx N, Weber MA, Laufs U, Williams B, Yusuf S, Mann JFE.
Cardiovasc Diabetol. 2022

CETP inhibitors revisited.
Laufs U, Speer T.
Eur Heart J. 2022

IgE is associated with exacerbations and lung function decline in COPD.
Lommatzsch M, Speer T, Herr C, Jörres RA, Watz H, Müller A, Welte T, Vogelmeier CF, Bals R; COSYCONET study group.
Respir Res. 2022

A systematic review and meta-analysis of murine models of uremic cardiomyopathy.
Soppert J, Frisch J, Wirth J, Hemmers C, Boor P, Kramann R, Vondenhoff S, Moellmann J, Lehrke M, Hohl M, van der Vorst EPC, Werner C, Speer T, Maack C, Marx N, Jankowski J, Roma LP, Noels H.
Kidney Int. 2022

Altered vitamin K biodistribution and metabolism in experimental and human chronic kidney disease.
Kaesler N, Schreibing F, Speer T, Puente-Secades S, Rapp N, Drechsler C, Kabgani N, Kuppe C, Boor P, Jankowski V, Schurgers L, Kramann R, Floege J.
Kidney Int. 2022

Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease.
Jankowski V, Saritas T, Kjolby M, Hermann J, Speer T, Himmelsbach A, Mahr K, Heuschkel MA, Schunk SJ, Thirup S, Winther S, Bottcher M, Nyegard M, Nykjaer A, Kramann R, Kaesler N, Jankowski J, Floege J, Marx N, Goettsch C.
Kidney Int. 2022

Guanidinylated Apolipoprotein C3 (ApoC3) Associates with Kidney and Vascular Injury.
Schunk SJ, Hermann J, Sarakpi T, Triem S, Lellig M, Hahm E, Zewinger S, Schmit D, Becker E, Möllmann J, Lehrke M, Kramann R, Boor P, Lipp P, Laufs U, März W, Reiser J, Jankowski J, Fliser D, Speer T, Jankowski V.
J Am Soc Nephrol. 2021

Distinct Patterns of Blood Cytokines Beyond a Cytokine Storm Predict Mortality in COVID-19.
Herr C, Mang S, Mozafari B, Guenther K, Speer T, Seibert M, Srikakulam SK, Beisswenger C, Ritzmann F, Keller A, Mueller R, Smola S, Eisinger D, Zemlin M, Danziger G, Volk T, Hoersch S, Krawczyk M, Lammert F, Adams T, Wagenpfeil G, Kindermann M, Marcu C, Ataya ZWD, Mittag M, Schwarzkopf K, Custodis F, Grandt D, Schaefer H, Eltges K, Lepper PM, Bals R; CORSAAR Study Group.J 
Inflamm Res. 2021

Renal markers for monitoring acute kidney injury transition to chronic kidney disease after COVID-19.
Husain-Syed F, Villa G, Wilhelm J, Samoni S, Matt U, Vadász I, Tello K, Jennert B, Dietrich H, Trauth J, Kassoumeh S, Arneth B, Renz H, Sander M, Herold S, Seeger W, Schunk SJ, Speer T, Birk HW, Ronco C.
Nephrol Dial Transplant. 2021

Measurement of urinary Dickkopf-3 uncovered silent progressive kidney injury in patients with chronic obstructive pulmonary disease.
Schunk SJ, Beisswenger C, Ritzmann F, Herr C, Wagner M, Triem S, Hütter G, Schmit D, Zewinger S, Sarakpi T, Honecker A, Mahadevan P, Boor P, Wagenpfeil S, Jörres R, Watz H, Welte T, Vogelmeier CF, Gröne HJ, Fliser D, Bals R, Speer T.
Kidney Int. 2021

Interleukin-1α Is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease.
Schunk SJ, Triem S, Schmit D, Zewinger S, Sarakpi T, Becker E, Hütter G, Wrublewsky S, Küting F, Hohl M, Alansary D, Prates Roma L, Lipp P, Möllmann J, Lehrke M, Laschke MW, Menger MD, Kramann R, Boor P, Jahnen-Dechent W, März W, Böhm M, Laufs U, Niemeyer BA, Fliser D, Ampofo E, Speer T.
Circulation. 2021

Registration of Image Modalities for Analyses of Tissue Samples Using 3D Image Modelling.
Hermann J, Brehmer K, Jankowski V, Lellig M, Hohl M, Mahfoud F, Speer T, Schunk SJ, Tschernig T, Thiele H, Jankowski 
J.Proteomics Clin Appl. 2021

Orphan nuclear receptor ERR-γ regulates hepatic FGF23 production in acute kidney injury.
Radhakrishnan K, Kim YH, Jung YS, Kim DK, Na SY, Lim D, Kim DH, Kim J, Kim HS, Choy HE, Cho SJ, Lee IK, Ayvaz Ş, Nittka S, Fliser D, Schunk SJ, Speer T, Dooley S, Lee CH, Choi HS.
Proc Natl Acad Sci U S A. 2021

Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality.
Schunk SJ, Kleber ME, März W, Pang S, Zewinger S, Triem S, Ege P, Reichert MC, Krawczyk M, Weber SN, Jaumann I, Schmit D, Sarakpi T, Wagenpfeil S, Kramann R, Boerwinkle E, Ballantyne CM, Grove ML, Tragante V, Pilbrow AP, Richards AM, Cameron VA, Doughty RN, Dubé MP, Tardif JC, Feroz-Zada Y, Sun M, Liu C, Ko YA, Quyyumi AA, Hartiala JA, Tang WHW, Hazen SL, Allayee H, McDonough CW, Gong Y, Cooper-DeHoff RM, Johnson JA, Scholz M, Teren A, Burkhardt R, Martinsson A, Smith JG, Wallentin L, James SK, Eriksson N, White H, Held C, Waterworth D, Trompet S, Jukema JW, Ford I, Stott DJ, Sattar N, Cresci S, Spertus JA, Campbell H, Tierling S, Walter J, Ampofo E, Niemeyer BA, Lipp P, Schunkert H, Böhm M, Koenig W, Fliser D, Laufs U, Speer T; eQTLGen consortium; BIOS consortium.
Eur Heart J. 2021

J-shaped association between circulating apoC-III and cardiovascular mortality.
Silbernagel G, Scharnagl H, Kleber ME, Hoffmann MM, Delgado GE, Stojakovic T, Gary T, Zeng L, Ritsch A, Zewinger S, Speer T, Schunkert H, Landmesser U, März W, Grammer TB.
Eur J Prev Cardiol. 2022

Genetic Variation in Sodium-glucose Cotransporter 2 and Heart Failure.
Katzmann JL, Mason AM, März W, Kleber ME, Niessner A, Blüher M, Speer T, Laufs U.
Clin Pharmacol Ther. 2021

Lipoproteins in chronic kidney disease: from bench to bedside.
Speer T, Ridker PM, von Eckardstein A, Schunk SJ, Fliser D.
Eur Heart J. 2021

Heart and kidney disease: a cardiovascular high-risk constellation.
Schunk SJ, Speer T, Fliser D.
Herz. 2021

Repeated exposure to transient obstructive sleep apnea-related conditions causes an atrial fibrillation substrate in a chronic rat model.
Linz B, Hohl M, Lang L, Wong DWL, Nickel AG, De La Torre C, Sticht C, Wirth K, Boor P, Maack C, Speer T, Jespersen T, Schotten U, Sanders P, Böhm M, Linz D.
Heart Rhythm. 2021

WNT-β-catenin signalling - a versatile player in kidney injury and repair.
Schunk SJ, Floege J, Fliser D, Speer T.
Nat Rev Nephrol. 2021

Common APOC3 variants are associated with circulating ApoC-III and VLDL cholesterol but not with total apolipoprotein B and coronary artery disease.
Silbernagel G, Scharnagl H, Kleber ME, Hoffmann MM, Delgado G, Stojakovic T, Gary T, Zeng L, Ritsch A, Zewinger S, Speer T, Schunkert H, Landmesser U, März W, Grammer TB.
Atherosclerosis. 2020

Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice.
Hohl M, Mayr M, Lang L, Nickel AG, Barallobre-Barreiro J, Yin X, Speer T, Selejan SR, Goettsch C, Erb K, Fecher-Trost C, Reil JC, Linz B, Ruf S, Hübschle T, Maack C, Böhm M, Sadowski T, Linz D.
J Biol Chem. 2020

Dickkopf 3-a novel biomarker of the 'kidney injury continuum'.
Schunk SJ, Speer T, Petrakis I, Fliser D.
Nephrol Dial Transplant. 2021

Bleeding complications after cardiac surgery, before anticoagulation start and then with argatroban or heparin in the early postoperative setting.
Klingele M, Enkel J, Speer T, Bomberg H, Baerens L, Schäfers HJ.J 
Cardiothorac Surg. 2020

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation.
Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, Klug M, Schunk SJ, Schmit D, Kramann R, Körbel C, Ampofo E, Laschke MW, Selejan SR, Paschen A, Herter T, Schuster S, Silbernagel G, Sester M, Sester U, Aßmann G, Bals R, Kostner G, Jahnen-Dechent W, Menger MD, Rohrer L, März W, Böhm M, Jankowski J, Kopf M, Latz E, Niemeyer BA, Fliser D, Laufs U, Speer T.
Nat Immunol. 2020